Hemodynamic Effects of Levosimendan Compared With Dobutamine in Patients With Low Cardiac Output After Cardiac Surgery

Part 14: Pediatric Advanced Life Support

“…In animal studies after resuscitation from cardiac arrest 418,419,[421][422][423][424] and post-cardiac surgical experience in children 352 and adults, [425][426][427][428] hemodynamic improvement was associated with administration of selected vasoactive agents. Each drug and dose must be tailored to the patient because clinical response is variable.…”

Levosimendan for the treatment of acute severe heart failure: A meta-analysis of randomised controlled trials

“…1 shows the flow of studies and the reasons for exclusion. Of the trials included, 16 [12][13][14]17,18,[31][32][33][34][35][36][37][38][39][40][41] Table 2 Summary of the validity assessments of randomised clinical trials of levosimendan in patients with acute severe heart failure.…”

“…Intention to treat analysis Blinding Follath [37] No Yes No Nieminen [40] No Yes No RUSSLAN [17] Yes No Yes Follath [18] Yes Yes Yes REVIVE I [44] No No Yes Parrisis [13] No Yes No CASINO [43] No No Yes DeLuca [36] No Yes No Moertl [38] No No No Parrisis [14] No Yes No Avgeropolou [34] No Yes No Morelli [39] No No Yes Adamopolous [12] No Yes No Tziakis [41] No Yes No REVIVE II [42] No No Yes Al-Shawaf [32] Yes Yes No Alvarez [33] No No No SURVIVE [31] Yes Yes Yes DeHert [35] Yes Yes No Fig. 2.…”

Lebensrettende Maßnahmen bei Kindern („paediatric life support“)

“…Volumentherapie und vasoaktive Substanzen (Adrenalin, Dobutamin, Dopamin und Noradrenalin) können die hämody-namischen Parameter bei Kindern nach einem Kreislaufstillstand verbessern und sollen so titriert werden, dass der systolische Blutdruck zumindest über dem 5. Altersperzentil liegt [29, [379][380][381][382][383][384][385][386][387][388][389][390].…”