2012
DOI: 10.1007/s12288-012-0159-6
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Hemolytic Disease of the Newborn Due to Anti-c Isoimmunization: A Case Report

Abstract: The Rhesus (Rh) blood group is one of the most complex blood groups known in humans. It has remained of primary importance in obstetrics, being the main cause of hemolytic disease of the newborn (HDN). Anti-D causes the most severe form of HDN. Other Rh allo antibodies that are capable of causing severe HDN include anti-c, which clinically is the most important Rh antigen after the D antigen. We report a case of hemolytic disease of the newborn due to Rh anti-c in an infant of an Rh positive mother.

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Cited by 15 publications
(12 citation statements)
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“…22 A case of HDFN due to anti-C in Rh-D positive mother has also been reported. 23 Similar incidence has been seen in another study also. 10 We have not observed any of these antibodies except anti-M (4.5%) of the other types of antibodies that are occasionally associated with HDFN (anti Jk a , Jk b , S, etc.,).…”
Section: Discussionsupporting
confidence: 86%
“…22 A case of HDFN due to anti-C in Rh-D positive mother has also been reported. 23 Similar incidence has been seen in another study also. 10 We have not observed any of these antibodies except anti-M (4.5%) of the other types of antibodies that are occasionally associated with HDFN (anti Jk a , Jk b , S, etc.,).…”
Section: Discussionsupporting
confidence: 86%
“…1b), the most frequent RhD negative haplotype is dec [14,39,40], except in Moroccans where haplotype deC is more common. Among RhD positive haplotypes, the ancestral haplotype Dec [39,40] is the most frequent in Africans, whereas in non-African populations haplotype DeC is found at higher frequencies [41]. The dEC haplotype was not found in our population dataset, and DEC was only found at low frequencies in the CHB population.…”
Section: Rhd and Rhce Phenotypes Genotypes And Haplotypescontrasting
confidence: 57%
“…Our study had similar findings, with two of 15 cases receiving treatment for anemia, and both receiving intravenous immunoglobulin (500 mg/kg IV, then repeated 12 hours later). However, there have also been studies and a case report suggesting anti‐c can cause more severe HDFN.…”
Section: Discussionmentioning
confidence: 99%