Hemolymph of molluscan origin: from biochemistry to modern biomaterials science

Machałowski, Tomasz; Jesionowski, Teofil

doi:10.1007/s00339-020-04166-1

Cited by 29 publications

(12 citation statements)

References 187 publications

(283 reference statements)

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“…Hemocytes, as versatile cellular components of hemolymph in mollusks, are responsible for many aspects of molluscan life, such as immune response, biomineralization, cell-cell communication and regeneration [ 62 , 63 ]. Therefore, THC, RB and PA of hemolymph can directly reflect the immunity of the organism.…”

Section: Discussionmentioning

confidence: 99%

Ascorbic Acid Regulates the Immunity, Anti-Oxidation and Apoptosis in Abalone Haliotis discus hannai Ino

Luo

Wang

et al. 2021

Antioxidants

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The present study was conducted to investigate the roles of ascorbic acid (AA) in immune response, anti-oxidation and apoptosis in abalone (Haliotis discus hannai Ino). Seven semi-purified diets with graded levels of AA (0, 50, 100, 200, 500, 1000 and 5000 mg/kg) were fed to abalone (initial weight: 12.01 ± 0.001 g, initial shell length: 48.44 ± 0.069 mm) for 100 days. The survival, weight gain rate and daily increment in shell length were not affected by dietary AA. The AA content in the gill, muscle and digestive glands of abalone was significantly increased by dietary AA. In terms of immunity, dietary AA significantly improved the total hemocyte count, respiratory burst and phagocytic activity in hemolymph, and lysozyme activity in cell-free hemolymph (CFH). In the digestive gland, the TLR-MyD88-dependent and TLR-MyD88-independent signaling pathways were suppressed by dietary AA supplementation. The mRNA levels of β-defensin and arginase-I in the digestive gland were significantly increased by dietary AA. In the gill, only the TLR-MyD88-dependent signaling pathway was depressed by dietary AA to reduce inflammation in abalone. The level of mytimacin 6 in the gill was significantly upregulated by dietary AA. After Vibrio parahaemolyticus infection, the TLR signaling pathway in the digestive gland was suppressed by dietary AA, which reduced inflammation in the abalone. In terms of anti-oxidation, superoxide dismutase, glutathione peroxidase and catalase activities, as well as total anti-oxidative capacity and reduced glutathione content in CFH, were all significantly upregulated. The malondialdehyde content was significantly downregulated by dietary AA. The anti-oxidative capacity was improved by triggering the Keap1-Nrf2 pathway in abalone. In terms of apoptosis, dietary AA could enhance the anti-apoptosis ability via the JNK-Bcl-2/Bax signaling cascade in abalone. To conclude, dietary AA was involved in regulating immunity, anti-oxidation and apoptosis in abalone.

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Section: Discussionmentioning

confidence: 99%

Ascorbic Acid Regulates the Immunity, Anti-Oxidation and Apoptosis in Abalone Haliotis discus hannai Ino

Luo

Wang

et al. 2021

Antioxidants

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“…The mature mother of pearl consists of very thin matrix layers of about 30 nm and thicker layers of calcium carbonate and aragonite—lamellae (about 500 nm). In recent years, scientists have used a number of innovative techniques to simulate the microstructure of the nacre layer and produce materials with good mechanical properties [ 82 , 83 ]. Based on the structure of nacre, Almeida et al produced multifunctional films containing chitosan and hyaluronic acid, developed in dip-coating technology.…”

Section: Biomimetic Materials As Inspiration For Functional Materials...mentioning

confidence: 99%

Chitin and Chitosan as Polymers of the Future—Obtaining, Modification, Life Cycle Assessment and Main Directions of Application

et al. 2023

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Natural polymers are very widespread in the world, which is why it is so important to know about the possibilities of their use. Chitin is the second most abundant reproducible natural polymer in nature; however, it is insoluble in water and basic solvents. Chitin is an unused waste of the food industry, for which there are possibilities of secondary management. The research led to obtaining a soluble, environmentally friendly form of chitin, which has found potential applications in the many fields, e.g., medicine, cosmetics, food and textile industries, agriculture, etc. The deacetylated form of chitin, which is chitosan, has a number of beneficial properties and wide possibilities of modification. Modification possibilities mean that we can obtain chitosan with the desired functional properties, facilitating, for example, the processing of this polymer and expanding the possibilities of its application, also as biomimetic materials. The review contains a rich description of the possibilities of modifying chitin and chitosan and the main directions of their application, and life cycle assessment (LCA)—from the source of the polymer through production materials to various applications with the reduction of waste.

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“…Higher circulating hemocyte levels are present in parasite-infected patients compared to non-infected molluscs. Hemocytes can also aid in wound healing, shell formation, transport of calcium-rich deposits, mineral ions, and calcium-binding proteins ( 51 ).…”

Section: The Immune Response Of Molluscsmentioning

confidence: 99%

Cellular and humoral immune response between snail hosts and their parasites

Al-Khalaifah

2022

Front. Immunol.

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In invertebrates, the innate immune system protects against a wide range of microbiological infections. Several immunological processes are involved in the interactive immune response between snails and their parasites, including phagocytosis, nitric oxide synthesis, phenol oxidase activity, lysozymes, and lectin formation. The immunological responses connected to the interaction between snails and parasites are discussed in detail in the current research. Understanding the nature of these interactive reactions will enable scientists to explore approaches to eliminate and cure parasitic infections.

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Hemolymph of molluscan origin: from biochemistry to modern biomaterials science

Cited by 29 publications

References 187 publications

Ascorbic Acid Regulates the Immunity, Anti-Oxidation and Apoptosis in Abalone Haliotis discus hannai Ino

Ascorbic Acid Regulates the Immunity, Anti-Oxidation and Apoptosis in Abalone Haliotis discus hannai Ino

Chitin and Chitosan as Polymers of the Future—Obtaining, Modification, Life Cycle Assessment and Main Directions of Application

Cellular and humoral immune response between snail hosts and their parasites

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