Hemolytic Reactions Produced in Dogs by Transfusion of Incompatible Dog Blood and Plasma

Yuile, Charles L.; Zandt, Theodore F. Van; Ervin, Donald M.; Young, Lawrence E.

doi:10.1182/blood.v4.11.1232.1232

Cited by 28 publications

(5 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Worth noting are the different sequels to intravascular hemolytic transfusion reactions between animals and people. In cats and dogs, intravascular hemolysis neither causes acute kidney injury nor major vascular compromise in A‐B and other mismatched transfusions or xenotransfusions . Alternatively, when compatible feline blood is not available for an anemic cat, a highly purified polymerized bovine hemoglobin‐based oxygen carrier (eg, Oxyglobin , Dechra Pharmaceuticals PLC, Headquarters , Northwich, UK) may be considered as an alternative to canine xenotransfusion, since it can improve the clinical signs of anemia for at least 24 h and is not associated with exposure of the patient to harmful membranes and other components from lyzed canine erythrocytes …”

Section: Discussionmentioning

confidence: 99%

Xenotransfusion of anemic cats with blood compatibility issues: pre‐ and posttransfusion laboratory diagnostic and crossmatching studies

Euler

Raj

Mizukami

et al. 2016

Veterinary Clinical Pathol

View full text Add to dashboard Cite

Background Finding compatible feline blood donors can be challenging. Canine blood has been occasionally used when compatible feline blood was not available in emergency situations. Objectives The study goals were to describe the effects of xenotransfusion in two anemic cats receiving canine blood because of discordant blood types and acute transfusion reaction, respectively, and to report in vitro heterotyping and – crossmatching results between canine and feline blood samples. Material and Methods Blood samples from patients and other cats and dogs were typed, crossmatched, and assessed for alloantibodies using gel, card, and immunochromatographic strip techniques. Results Cat 1 was found to have type AB blood. Cat 2, which experienced an acute transfusion reaction, had type A blood. Neither had detectable alloantibodies against feline RBC. Both cats transiently improved after transfusion with canine blood, however, acute intravascular hemolysis occurred and the PCV rapidly declined. Blood typing post xenotransfusion with DEA 1 strips revealed a positive control band that was absent in feline blood, thus allowing for the identification of transfused canine RBC. Longitudinal assessment revealed that canine RBC could no longer be detected 4 days after xenotransfusion. Major crossmatching (feline plasma with canine RBC) resulted in both positive and negative reactions, depending on the cat. Minor crossmatching results showed mostly incompatibility. Conclusion While both cats survived xenotransfusion, the positive control band on the DEA 1 strip revealed that transfused canine RBC were short-lived, and intravascular hemolysis occurred. Crossmatch results between cats and dogs showed varied incompatibilities, and may not predict transfusion reactions.

show abstract

Section: Discussionmentioning

confidence: 99%

Xenotransfusion of anemic cats with blood compatibility issues: pre‐ and posttransfusion laboratory diagnostic and crossmatching studies

Euler

Raj

Mizukami

et al. 2016

Veterinary Clinical Pathol

View full text Add to dashboard Cite

show abstract

“…4,13,14,17 Most experimental studies involving incompatible blood transfusions in dogs were published before 1970. 8,27,32,37 –39 Although several recent case reports have documented acute immune-mediated hemolytic transfusion reactions in dogs, notably to DEA 1, DEA 4, and a common antigen not further characterized, 6,14,24 little is known about the production of alloantibodies following sensitization, including the rate of appearance of alloantibodies and their persistence over time.…”

mentioning

confidence: 99%

Characterization of Anti-Dal Alloantibodies Following Sensitization of Two Dal-Negative Dogs

Goulet

Blais

2017

Vet Pathol

View full text Add to dashboard Cite

Since its discovery, the immunogenicity of the Dal blood type has not been further investigated. The aim of this study was to better characterize anti- Dal alloantibodies produced following sensitization of Dal-negative dogs, notably their rate of appearance, the agglutination titer over time, and their immunoglobulin class. A secondary objective was to obtain polyclonal anti- Dal alloantibodies to increase the availability of Dal blood typing. Of 100 healthy laboratory Beagles tested, 2 Dal-negative dogs were identified as recipients. Ten healthy Dal-positive dogs were investigated as potential blood donors. All dogs were extensively blood typed for DEA 1, 3, 4, 5, and 7, as well as for Dal. Then, the recipients were transfused uneventfully with 10 ml/kg of Dal-positive but otherwise compatible packed red blood cells. Posttransfusion blood samples were collected routinely over a minimum of 1 year. Using a gel column technology, anti- Dal alloantibodies were detected as early as 4 days posttransfusion and remained detectable 2 years posttransfusion, with maximum agglutination titers reached at 1 and 2 months posttransfusion. The immunoglobulin class was IgG. The immunogenicity and clinical significance of the Dal blood type were confirmed. The results support the recommendations that previously transfused dogs be crossmatched starting 4 days posttransfusion and for the animal's lifetime. The polyclonal anti- Dal antibodies produced will allow blood typing of a significant number of dogs, especially transfused dogs facing blood incompatibilities and canine blood donors.

show abstract

“…It seems more likely that Yorke and Nauss' success was due to the massive doses of intravenous hemoglobin injected, rather than to the antecedent bleeding. The importance of the observations is questionable since, as pointed out by Yuile et al, equivalent amounts of hemolysis in human beings are unusual (33). In support of the "shock" hypothesis, Corcoran and Page believe that hemorrhagic or tourniquet "shock" capable of producing tubular injury could predispose to hemoglobinuric nephrosis (28).…”

Section: Discussionmentioning

confidence: 99%

The Role of Aciduria in the Development of Hemoglobinuric Nephrosis in Dehydrated Rabbits

Lalich

Schwartz

1950

Journal of Experimental Medicine

View full text Add to dashboard Cite

The effect of acid diets, fasting, and dehydration on the urine pH and the kidneys was determined in 11 control animals. Hyaline casts in the collecting tubules and interstitial medullary edema were observed in the 8 that survived. The test rabbits were subjected to the same treatment as the controls but, in addition, received 1.8 gm./kilo of intravenous homologous hemoglobin. Eleven of 18 animals died of hemoglobinuric nephrosis. The rabbits which died of hemoglobinuric nephrosis exhibited significant alterations in two or more of the following: kidney weight, pigment cast accumulation, and elevations of NPN. The theories which have been advanced to explain the pathogenesis of hemoglobinuric nephrosis are evaluated in the light of the present observations. It is proposed on the basis of them that antecedent tubular damage is of primary importance in the pathogenesis of hemoglobinuric nephrosis.

show abstract

Hemolytic Reactions Produced in Dogs by Transfusion of Incompatible Dog Blood and Plasma

Cited by 28 publications

References 0 publications

Xenotransfusion of anemic cats with blood compatibility issues: pre‐ and posttransfusion laboratory diagnostic and crossmatching studies

Xenotransfusion of anemic cats with blood compatibility issues: pre‐ and posttransfusion laboratory diagnostic and crossmatching studies

Characterization of Anti-Dal Alloantibodies Following Sensitization of Two Dal-Negative Dogs

The Role of Aciduria in the Development of Hemoglobinuric Nephrosis in Dehydrated Rabbits

Contact Info

Product

Resources

About