Preparation and performance evaluation of poly (ether-imide) incorporated polysulfone hemodialysis membranes

Senthilkumar, S.; Rajesh, S.; Jayalakshmi, A.; Aishwarya, G. R.; Mohan, D.

doi:10.1007/s10965-012-9867-8

Cited by 19 publications

(9 citation statements)

References 37 publications

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“…Barzin and Sadatnia have shown that delayed demixing results in a spongy structure . The presence of the hydrophilic additives improved the water tolerance of the casting solution and hence the solvent outflux rate decreased significantly on the glass‐contacting (bottom) surface . However, membranes cast on the nonwoven fabric do not show this characteristic (Figure ).…”

Section: Resultsmentioning

confidence: 99%

Investigating the structure and water permeation of membranes modified with natural and synthetic additives using tensile, porosity, and glass transition temperature studies

Vilakati

Hoek

Mamba

2014

J of Applied Polymer Sci

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This article reports the results of a study on the effect of using different additives (lignin, polyethylene glycol [PEG], and polyvinyl pyrrolidone [PVP]) to fabricate ultrafiltration polysulfone (PSf) membranes. The main focus of this study was on the difference in permeation properties brought about by the absence or presence of a fabric when fabricating the membranes. Differential scanning calorimetry was used to characterize the thermal properties and was also used to predict the other membrane properties. An Instron machine was used to evaluate the mechanical properties. The bulk porosity of lignin and PVP‐modified membranes was observed to be higher than that of the membranes modified with PEG. There was a strong negative correlation between the bulk porosity and the glass transition temperature irrespective of the additive used. Membranes cast on a fabric showed higher flux compared with membranes cast on glass. There was a strong positive correlation between the bulk porosity and the observed permeability regardless of whether the membrane was cast on a nonwoven fabric or on a glass plate. Pore‐size distribution results showed that lignin and PVP‐modified membranes had a narrow pore‐size distribution ranging between 10 and 25 nm when compared with PEG‐modified membranes with a pore‐size distribution ranging between 2.5 and 20 nm. These results indicate that thermal, bulk porosity, and mechanical properties can be used to probe the membrane structure. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 40616.

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Section: Resultsmentioning

confidence: 99%

Investigating the structure and water permeation of membranes modified with natural and synthetic additives using tensile, porosity, and glass transition temperature studies

Vilakati

Hoek

Mamba

2014

J of Applied Polymer Sci

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“…Due to modifications where hydrophilic groups are introduced onto the membrane surface, a sharp decline has been observed by other researchers [52][53][54] . Further, it was explained that the protein adsorption on hydrophilic surfaces occurred in one of the two modes.…”

Section: Protein Adsorptionmentioning

confidence: 91%

Graphene Oxide Nanocomposite Incorporated Poly(ether imide) Mixed Matrix Membranes for in Vitro Evaluation of Its Efficacy in Blood Purification Applications

Kaleekkal

Arumugham

Mohan

et al. 2015

Ind. Eng. Chem. Res.

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Hemodialysis is one of the most commonly used treatments for patients suffering from irrecoverable kidney damage. In our present work we investigate polyetherimide (PEI) mixed matrix membranes (MMMs) as a potential candidate for hemodialysis applications due to its efficient clearance and high biocompatibility. Graphene oxide (GO) was synthesized by the modified Hummers' method and was then confirmed by X-ray diffraction spectroscopy, Fourier transform infrared spectroscopy, Raman spectroscopy and high resolution transmission electron microscopy. The GO-polyvinylpyrrolidone nano-composite incorporated PEI MMMs were fabricated by a semi-automatic casting unit, using the non-solvent induced phase separation (NIPS) technique. The effect of the nano-composite loading ratio was evaluated by water content; ultrafiltration rate, and porosity; which were all found to increase as the nano-composite content increased. Cross Sectional and top surface morphology was visualized using scanning electron microscopy and atomic force microscopy. The hydrophilicity of these membranes was in consonance with contact angle values. These MMMs demonstrated an increase in biocompatibility -reduced protein adsorption, suppressed platelet adhesion and lower complement activation. Furthermore the prolonged blood clotting time is an indication of the heparin mimic anticoagulant properties of these membranes. The cytocompatibility results by 3-(4, 5-dimethyl-2-thiazolyl)-2, 5-diphenyl-tetrazolium bromide (MTT) assay and live cell/dead cell staining indicated that there was an increase in cell viability. The membranes with 0.1 wt% GO showed an excellent clearance of the model uremic toxins, namely urea, vitamin B-12 and cytochrome-c in-vitro. The diffusive permeability of these membranes could be comparable to the existing commercial hemodialysis membranes. Thus it can be concluded that these membranes containing a composite of both functional nano-sheets and bioactive polymers have a tremendous potential to be utilized commercially in hemodialysis modules if shown successful in further in-vivo studies with an animal model.

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“…Therefore benchmark PSf flat sheet (home-made) membrane was prepared based on a conventional membrane prepared via phase inversion method [12,14,39,40].…”

Section: Methodsmentioning

confidence: 99%

High performance thin-film nanofibrous composite hemodialysis membranes with efficient middle-molecule uremic toxin removal

Shen

Zhu

et al. 2017

Journal of Membrane Science

122

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Membrane structure design is critical for the development of high-performance hemodialysis membranes. Here, a thin-film nanofibrous composite (TFNC) membrane, consisting of a two-tier composite structure, i.e., an ultrathin hydrophilic separation layer of chemically cross-linked polyvinyl alcohol (PVA), and an electrospun polyacrylonitrile (PAN) nanofibrous supporting layer, was demonstrated as the hemodialysis membrane for the first time. The optimized PVA/PAN TFNC membrane exhibited high permeability (~ 290.5 L/m 2 h at 0.1 MPa) and excellent selectivity which should be attributed to its unique structure with ultrathin separation layer and highly porous supporting layer. In addition, the TFNC membrane also possessed excellent overall mechanical properties, good hydrophilicity and comparable hemocompatibility properties (protein adsorption, platelet adhesion, complement activation, hemolysis ratio). The hemodialysis simulation experiments on optimized TFNC membrane showed that 82.6% of urea and 45.8% of lysozyme were cleaned and 98.8% of bovine serum albumin (BSA) was retained. The TFNC membranes exhibited excellent hemodialysis performances, especially for the middle-molecule uremic toxin removal, which was more efficient than conventional hemodialysis membranes reported so far, suggesting PVA/PAN TFNC membranes as promising alternatives for hemodialysis applications.

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Preparation and performance evaluation of poly (ether-imide) incorporated polysulfone hemodialysis membranes

Cited by 19 publications

References 37 publications

Investigating the structure and water permeation of membranes modified with natural and synthetic additives using tensile, porosity, and glass transition temperature studies

Investigating the structure and water permeation of membranes modified with natural and synthetic additives using tensile, porosity, and glass transition temperature studies

Graphene Oxide Nanocomposite Incorporated Poly(ether imide) Mixed Matrix Membranes for in Vitro Evaluation of Its Efficacy in Blood Purification Applications

High performance thin-film nanofibrous composite hemodialysis membranes with efficient middle-molecule uremic toxin removal

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