Hemoglobin glycation index is associated with incident chronic kidney disease in subjects with impaired glucose metabolism: A 10-year longitudinal cohort study

Kim, Won-Jin; Go, Tae-Hwa; Kang, Dae Ryong; Lee, Mi Kyung; Huh, Ji Hye

doi:10.1016/j.jdiacomp.2020.107760

Cited by 15 publications

(9 citation statements)

References 36 publications

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“… 11 , 12 HbA1c can be affected by many factors, such as age, red blood cell lifespan, anemia, genetic factors, etc. 13 Therefore, the hemoglobin glycosylation index (HGI) is introduced to quantify the individual differences between fasting blood glucose (FBG) and HbA1c. 14 Researches found that high HGI levels are associated with many chronic complications of diabetes, including diabetic retinopathy and diabetic nephropathy, especially cardiovascular disease.…”

Section: Introductionmentioning

confidence: 99%

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Correlation Between Hemoglobin Glycosylation Index and Nerve Conduction Velocity in Patients with Type 2 Diabetes Mellitus

Li¹,

Gao²,

Jia³

et al. 2021

DMSO

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Objective This study aimed to investigate the relationship between hemoglobin glycation variation index (HGI) and peripheral nerve conduction velocity (NCV) in patients with type 2 diabetes mellitus (T2DM). Materials and Methods This is a cross-sectional study, including 324 patients with T2DM were included in this study. Basic information and blood indicators were collected. The motor conduction velocities (MCV) of the bilateral ulnar nerve, median nerve, and common peroneal nerve, and the sensory conduction velocities (SCV) of the ulnar nerve, median nerve, and superficial peroneal nerve were measured. The patients were divided into two groups according to the NCV: normal nerve conduction group (NCVN group) and abnormal nerve conduction group (NCVA group). When the NCV is less than the specific normal value, the patients were divided into the NCVA group. HGI was calculated as the difference between the measured and predicted values of glycosylated hemoglobin (HbA1c) using the linear relationship between HbA1c level and fasting plasma glucose levels. At last, all study participants were divided into High HGI and Low HGI groups using the median of HGI as the boundary. The study also analyzed the correlation between HGI and NCV. Results Compared to the NCVN group, the HGI levels of the NCVA group were higher ( P < 0.001). The prevalence of NCVA in the high HGI group was higher than that in the low HGI group ( P = 0.004). HGI was negatively correlated with bilateral ulnar nerve MCV, bilateral median nerve MCV, bilateral common peroneal nerve MCV, bilateral median nerve SCV and left superficial peroneal nerve SCV, and the correlation still existed after adjusting for confounding factors. Conclusion This study found that HGI is inversely associated with NCV in patients with T2DM, and this correlation is higher between HGI and MCV of peripheral nerve.

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Section: Introductionmentioning

confidence: 99%

“… 14 Researches found that high HGI levels are associated with many chronic complications of diabetes, including diabetic retinopathy and diabetic nephropathy, especially cardiovascular disease. 13–16 …”

Section: Introductionmentioning

confidence: 99%

Correlation Between Hemoglobin Glycosylation Index and Nerve Conduction Velocity in Patients with Type 2 Diabetes Mellitus

Li¹,

Gao²,

Jia³

et al. 2021

DMSO

View full text Add to dashboard Cite

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“…Researches suggested that high HGI is associated with an increased risk of many chronic complications of diabetes, including diabetic retinopathy and diabetic nephropathy, especially cardiovascular disease. [9][10][11] However, there are currently no data about the relationship between HGI and vitamin D among patients with T2DM. Considering the importance of vitamin D in the body, the purpose of this study was to investigate: 1) The relationship between HGI and vitamin D in patients with T2DM, and whether there is any difference between males and females; 2) Whether HGI is an independent factor for vitamin D levels.…”

Section: Introductionmentioning

confidence: 99%

“…12 High HGI has been reported to be associated with increased risks of cardiovascular disease, diabetic retinopathy and nephropathy in diabetic individuals. 8,9,11 And in non-diabetic individuals, subjects with high HGI have a higher prevalence of non-alcoholic fatty liver disease, carotid atherosclerosis. 30,31 This study found a higher prevalence of vitamin D deficiency in patients with high HGI, and the HGI levels were inversely correlated with vitamin D.…”

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confidence: 99%

The Relationship Between Hemoglobin Glycation Variation Index and Vitamin D in Type 2 Diabetes Mellitus

Li¹,

Wang²,

Jia³

et al. 2021

DMSO

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Objective This study aimed to investigate the relationship between hemoglobin glycation variation index (HGI) and vitamin D in patients with type 2 diabetes mellitus (T2DM). Materials and Methods This is a cross-sectional study that recruited 347 patients with T2DM. The subjects were divided into no vitamin D deficiency group (25(OH)D ≥20 ng/mL) and vitamin D deficiency group (25(OH)D < 20 ng/mL). HGI was calculated as the difference between the measured and predicted values of HbA1c using the linear relationship between HbA1c level and fasting plasma glucose levels. All study participants were divided into high HGI and low HGI groups using the median of HGI as the boundary. At last, the subjects were divided into male group and female group, and these groups were further subdivided into vitamin D deficiency group and no vitamin D deficiency group. Results The levels of HGI were significantly higher in the vitamin D deficiency group compared with the no vitamin D deficiency group for all patients. The same was true for female patients but not for male patients. The prevalence of vitamin D deficiency in the high HGI group was higher than that in the low HGI group. The high HGI group had lower vitamin D levels compared to the low HGI group. Compared to the male group, the female group had lower vitamin D levels but higher HGI levels. A negative correlation existed between 25(OH) D and HGI in all subjects, as well as in the female-only subgroups. In the male-only subgroups, there was no correlation between them, and this positive correlation still existed after adjusting for other factors in multilinear regression analysis. Conclusion Our study showed for the first time that HGI is inversely associated with vitamin D in all patients with T2DM, and the correlation was also found in female patients, but not in male patients.

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“…The hemoglobin glycation index (HGI; laboratory A1c – predicted A1c) is a marker to quantify inter‐individual variation in glycosylation of hemoglobin 2 . In type 2 diabetes, a high HGI is associated with an increased risk of diabetic complications, cardiovascular disease, and mortality 3 , 4 , 5 , 6 , 7 , 8 , 9 . In a community‐based survey, a high HGI was associated with an increased risk of arterial hypertension 10 .…”

Section: Introductionmentioning

confidence: 99%

Factors associated with hemoglobin glycation index in adults with type 1 diabetes mellitus: The FGM‐Japan study

Sakane

Hirota

Yamamoto

et al. 2023

J of Diabetes Invest

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Aims/Introduction The discrepancy between HbA1c and glucose exposure may have significant clinical implications; however, the association between the hemoglobin glycation index (HGI) and clinical parameters in type 1 diabetes remains controversial. This study aimed to find the factors associated with HGI (laboratory HbA1c − predicted HbA1c derived from the continuous glucose monitoring [CGM]). Materials and Methods We conducted a cross‐sectional study of adults with type 1 diabetes ( n = 211, age 50.9 ± 15.2 years old, female sex = 59.2%, duration of CGM use = 2.1 ± 1.0 years). All subjects wore the CGM for 90 days before HbA1c measurement. Data derived from the FreeStyle Libre sensor were used to calculate the glucose management indicator (GMI) and glycemic variability (GV) parameters. HGI was defined as the difference between the GMI and the laboratory HbA1c levels. The participants were divided into three groups according to the HGI tertile (low, moderate, and high). Multivariate regression analyses were performed. Results The female sex ratio, HbA1c, and % coefficient of variation (%CV) significantly increased over the HGI tertile, while eGFR and Hb decreased over the HGI tertile. In multivariate analysis, the factors associated with HGI were %CV and eGFR, after adjusting for HbA1c level and sex ( R 2 = 0.44). Conclusions This study demonstrated that HGI is associated with female sex, eGFR, and some glycemic variability indices, independently of HbA1c. Minimizing glycemic fluctuations might reduce HGI. This information provides diabetic health professionals and patients with personalized diabetes management for adults with type 1 diabetes.

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Hemoglobin glycation index is associated with incident chronic kidney disease in subjects with impaired glucose metabolism: A 10-year longitudinal cohort study

Cited by 15 publications

References 36 publications

Correlation Between Hemoglobin Glycosylation Index and Nerve Conduction Velocity in Patients with Type 2 Diabetes Mellitus

Correlation Between Hemoglobin Glycosylation Index and Nerve Conduction Velocity in Patients with Type 2 Diabetes Mellitus

The Relationship Between Hemoglobin Glycation Variation Index and Vitamin D in Type 2 Diabetes Mellitus

Factors associated with hemoglobin glycation index in adults with type 1 diabetes mellitus: The FGM‐Japan study

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