Hemolitic Activity and Sorption Ability of Beta Zeolite Nanoparticles

Ul’yanova, N. Yu.; Kurylenko, L. N.; Shamova, O. V.; Орлов, Д. С.; Golubeva, O. Yu.

doi:10.1134/s108765962002011x

Cited by 9 publications

(3 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Babu et al [52] explored the hemolytic effect of ZnONPs was increased with increasing concentration from 25 to 800 μg/mL in a time-dependent manner. Besides, the data from Ulyanova et al [53] showed that with a decrease in the concentration of nano-zeo to 1 mg/mL, there is a tendency for the hemolytic activity of the samples to decrease. Therefore, the results obtained from this study are consistent with the results of previous studies.…”

Section: Discussionmentioning

confidence: 99%

Enhanced reduction of polymicrobial biofilms on the orthodontic brackets and enamel surface remineralization using zeolite-zinc oxide nanoparticles-based antimicrobial photodynamic therapy

Pourhajibagher

Bahador

2021

BMC Microbiol

View full text Add to dashboard Cite

The aim of this study was to evaluate the anti-biofilm and anti-metabolic activities of zeolite-zinc oxide nanoparticles (Zeo/ZnONPs)-based antimicrobial photodynamic therapy (aPDT) against pre-formed polymicrobial biofilms on the orthodontic brackets, as well as, assess the remineralization efficacy on polymicrobial biofilms induced enamel lesions. Following synthesis and characterization of Zeo/ZnONPs, cell cytotoxicity, hemolytic effect, and intracellular reactive oxygen species (ROS) production were determined. The anti-biofilm and anti-metabolic activities of aPDT using different concentrations of Zeo/ZnONPs were investigated. Microhardness tester and DIAGNOdent Pen were used to evaluate the changes of remineralization degree on the treated enamel slabs duration 1 and 3 months. No significant cytotoxicity and erythrocyte hemolysis were observed in treated cells with Zeo/ZnONPs. When irradiated, suggesting that the Zeo/ZnONPs were photoactivated, generating ROS and leading to reduce dose-dependently the cell viability and metabolic activity of polymicrobial biofilms. Also, the enamel surface microhardness value of exposed enamel showed a steady increase with the concentration of Zeo/ZnONPs. No statistically significant differences were shown between aPDT and sodium fluoride varnish as the control group. Overall, Zeo/ZnONPs-based aPDT with the greatest remineralization efficacy of enamel surface can be used as an anti-biofilm therapeutic method, which is involved with their potent ability to produce ROS.

show abstract

Section: Discussionmentioning

confidence: 99%

Enhanced reduction of polymicrobial biofilms on the orthodontic brackets and enamel surface remineralization using zeolite-zinc oxide nanoparticles-based antimicrobial photodynamic therapy

Pourhajibagher

Bahador

2021

BMC Microbiol

View full text Add to dashboard Cite

show abstract

“…Babu et al 52 explored the hemolytic effect of ZnONPs was increased with increasing concentration from 25 to 800 µg/mL in a time-dependent manner. Besides, the data from Ulyanova et al 53 showed that with a decrease in the concentration of nano-zeo to 1 mg/mL, there is a tendency for the hemolytic activity of the samples to decrease. Therefore, the results obtained from this study are consistent with the results of previous studies.…”

Section: Discussionmentioning

confidence: 99%

Enhanced Reduction of Polymicrobial Biofilms on the Orthodontic Brackets and Enamel Surface Remineralization Using Zeolite-Zinc Oxide Nanoparticles-Based Antimicrobial Photodynamic Therapy

Pourhajibagher

Bahador

2021

Preprint

View full text Add to dashboard Cite

The aim of this study was to evaluate the anti-biofilm and anti-metabolic activities of zeolite-zinc oxide nanoparticles (Zeo\ZnONPs)-based antimicrobial photodynamic therapy (aPDT) against pre-formed polymicrobial biofilms on the orthodontic brackets, as well as, assess the remineralization efficacy on polymicrobial biofilms induced enamel lesions. Following synthesis and characterization of Zeo\ZnONPs, cell cytotoxicity, hemolytic effect, and intracellular reactive oxygen species (ROS) production were determined. The anti-biofilm and anti-metabolic activities of aPDT using different concentrations of Zeo\ZnONPs were investigated. Microhardness tester and DIAGNOdent Pen were used to evaluate the changes of remineralization degree on the treated enamel slabs duration one and three months. No significant cytotoxicity and erythrocyte hemolysis were observed in treated cells with Ze\ZnONPs. When irradiated, suggesting that the Ze\ZnONPs were photoactivated, generating ROS and leading to reduce dose-dependently the cell viability and metabolic activity of polymicrobial biofilms. Also, the enamel surface microhardness value of exposed enamel showed a steady increase with the concentration of Zeo\ZnONPs. No statistically significant differences were shown between aPDT and sodium fluoride varnish as the control group. Overall, Zeo\ZnONPs-based aPDT with the greatest remineralization efficacy of enamel surface can be used as an anti-biofilm therapeutic method, which is involved with their potent ability to produce ROS.

show abstract

“…A simple technology that could produce inorganic nanosponges without the use of toxic reagents would be very useful, especially for potential applications to medicine. Inorganic materials, particularly synthetic aluminosilicates, are generally characterized by low toxicity, depending on the chemical composition, particle size, morphology, and biodegradability (e.g., refs − ). Thus, there is a need for a directed synthesis of inorganic structures with a given set of properties to solve many specific problems in medicine and ecology.…”

Section: Introductionmentioning

confidence: 99%

Aluminosilicate Nanosponges: Synthesis, Properties, and Application Prospects

et al. 2021

View full text Add to dashboard Cite

A simple one-step method is presented for fabricating inorganic nanosponges with a kaolinite [Al2Si2O5(OH)4] structure. The nanosponges were synthesized by the hydrothermal treatment of aluminosilicate gels in an acidic medium (pH = 2.6) at 220 °C without using organic cross-linking agents, such as cyclodextrin or polymers. The formation of the nanosponge morphology was confirmed by scanning electron microscopy, and the assignment of the synthesized aluminosilicates to the kaolinite group was confirmed by X-ray diffraction and infrared spectroscopy. The effect of the synthesis conditions, in particular, the nature (HCl, HF, NaOH, and H2O) and pH of the reaction medium (2.6, 7, and 12), as well as the duration of the synthesis (3, 6, and 12 days), on the morphology of aluminosilicates of the kaolinite group was studied. The sorption capacity of aluminosilicate nanosponges with respect to cationic (e.g., methylene blue) and anionic (e.g., azorubine) dyes in aqueous solutions was studied. The pH sensitivity of the surface ζ potential of the synthesized nanosponges was demonstrated. The dependence of the hemolytic activity (the ability to destroy erythrocytes) of aluminosilicate nanoparticles on the particle morphology (platy, spherical, and nanosponge) has been identified for the first time. Aluminosilicate nanosponges were not found to exhibit hemolytic activity. The prospects of using aluminosilicate nanosponges to prepare innovative functional materials for ecology and medicine applications, in particular, as matrices for drug delivery systems, were identified.

show abstract

Hemolitic Activity and Sorption Ability of Beta Zeolite Nanoparticles

Cited by 9 publications

References 15 publications

Enhanced reduction of polymicrobial biofilms on the orthodontic brackets and enamel surface remineralization using zeolite-zinc oxide nanoparticles-based antimicrobial photodynamic therapy

Enhanced reduction of polymicrobial biofilms on the orthodontic brackets and enamel surface remineralization using zeolite-zinc oxide nanoparticles-based antimicrobial photodynamic therapy

Enhanced Reduction of Polymicrobial Biofilms on the Orthodontic Brackets and Enamel Surface Remineralization Using Zeolite-Zinc Oxide Nanoparticles-Based Antimicrobial Photodynamic Therapy

Aluminosilicate Nanosponges: Synthesis, Properties, and Application Prospects

Contact Info

Product

Resources

About