Hemodynamic and hemorheologic determinants of left atrial spontaneous echo contrast and thrombus formation in patients with idiopathic dilated cardiomyopathy

Siostrzonek, Peter; Koppensteiner, Renate; Gössinger, Heinz; Zangeneh, M.; Heinz, Gottfried; Kreiner, Gerhard; Stümpflen, Andreas; P, Buxbaum; Ehringer, H; Mösslacher, H

doi:10.1016/0002-8703(93)90022-2

Cited by 55 publications

(39 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The higher frequency of SEC observed in our study compared to previous reports (Vigna et al 1992;Siostrzonek et al 1993;Bilge et al 1999) can be explained by more severe left ventricular systolic dysfunction and larger cardiac chambers of our cases.…”

Section: Effect Of Biventricular Pacing On Left Atrial Seccontrasting

confidence: 67%

“…Left atrial SEC is a frequent finding in patients with left ventricular systolic dysfunction (Siostrzonek et al 1993;Bilge et al 1999). Although it represents a relatively common event, underlying etiology is still not clear.…”

Section: Effect Of Biventricular Pacing On Left Atrial Secmentioning

confidence: 99%

“…In-vitro studies revealed that low blood flow velocity and erythrocyte aggregation play an important role in SEC development (Sigel et al 1981). Siostrzonek et al (1993) showed that, in patients with dilated CMP, left atrial SEC occurs more frequently in those with larger left atrial diameters, lower cardiac output and left atrial flow velocities. In the same study, left ventricular systolic function and atrial fibrillation appeared as the most important determinants atrial flow velocity.…”

Section: Effect Of Biventricular Pacing On Left Atrial Secmentioning

confidence: 99%

“…In patients with dilated cardiomyopathy (CMP) SEC is strongly related to left ventricular ejection fraction, cardiac output, left atrial diameter and left atrial flow velocities and is an indicator for subsequent thromboembolic events (Daniel et al 1988;Castello et al 1990;Siostrzonek et al 1993).…”

mentioning

confidence: 99%

See 3 more Smart Citations

Effect of Cardiac Resynchronization Therapy on Left Atrial Reverse Remodeling and Spontaneous Echo Contrast

Vural

Ağaçdiken

Ural

et al. 2004

Tohoku J. Exp. Med.

View full text Add to dashboard Cite

Recent studies revealed reverse remodeling in left ventricle with cardiac resynchronization therapy (CRT). However, effects on left atrial remodeling, left atrial total emptying fraction and left atrial spontaneous echo contrast (SEC) have not been adequately evaluated. The aim of this study was to investigate the long-term changes in SEC, left atrial reverse remodeling, and left atrial total emptying fraction after CRT. Twenty patients with systolic heart failure and complete left bundle-branch block underwent implantation of biventricular pacemaker devices. Transthoracic and transesophageal echocardiography were performed one week before and one and six months after pacemaker implantation. After biventricular pacemaker implantation, significant clinical improvement was observed in all patients. Left atrial maximal and minimal volumes showed a significant progressive decline after CRT (reverse remodeling). Left atrial total emptying ejection fraction (LATEF) was 33±19% at baseline and increased to 37±10% and 41±11% at the 1st and 6th months respectively (p=0.01 and p=0.04). SEC was detected in 18 of 20 patients (90%) at the beginning of the study. After six months SEC disappeared in 5 patients and frequency of SEC reduced to 45%. Decrease in the intensity of the SEC was also statistically significant (at the 1st and 6th months; p=0.001 and p<0.001 respectively). Long-term CRT results in atrial reverse remodeling, increases LATEF, and reduces both frequency and intensity of atrial SEC. cardiac resynchronization; atrial reverse remodeling; SEC

show abstract

Section: Effect Of Biventricular Pacing On Left Atrial Seccontrasting

confidence: 67%

Section: Effect Of Biventricular Pacing On Left Atrial Secmentioning

confidence: 99%

Section: Effect Of Biventricular Pacing On Left Atrial Secmentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Effect of Cardiac Resynchronization Therapy on Left Atrial Reverse Remodeling and Spontaneous Echo Contrast

Vural

Ağaçdiken

Ural

et al. 2004

Tohoku J. Exp. Med.

View full text Add to dashboard Cite

show abstract

“…At least 11% of patients with dilated CMP have one or more embolic event during the course of this illness, and mural thrombus is more frequently observed in the LV than in the left atrium (1,2).…”

Section: Introductionmentioning

confidence: 99%

The evaluation of mean platelet volume levels in patients with idiopathic and ischemic cardiomyopathy: an observational study

Açıkgöz

Ermiş²,

Yağmur³

et al. 2011

Anadolu Kardiyol Derg

View full text Add to dashboard Cite

ÖZETAmaç: Kardiyomiyopati (KMP) kan stazı, trombosit aktivasyonu ve değişen koagülasyon durumu nedeniyle, artmış tromboemboli ile ilişkili bir hastalıktır. Biz, bu çalışmada iskemik ve idiyopatik KMP'li hastalarda ortalama trombosit hacmini (OTH) belirlemeyi ve onları kontrol grubuyla kıyaslamakla birlikte, KMP'li hastalarda OTH ile ekokardiyografik parametreler arasında bir ilişki olup olmadığını da belirlemeyi amaçladık. Yöntemler: Bu çalışma gözlemsel enine-kesitli çalışma olarak dizayn edildi. Çalışmaya idiyopatik KMP'li 35 hasta, iskemik KMP'li 35 hasta ve kontrol grubu 30 kişi olmak üzere toplam 100 birey dahil edildi. Çalışmaya katılan tüm bireylerin OTH değerleri ölçüldü ve tüm katılanlara transtorasik ekokardiyografi ve anjiyografik değerlendirme yapıldı. İstatistiksel analizler için Ki-kare testi, tek yönlü ANOVA ve Pearson korelasyon testleri kullanıldı. Bulgular: Çalışmamızda OTH değeri idiyopatik ve iskemik KMP'li hastalarda kontrol grubuna göre anlamlı olarak daha yüksek bulundu (9.03±1.3'e karşın 8.77±0.9 ve 7.95±1.0 fl, sırasıyla, p<0.001). Ayrıca OTH değeri idiyopatik KMP'li hastalarda iskemik KMP'li hastalara göre daha yüksekti, ancak bu yükseklik istatistiksel olarak anlamlı değildi (p=0.328). Çalışmamızda OTH değeri ile sol ventrikül diyastol sonu ve sistol sonu çap (r=0.369, p<0.0001; r=0.325, p=0.001, sırasıyla) ve sol atriyal çap (r=0.403, p<0.0001) değerleri arasında pozitif ilişki sol ventrikül ejeksiyon fraksiyonu arasında negatif ilişki bulundu (r=-0.392, p<0.0001). Sonuç: Hem idiyopatik hem iskemik KMP'li hastalarda kontrollerle kıyaslandığında daha yüksek olan OTH değerleri, KMP'li hastaların etiyolojisi ne olursa olsun, trombosit agregasyonuna eğilimini gösterir. Ayrıca, bu hastalarda genişlemiş ve bozulmuş sol ventrikül ile artmış OTH değer-leri arasında bir ilişki olabilir. (Anadolu Kardiyol Derg 2011; 11: 595-9) Anahtar kelimeler: Ortalama trombosit hacmi, tromboz, kardiyomiyopati, ekokardiyografi ABSTRACT Objective: Cardiomyopathy (CMP) is a disorder associated with an increased risk of thromboembolism due to blood stasis, platelet activation and altered coagulation status. In this study, we aimed to investigate mean platelet volume (MPV) in patients with idiopathic CMP and ischemic CMP and to compare with those of the controls, and aimed to determine whether there is a relationship between MVP and echocardiographic parameters in patients with CMP. Methods: This study was designed as an observational cross-sectional study. A total of 100 subjects with idiopathic CMP (n=35), ischemic CMP (n=35) and controls (n=30) were included in the study. The MPV values were measured in all participants. All subjects underwent transthoracic echocardiography and angiographic evaluation. We used Chi-square test, one-way ANOVA and Pearson correlation tests for statistical analysis. Results:The MPV values were significantly higher in patients with idiopathic CMP and ischemic CMP than those of the controls (9.03±1.3 and 8.77±0.9 vs. 7.95±1.0 fl, respectively, p<0.001). The MPV values were although ...

show abstract

Biochemical markers of coagulation activation in mitral stenosis, atrial fibrillation, and cardiomyopathy

Ikeda¹,

Yamamoto²,

Shimada³

1997

Clinical Cardiology

View full text Add to dashboard Cite

Summary: Advances in the understanding of the biochemistry of the mechanism ofhemostasis have led to the development of sensitive methods for determining levels of markers which reflect thrombin activity (thrombin-antithrombin I11 complex, fibrinopeptide A, FI +2 fragment), active fibrinolysis (D-dimer, plasmin-a2-plasmin inhibitor complex), and platelet activity (platelet factor 4, P-thromboglobulin) in vivo. Measurement of these markers may be useful in identifying patients with various cardiovascular disorders at high risk of thromboenibolism.

show abstract

Hemodynamic and hemorheologic determinants of left atrial spontaneous echo contrast and thrombus formation in patients with idiopathic dilated cardiomyopathy

Cited by 55 publications

References 24 publications

Effect of Cardiac Resynchronization Therapy on Left Atrial Reverse Remodeling and Spontaneous Echo Contrast

Effect of Cardiac Resynchronization Therapy on Left Atrial Reverse Remodeling and Spontaneous Echo Contrast

The evaluation of mean platelet volume levels in patients with idiopathic and ischemic cardiomyopathy: an observational study

Biochemical markers of coagulation activation in mitral stenosis, atrial fibrillation, and cardiomyopathy

Contact Info

Product

Resources

About