Hemodynamic Function of Forearm Muscle in Postmenopausal Women With Type 2 Diabetes

Pollonini, Luca; Cox, Lauren Gulley; Gorniak, Stacey L.

doi:10.1123/japa.2019-0221

Cited by 4 publications

(7 citation statements)

References 38 publications

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“…Tactile sensitivity loss due to peripheral neuropathy (PN) has been implicated as the primary cause of both sensory and motor deficits in the hands and feet of PwDM [7][8][9][10]; however, our recent work has demonstrated that motor changes in PwDM occur independent of such tactile impairment, and appear to be unrelated to disease duration and severity [2][3][4][5]11]. Our data indicate other physiological factors such as vascular dysfunction and functional cortical changes as the underlying mechanism for sensorimotor changes in PwDM [2][3][4][5][11][12][13][14]. Due to the confluence of multiple systemic changes in the bodies of PwDM, the contribution of multiple systems−including sex hormone changes and impaired global hemodynamic function−to sensorimotor dysfunction prior to PN diagnosis in PwDM is fully plausible.…”

Section: Introductionmentioning

confidence: 65%

“…Recently, our group found no differences in tactile function of postmenopausal female PwDM as compared to age-and sex-matched controls during the assessment of upper extremity muscle hemodynamics [13]. This finding was intriguing as abnormal hemodynamic function of upper extremity muscle was found in PwDM and supports vascular dysfunction as a potential source of global sensorimotor changes in PwDM [10,15], particularly in females as females have a higher overall risk of cardiovascular complications with age; however, the lack of between group tactile function differences challenged this point of view.…”

Section: Introductionmentioning

confidence: 73%

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Sex-based differences and aging in tactile function loss in persons with type 2 diabetes

et al. 2020

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Background Recent evidence of significant sex-based differences in the presentation of Type 2 Diabetes Mellitus (DM) and its complications has been found in humans, which may contribute to sex-based differences in reduced functionality and quality of life. Some functionality, such as tactile function of the hands, has significant direct impact on quality of life. The purpose of the current study was to explore the impact of DM and sex on tactile function, with consideration of variability in health state measures. Research design and methods A case-control single time point observational study from 2012–2020 in an ethnically diverse population-based community setting. The sample consists of 132 adult individuals: 70 independent community dwelling persons with DM (PwDM) and 62 age- and sex-matched controls (42 males and 90 females in total). The Semmes-Weinstein monofilament test was used to evaluate tactile sensation of the hands. Results Tactile sensation thresholds were adversely impacted by sex, age, degree of handedness, high A1c, diagnosis of DM, and neuropathy. Overall, strongly right-handed older adult males with poorly controlled DM and neuropathy possessed the poorest tactile discrimination thresholds. When self-identified minority status was included in a secondary analysis, DM diagnosis was no longer significant; negative impacts of age, neuropathy, degree of handedness, and high A1c remained significant. Conclusions The data indicate significant impacts of male sex, age, degree of handedness, self-identified minority status, and metabolic health on the development of poor tactile sensation. This combination of modifiable and non-modifiable factors are important considerations in the monitoring and treatment of DM complications.

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Section: Introductionmentioning

confidence: 65%

Section: Introductionmentioning

confidence: 73%

Sex-based differences and aging in tactile function loss in persons with type 2 diabetes

et al. 2020

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“…40 However, DM is also associated with impaired hyperemic responses, endothelial dysfunction, and microvascular dysfunction. 13,16,41,42 DM has also recently been linked to pathological neurovascular decoupling in PwDM (as reviewed in Ref. 43) and conflicting reports of reduced cerebral blood flow.…”

Section: Functional Cortical Activity and Tissue Oxygenationmentioning

confidence: 99%

“…12 Our data point toward other factors, such as alterations in motor unit structure-function and reduced hemodynamic function of muscle and the cortex as underlying mechanisms for these sensorimotor changes. 13 Due to the confluence of multiple systemic changes in the body in PwDM, the contribution of impaired or altered cortical function to sensorimotor dysfunction prior to PN diagnosis in PwDM is fully plausible.…”

Section: Introductionmentioning

confidence: 99%

“…14 Specifically, endothelial dysfunction within dermal and muscle tissues in adult PwDM has been related to altered motor behaviors, including abnormal force production. 13,15,16 Currently, it is unclear whether hemodynamic function of cortical tissues, as evidenced by abnormal cortical activation patterns, also occurs in PwDM. Correspondingly, our hypothesis is that altered hemodynamic function of the cortex occurs during tactile sensory and manual motor tasks.…”

Section: Introductionmentioning

confidence: 99%

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Functional neuroimaging of sensorimotor cortices in postmenopausal women with type II diabetes

et al. 2020

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Significance: Deficits in sensorimotor function in persons with type II diabetes mellitus (PwDM) have traditionally been considered a result of peripheral nerve damage. Emerging evidence has suggested that factors outside of nerve damage due to type II diabetes mellitus, such as impaired hemodynamic function, contribute significantly to both sensory and motor deficits in PwDM. Aim: The focus of the current study was to evaluate functional cortical hemodynamic activity during sensory and motor tasks in PwDM. Approach: Functional near-infrared spectroscopy was used to monitor oxyhemoglobin (HbO) and deoxyhemoglobin (HbR) across the cortex during sensory and motor tasks involving the hands. Results: Decline in HbO across sensory and motor regions of interest was found in PwDM with simultaneous deficits in manual motor tasks, providing the first evidence of functional cortical hemodynamic activity deficits relating to motor dysfunction in PwDM. Similar deficits were neither specifically noted in HbR nor during evaluation of sensory function. Health state indices, such as A 1c , blood pressure, body mass index, and cholesterol, were found to clarify group effects. Conclusions: Further work is needed to clarify potential sex-based differences in PwDM during motor tasks as well as the root of reduced cortical HbO indices but unchanged HbR indices in PwDM.

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Functional near infrared spectroscopy detects cortical activation changes concurrent with memory loss in postmenopausal women with Type II Diabetes

et al. 2023

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Older adults with Type II Diabetes Mellitus (DM) experience mild cognitive impairment, specifically in the domain of recall/ working memory. No consistent causative structural cortical deficits have been identified in persons with DM (PwDM). Memory deficits may be exacerbated in older adult females, who are at the highest risk of cardiovascular decline due to DM. The focus of the current study was to evaluate functional cortical hemodynamic activity during memory tasks in postmenopausal PwDM. Functional Near Infrared Spectroscopy (fNIRS) was used to monitor oxyhemoglobin (HbO) and deoxyhemoglobin (HbR) during memory-based tasks in a cross-sectional sample of postmenopausal women with DM. Twenty-one community-dwelling DM females (age = 65 ± 6 years) and twenty-one age-and sex-matched healthy controls (age = 66 ± 6 years) were evaluated. Working memory performance (via N-back) was evaluated while study participants donned cortical fNIRS. Health state, metabolic data, and menopausal status data were also collected. Deficits in working memory accuracy were found in the DM group as compared to controls. Differences in HbO responses emerged in the DM group. The DM group exhibited altered PFC activity magnitudes and increased functional cortical activity across ROIs compared to controls. HbO and HbR responses were not associated with worsened health state measures. These data indicate a shift in cortical activity patterns with memory deficits in postmenopausal PwDM. This DM-specific shift of HbO is a novel finding that is unlikely to be detected by fMRI. This underscores the value of using non-MRI-based neuroimaging techniques to evaluate cortical hemodynamic function to detect early mild cognitive impairment.

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Hemodynamic Function of Forearm Muscle in Postmenopausal Women With Type 2 Diabetes

Cited by 4 publications

References 38 publications

Sex-based differences and aging in tactile function loss in persons with type 2 diabetes

Sex-based differences and aging in tactile function loss in persons with type 2 diabetes

Functional neuroimaging of sensorimotor cortices in postmenopausal women with type II diabetes

Functional near infrared spectroscopy detects cortical activation changes concurrent with memory loss in postmenopausal women with Type II Diabetes

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