Hemoglobin-derived peptides and mood regulation

Wei, Fengmei; Zhao, Long; Jing, Yu‐Hong

doi:10.1016/j.peptides.2020.170268

Cited by 16 publications

(11 citation statements)

References 152 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We are aware of the fact that there are other review articles concerning hemorphins published during the last five years, but they were concerning highly specialized aspects of knowledge. This involves very good reviews published in 2016: hemorphins in cancer biology [19], hemorphins in multiple sclerosis, metabolic and immune aspects [20]; in 2018: the role of hemorphins in moods modulation and emotions [21], therapeutic effects of hemorphins in human and animal models [18]; and the latest review published in 2021 that focuses on pharmacological and functional targeting of G protein-coupled receptors (GPCRs) by hemorphins and their implication in physiology and pathophysiology [22].…”

Section: Introductionmentioning

confidence: 99%

Hemorphins—From Discovery to Functions and Pharmacology

et al. 2021

View full text Add to dashboard Cite

During the last three decades, a variety of different studies on bioactive peptides that are opioid receptor ligands, have been carried out, with regard to their isolation and identification, as well as their molecular functions in living organisms. Thus, in this review, we would like to summarize the present state-of-the art concerning hemorphins, methodological aspects of their identification, and their potential role as therapeutic agents. We have collected and discussed articles describing hemorphins, from their discovery up until now, thus presenting a very wide spectrum of their characteristic and applications. One of the major assets of the present paper is a combination of analytical and pharmacological aspects of peptides described by a team who participated in the initial research on hemorphins. This review is, in part, focused on the analysis of endogenous opioid peptides in biological samples using advanced techniques, description of the identification of synthetic/endogenous hemorphins, their involvement in pharmacology, learning, pain and other function. Finally, the part regarding hemorphin analogues and their synthesis, has been added.

show abstract

Section: Introductionmentioning

confidence: 99%

Hemorphins—From Discovery to Functions and Pharmacology

et al. 2021

View full text Add to dashboard Cite

show abstract

“…To further underline the importance of the circulation of fluids and to corroborate the model of the five diaphragms, is the relationship between blood and the psychological aspect. Red blood cells or erythrocytes can be considered as endocrine glands capable of secreting many substances [12]. Among the substances produced in paracrine mode, there are some molecules that result from the degradation of haemoglobin, through enzymes such as proteasomes and oligopeptidases.…”

Section: Introductionmentioning

confidence: 99%

“…Among the substances produced in paracrine mode, there are some molecules that result from the degradation of haemoglobin, through enzymes such as proteasomes and oligopeptidases. From this degradation, we find hemopressin (Hp) and hemophin, which attach to cannabinoid receptors (CBr1 and CBr2) [12]. A portion of hemopressin, in particular, Hb-alpha1 can be considered a neuropeptide, capable of having anti-nociceptive effects (reduces the sensations of hyperalgesia and visceral pain), is capable of improving memory and ability to regulate the mood [13].…”

Section: Introductionmentioning

confidence: 99%

“…A portion of hemopressin, in particular, Hb-alpha1 can be considered a neuropeptide, capable of having anti-nociceptive effects (reduces the sensations of hyperalgesia and visceral pain), is capable of improving memory and ability to regulate the mood [13]. Hp stimulates the release of endorphins, exerting anxiolytic and antidepressant effects as allosteric agents, targeting CBr1 and CBr2 centrally [12,13]. Hemophin would act to promote a correct anti-inflammatory and anti-nociceptive response, always through the endocannabinoid pathway [12,13].…”

Section: Introductionmentioning

confidence: 99%

“…Hp stimulates the release of endorphins, exerting anxiolytic and antidepressant effects as allosteric agents, targeting CBr1 and CBr2 centrally [ 12 , 13 ]. Hemophin would act to promote a correct anti-inflammatory and anti-nociceptive response, always through the endocannabinoid pathway [ 12 , 13 ]. Body diaphragms must be considered as three-dimensional structures, represented on multiple planes and axes; it is a mistake to consider a body structure extrapolated from its three-dimensionality.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The Five Diaphragms in Osteopathic Manipulative Medicine: Neurological Relationships, Part 1

Bordoni¹

2020

Cureus

View full text Add to dashboard Cite

In osteopathic manual medicine (OMM), there are several approaches for patient assessment and treatment. One of these is the five diaphragm model (tentorium cerebelli, tongue, thoracic outlet, diaphragm, and pelvic floor), whose foundations are part of another historical model: respiratory-circulatory. The myofascial continuity, anterior and posterior, supports the notion the human body cannot be divided into segments but is a continuum of matter, fluids, and emotions. In this first part, the neurological relationships of the tentorium cerebelli and the lingual muscle complex will be highlighted, underlining the complex interactions and anastomoses, through the most current scientific data and an accurate review of the topic. In the second part, I will describe the neurological relationships of the thoracic outlet, the respiratory diaphragm and the pelvic floor, with clinical reflections. In literature, to my knowledge, it is the first time that the different neurological relationships of these anatomical segments have been discussed, highlighting the constant neurological continuity of the five diaphragms.

show abstract

An update on animal models of intervertebral disc degeneration and low back pain: Exploring the potential of artificial intelligence to improve research analysis and development of prospective therapeutics

et al. 2023

View full text Add to dashboard Cite

Animal models have been invaluable in the identification of molecular events occurring in and contributing to intervertebral disc (IVD) degeneration and important therapeutic targets have been identified. Some outstanding animal models (murine, ovine, chondrodystrophoid canine) have been identified with their own strengths and weaknesses. The llama/alpaca, horse and kangaroo have emerged as new large species for IVD studies, and only time will tell if they will surpass the utility of existing models. The complexity of IVD degeneration poses difficulties in the selection of the most appropriate molecular target of many potential candidates, to focus on in the formulation of strategies to effect disc repair and regeneration. It may well be that many therapeutic objectives should be targeted simultaneously to effect a favorable outcome in human IVD degeneration. Use of animal models in isolation will not allow resolution of this complex issue and a paradigm shift and adoption of new methodologies is required to provide the next step forward in the determination of an effective repairative strategy for the IVD. AI has improved the accuracy and assessment of spinal imaging supporting clinical diagnostics and research efforts to better understand IVD degeneration and its treatment. Implementation of AI in the evaluation of histology data has improved the usefulness of a popular murine IVD model and could also be used in an ovine histopathological grading scheme that has been used to quantify degenerative IVD changes and stem cell mediated regeneration. These models are also attractive candidates for the evaluation of novel anti‐oxidant compounds that counter inflammatory conditions in degenerate IVDs and promote IVD regeneration. Some of these compounds also have pain‐relieving properties. AI has facilitated development of facial recognition pain assessment in animal IVD models offering the possibility of correlating the potential pain alleviating properties of some of these compounds with IVD regeneration.

show abstract

Hemoglobin-derived peptides and mood regulation

Cited by 16 publications

References 152 publications

Hemorphins—From Discovery to Functions and Pharmacology

Hemorphins—From Discovery to Functions and Pharmacology

The Five Diaphragms in Osteopathic Manipulative Medicine: Neurological Relationships, Part 1

An update on animal models of intervertebral disc degeneration and low back pain: Exploring the potential of artificial intelligence to improve research analysis and development of prospective therapeutics

Contact Info

Product

Resources

About