Poisoning by Plants, Mycotoxins and Related Toxins 2011
DOI: 10.1079/9781845938338.0683
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Hemolytic and spasmolytic assays of Solanum asterophorum Mart. (Solanaceae).

Abstract: Studies were conducted to investigate a possible haemolytic effect on rat erythrocytes and spasmolytic activity on rat aorta and guineapig ileum of a methanol extract obtained from roots of Solanum asterophorum (Sast-MeOHR). A sample of blood was collected from fasting Wistar male rats to obtain erythrocyte suspensions. Sast-MeOHR was added to the suspensions at various concentrations and in different preparations and the percentage of haemolysis was calculated. The spasmolytic activity of the Sast-MeOHR extra… Show more

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“…The hemolytic activity was determined according to a literature method [22]. The red blood cells were diluted in saline solution to obtain a 1% suspension (v/v) and 1.1 mL was mixed with 0.4 mL of xyloglucan solution (0.25-2.0 mg mL −1 in saline).…”
Section: Hemolytic Activity For Toxicity Evaluationmentioning
confidence: 99%
“…The hemolytic activity was determined according to a literature method [22]. The red blood cells were diluted in saline solution to obtain a 1% suspension (v/v) and 1.1 mL was mixed with 0.4 mL of xyloglucan solution (0.25-2.0 mg mL −1 in saline).…”
Section: Hemolytic Activity For Toxicity Evaluationmentioning
confidence: 99%
“…Because some Solanum species have cytotoxic effects, such as Solanum asperum Rich. and S. asterophorum, and present moderate hemolytic activity in rat erythrocytes [27,28], we initially decided to observe the cytotoxic potential and possible acute toxicity of SP-EtOH AP using in vitro and in vivo models, respectively. In the cytotoxicity assay, SP-EtOH AP (125, 250, 500, and 750 µg/ mL, n = 3) did not induce rat erythrocytes lysis (l " Fig.…”
mentioning
confidence: 99%