Hemoglobinopatias no Distrito Federal, Brasil

Tavares-Neto, José; Naoum, Paulo Cesar; Adorno, José; Azevêdo, Paula; Brito, Fátima; Caldas, Márcia; Couto, M.F.; Costa, Karina; Martinelli, Cláudio; Gonzalez, Alberto Duarte; Assad, Anna; Mortoza, Luciana; Reis, Fábio Bueno dos; Silva, M.M.C.; Silva, Paulo; Vieira, Marta

doi:10.1590/s0037-86821986000100004

Cited by 2 publications

(1 citation statement)

References 5 publications

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“…A anemia e a doença falciforme são as alterações genéticas mais freqüentes em nosso país 7,21 A prevalência de 5,1% de traço falciforme encontrada nos RN no IMIP apresentou-se acima da relatada por Naoun 24 , que, em levantamento específico da prevalência de traço falciforme por unidade da Federação, apontou a região Norte -Nordeste com as maiores freqüências. Pernambuco apresentou 1,33% entre 451 indivíduos estudados, e a Bahia foi o estado com maior prevalência, ficando com 5,55% entre 1.422 indivíduos analisados.…”

Section: Discussionunclassified

Characteristics of hemoglobin

Bandeira¹,

Gouveia²,

Souza³

et al. 1999

J Pediatr (Rio J)

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Objective: To evaluate the prevalence of Hb S in babies born at the Instituto Materno Infantil de Pernambuco (IMIP) and its occurrence according to sex, birthweight and Apgar.Methods: A cross-sectional descriptive study of all babies born in the IMIP during the period of October/1996 to March/1997 was carried out. Cord blood samples (1,988) were analyzed by alkaline electrophoresis. Data for other infant variables were collected from medical reports. EPI-Info 6.0 was used to analyze the data.Results: We found 105 (5.3%) newborns with the Hb S, as follows: 102 (5.1%.) as sickle cell trait (Hb FAS), and 3 (0.2%) as sickle cell disease (Hb SC). No cases of homozygoses were found. Newborns with and without Hb S did not differ in relation to sex, birthweight and Apgar.Conclusions: We suggest the implementation of a neonatal screening for hemoglobinopathies for all the newborns in Recife, with a further follow up for the suspect or positive cases, focusing on genetic counselling. Resultados: Foram encontrados 105 (5,3%) RN com presença de Hb S. Destes, 102 (5,1%) apresentavam-se na forma de traço falciforme (Hb FAS) e 3 (0,2%) sob a forma de doença falciforme (Hb SC). Não foi encontrado nenhum RN com homozigose para Hb S. Não foi observada diferença estatisticamente significante entre os RN portadores ou não de Hb S quanto ao sexo, peso e Apgar.Conclusões: Sugerimos a realização de triagem neonatal de hemoglobinopatias em todos os RN na cidade de Recife com posterior seguimento dos casos positivos e suspeitos e subseqüente aconselhamento genético às famílias acometidas.J. pediatr. (Rio J.). 1999; 75(3):167-171: recém-nascido, traço falciforme, doença falciforme, triagem neonatal.

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Section: Discussionunclassified

Characteristics of hemoglobin

Bandeira¹,

Gouveia²,

Souza³

et al. 1999

J Pediatr (Rio J)

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Prevalência de hemoglobinas anormais em recém-nascidos da cidade de Natal, Rio Grande do Norte, Brasil

Araújo

Serafim²,

Castro

et al. 2004

Cad. Saúde Pública

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Hemoglobinopathies are among the most prevalent hereditary diseases in humans. Studies in different areas of Brazil have identified the prevalence of S and C abnormal hemoglobins. The study analyzed 1,940 cord blood samples of newborns from maternity hospitals in Natal, Rio Grande do Norte State, to investigate the prevalence of abnormal hemoglobins. All samples were submitted to cellulose acetate electrophoresis using a Tris-EDTA-borate buffer at pH 8.5. Electrophoresis in agar gel pH 6.2 was performed on samples presenting abnormal hemoglobin. Some 37 (1.91%) of the newborns presented hemoglobinopathies, as follows: 29 (1.50%) sickle cell trait (Hb FAS), 6 (0.31%) heterozygous Hb C (Hb FAC), one (0.05%) homozygous Hb S (Hb FS), and one (0.05%) Hb Barts suggestive of alpha thalassemia. The results show the need to implement screening for hemoglobinopathies in the neonatal population.

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Hemoglobinopatias no Distrito Federal, Brasil

Cited by 2 publications

References 5 publications

Characteristics of hemoglobin

Characteristics of hemoglobin

Prevalência de hemoglobinas anormais em recém-nascidos da cidade de Natal, Rio Grande do Norte, Brasil

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