Hemodynamic Impact of Intrathecal versus Epidural Analgesia with Sufentanil in the Early Phase of Labor: A Randomized Controlled Trial

Abstract

Background: Combined spinal epidural analgesia (CSEA) has become a widespread technique in obstetric analgesia. Sufentanil is currently widely used in combination with a low concentration of local anaesthetic to reduce both motor block and local anesthetic requirements. While some studies have reported on the hemodinamic changes after the intrathecal administration of sufentanil in the early phase of labor, no randomized controlled trials have been performed. We compared hemodynamic impact, quality of the analgesia, safety, side effects and impact on labor and delivery after the administration of two equipotent doses of sufentanil given by intrathecal versus epidural route.

Effect of Epidural Bupivacaine Versus Intrathecal Single Dose inAnalgesia during Normal Vaginal Labor of Multiparous Women

“…In agreement with the present study Rabiei et al [10] conducted their study to compare the effects of epidural and spinal on the analgesia and blood gases in neonates born during vaginal delivery and revealed that the hemodynamic status of the mothers before and during the first postoperative period was in the normal range. In the same line of our study Meneghetti et al [11] who compared hemodynamic impact of intrathecal versus epidural analgesia with sufentanilin parturient in first stage of labor. Also, cochrane review [12] that compared CSEA (Combined spinal epidural analgesia) and EA (epidural analgesia) involving 3274 women found no difference in maternal hypotension whereas a more rapid onset of analgesia in the CSEA.…”