Hemodynamic effects of endurance training on canine left ventricle

Rämö, P.; Kettunen, Raimo; Hirvonen, L

doi:10.1152/ajpheart.1987.252.1.h7

Cited by 4 publications

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“…The heart rates were relatively low after each exercise during the 40 kmlday training period (1 15-130 per minute) and decreased to 60-90 per minute within 10 min after the exercise. In an earlier report, beagle dogs that underwent a submaximal test of running on a treadmill with a 15" uphill inclination of similar speed for 6-7 weeks had a mean heart rate of 170 per minute (37). In an untrained state, the heart rates rose up to 200 beats per minute (37).…”

Section: Discussionmentioning

confidence: 90%

Long‐distance running alters bone anthropometry, elemental composition and mineral density of young dogs

Puustjärvi

Lappalainen

Niemitukia

et al. 1995

Scandinavian Med Sci Sports

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Long-distance running alters bone anthropometry, elemental composition and mineral density of young dogs Puustjarvi K, Lappalainen R, Niemitukia L, Arnala I, Nieminen J, Tammi M, Helminen HJ. Long-distance running alters bone anthropometry, elemental composition and mineral density of young dogs. Scand J Med Sci Sports 1995: 5: 17-23. 0 Munksgaard, 1995 Ten young beagle dogs were run on a treadmill for 1 year, the last 15 weeks 40 kdday. Thereafter bone anthropometric variables, elemental composition, mineral density (BMD) and serum markers of bone metabolism were analyzed and compared with matched-paired control dogs. More osteophytes developed, weight-bearing bones grew larger and BMD of axial skeleton was reduced in the trained group. Zinc and sodium accumulated in bones of the runners. Zinc correlated negatively with BMD. Serum osteocalcin and C-terminal propeptide of type I procollagen did not correlate with the observed differences in BMD. This experiment implies that intensive endurance training in adolescence may reduce the peak bone I mass and alter the structural properties of bone.Bone growth during childhood and adolescence and development of peak bone mass depend on both internal (that is, genetic) and external (such as nu-

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Section: Discussionmentioning

confidence: 90%

Long‐distance running alters bone anthropometry, elemental composition and mineral density of young dogs

Puustjärvi

Lappalainen

Niemitukia

et al. 1995

Scandinavian Med Sci Sports

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Anabolic steroids alter the haemodynamic effects of endurance training on the canine left ventricle

et al. 1987

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The effects of six week, high-dose anabolic steroid treatment (methandienone, 1.5 mg/kg/day) on the changes in left ventricular function induced in dogs by endurance training were studied by a catheterization technique under anaesthesia. Pacing, isoproterenol and dextran infusions were used as loading tests (respectively). Dogs were randomized into an exercise group (EG, n = 7) and an exercise-steroid group (ESG, n = 7), the latter receiving anabolic steroids as well as participating in the training program. In a standardized submaximal exercise test, the heart rate of unanesthetized dogs was lower both in the EG (p less than 0.001) and in the ESG (p less than 0.01) after the training period than before it. In the EG the resting systemic vascular resistance (SVR) before haemodynamic interventions was lower (p less than 0.05) and left ventricular stroke work (SW) was higher (p less than 0.05) after the training period than before. In the ESG, left ventricular ejection fraction (EF) decreased with training and anabolic steroid treatment (p less than 0.05). After the training period isoproterenol increased the maximum velocity of the cardiac contractile element significantly more (p less than 0.05) in the EG than in the ESG. Also SW increased in the EG (29%, p less than 0.001), but not in the ESG (-11%, NS). Endurance training increased the left ventricular end-diastolic and stroke volumes during isoproterenol infusion, but this training effect was attenuated by simultaneous anabolic steroid treatment (p less than 0.05 between the groups in both cases). During the isoproterenol test SVR decreased less in ESG than in EG (p less than 0.05 between).(ABSTRACT TRUNCATED AT 250 WORDS)

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Effects of training and anabolic steroids on collagen synthesis in dog heart

Takala

Rämö

Kiviluoma

et al. 1991

Europ. J. Appl. Physiol.

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The effects of endurance training and anabolic steroid (Methandienone 1.5 mg.kg-1 p. o. daily) and their combination on regional collagen biosynthesis and concentration in the hearts of male beagle dogs were studied by measuring prolyl 4-hydroxylase (PH) activity and hydroxyproline (HYP) concentration. The PH (P less than 0.05) and HYP (P less than 0.05) were both greater in the subendocardinal layer than in the subepicardium (EPI) of the left ventricular wall in controls, whereas opposite gradients (P less than 0.05) were observed in the right ventricle. Endurance exercise caused an increase of PH activity in EPI of the left ventricular wall (P less than 0.01). The HYP concentration increased in both layers of the right ventricle in the exercise plus steroid group (P less than 0.05). The results suggest that transmural differences exist in the rate of collagen synthesis and concentration in canine cardiac ventricles and that endurance exercise may accelerate collagen synthesis in EPI of the left ventricle and the combination of exercise and anabolic steroid causes an increase in collagen concentration in the right ventricular wall.

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Hemodynamic effects of endurance training on canine left ventricle

Cited by 4 publications

References 0 publications

Long‐distance running alters bone anthropometry, elemental composition and mineral density of young dogs

Long‐distance running alters bone anthropometry, elemental composition and mineral density of young dogs

Anabolic steroids alter the haemodynamic effects of endurance training on the canine left ventricle

Effects of training and anabolic steroids on collagen synthesis in dog heart

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