The evaluation of mean platelet volume levels in patients with idiopathic and ischemic cardiomyopathy: an observational study

Açıkgöz, Nusret; Ermiş, Necip; Yağmur, Jülide; Cansel, Mehmet; Atas, Halil; Pekdemir, Haşan; Оздемир, Рамазан

doi:10.5152/akd.2011.161

Cited by 10 publications

(9 citation statements)

References 36 publications

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“…MPV may be increased in other cardiovascular conditions such as pulmonary arterial hypertension [16], hypertrophic cardiomyopathy [17], and decompensated heart failure [18, 19], which may explain the increase in thromboembolic events in these conditions [20], Until now, only a few studies with small sample sizes have examined the relationship between MPV and left ventricular systolic and diastolic dysfunction, and left ventricular hypertrophy [21–23]. To this end, in the current study, we analyzed the relationship between platelet indices (MPV, PDW) and left ventricular systolic and diastolic cardiac dysfunction and hypertrophy among patients admitted to the Cardiology Department.…”

Section: Introductionmentioning

confidence: 99%

Platelet volume indices are associated with systolic and diastolic cardiac dysfunction, and left ventricular hypertrophy

Fujita

Takeda

Kizawa

et al. 2015

BMC Cardiovasc Disord

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BackgroundMean platelet volume (MPV) and platelet distribution width (PDW) are indices that reflect platelet activity. We investigated the association between these platelet indices and left ventricular hypertrophy and cardiac function.MethodsWe analyzed the data of 1241 patients who were admitted to the Cardiology Department.ResultsBoth MPV and PDW were selected as independent factors associated with left ventricular systolic and diastolic dysfunction, and left ventricular hypertrophy. The highest tertile of MPV and PDW was associated with left ventricular systolic dysfunction (left ventricular ejection fraction of <50 %) with an odds ratio of 1.53 and 2.03, respectively, when the respective lowest tertile was used as reference. The highest PDW tertile was associated with left ventricular hypertrophy with an odds ratio of 1.56 (95 % CI, 1.13–2.15) and with dysfunction with an odds ratio of 3.34 (95 % CI, 1.54–7.25).ConclusionsIndices of platelet activation (MPV and/or PDW) were independently associated positively with left ventricular hypertrophy and left ventricular systolic and diastolic dysfunction. Whether these platelet indices represent useful markers for identifying individuals at higher risk for thromboembolic disease and organ damage among cardiac patients awaits further investigation.

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Section: Introductionmentioning

confidence: 99%

Platelet volume indices are associated with systolic and diastolic cardiac dysfunction, and left ventricular hypertrophy

Fujita

Takeda

Kizawa

et al. 2015

BMC Cardiovasc Disord

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“…Açikgöz et al found a positive correlation between MPV and LA diameter in patients with heart failure. 5 Ozkan et al also showed that MPV and LA diameter were independent predictors of ischemic stroke in patients with sinus rhythm. 6 Finally, based on the current results, the relationship between HCM and MPV has not been totally clarified.…”

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confidence: 99%

Relationship Between Mean Platelet Volume and Hypertrophic Cardiomyopathy

2014

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“…Thus, more severely affected myocardium may be the result of the more persistent, extensive, and severe platelet activation. MPV was significantly higher in both ischaemic and non-ICM patients, compared with healthy controls in another study; this study demonstrated not only the correlation between high MPV levels and a decreased ejection fraction, but also the relationship between the high thromboembolic risk in cardiomyopathies and high MPV levels [21]. Since MPV is affected by several factors, such as increased levels of interleukins in cardiomyopathies, there may be a non-causal relationship between MPV and these factors.…”

Section: Discussionmentioning

confidence: 87%

Association of mean platelet volume with presence of non-viable myocardium in ischaemic cardiomyopathy

Öztürk

Gurbuz

Efe³

et al. 2017

Kardiol Pol

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A b s t r a c tBackground: Parameters derived from complete blood count, such as mean platelet volume (MPV), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR), have recently been proposed as measures of inflammation in addition to C-reactive protein (CRP), a classical inflammatory marker. Significant association of these parameters with atherosclerosis and complications have increasingly been reported. Aim:The aim of the study is to evaluate the relationship between these parameters and the presence of myocardial viability assessed with positron emission tomography (PET) in patients with ischaemic cardiomyopathy (ICM).Methods: A total of 122 ICM patients who had undergone PET were enrolled in this study. The patients were dichotomised depending on the presence of transmural scar. Group 1 consisted of 21 patients who had transmural scar tissue only, who were accepted as the group having non-viable myocardium. Group 2 consisted of 101 patients who had hibernation and/or non-transmural scar, who were accepted as the group having viable myocardium. Haematological parameters within 30 days of PET imaging were retrospectively analysed.Results: There were no significant differences between the two groups regarding values of white blood cell, neutrophil, lymphocyte, platelet, haemoglobin, red cell distribution width, CRP, PLR, and NLR. Patients with non-viable myocardium have significantly higher levels of MPV (p = 0.002). In multiple logistic regression analysis, MPV (odds ratio [OR] = 0.373, 95% confidence interval [CI] 0.20-0.69, p = 0.002), was identified as an independent predictor of non-viable myocardium. In receiver-operator characteristic (ROC) analysis, a cut-point of 8.19 identified patients with non-viable myocardium (area under curve: 0.72, 95% CI 0.60-0.84). An MPV value greater than 8.19 demonstrated a sensitivity of 76% and a specificity of 55%. Conclusions:The present study showed that MPV is an inexpensive, clinical, and routinely measurable parameter that is associated with the presence of viable myocardium in ICM.

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The evaluation of mean platelet volume levels in patients with idiopathic and ischemic cardiomyopathy: an observational study

Cited by 10 publications

References 36 publications

Platelet volume indices are associated with systolic and diastolic cardiac dysfunction, and left ventricular hypertrophy

Platelet volume indices are associated with systolic and diastolic cardiac dysfunction, and left ventricular hypertrophy

Relationship Between Mean Platelet Volume and Hypertrophic Cardiomyopathy

Association of mean platelet volume with presence of non-viable myocardium in ischaemic cardiomyopathy

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