Hemolytic uremic syndrome associated with<i>Acinetobacter hemolyticus</i>

Silva, Paulo Sérgio Lucas da; Lipinski, Rubens Wolfe

doi:10.3109/0886022x.2014.917575

Cited by 6 publications

(5 citation statements)

References 18 publications

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“…Besides, several previous studies have revealed that Bifidobacterium and Lactobacillus are significantly decreased in CKD and uremia (Bobrov & Karpov, 1993;Miu, Bilev, & Iua, 2008). Acinetobacter is associated with hemolytic uremic syndrome (Da & Lipinski, 2014), and B. cereus is another motile, aerobic and Gram positive bacterium associated with hemolytic uremic syndrome (Oroujzadeh, Gholivand, & Jamalabadi, 2017), which are consistent with our findings. In the current study, Gubenxiezhuo dialysis could significantly attenuate the upregulation of Acinetobacter, B. cereus, P. vulgaris, S. flexneri, and E. coli, and the downregulation of Bifidobacterium, Lactobacillus and…”

supporting

confidence: 92%

Influence of colonic dialysis using Gubenxiezhuo on the distribution of gut microflora in uremia rats

Tang

et al. 2018

Journal Cellular Physiology

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Objective This study aimed to explore the underlying function of Gubenxiezhuo dialysis on the distribution of gut microflora uremia. Methods A uremia rat model was constructed, and the morphology of renal tissue was determined using the hematoxylin‐eosin (H&E) staining. Moreover, the blood samples were collected and the expression of IL‐1β, IL‐6, and CRP was determined using enzyme‐linked immunosorbent assay. Following these experiments, the gut tissues of rats were collected and the distribution of gut microbiota was explored using real‐time PCR. Results Compared with the control group, inflammatory infiltration, apoptosis, and bleeding were significantly upregulated in kidney of uremia rats, and Gubenxiezhuo dialysis could obviously ameliorate these changes. Expression of IL‐1β, IL‐6, and CRP were significantly elevated in uremic rats and Gubenxiezhuo could significantly attenuate these elevations (p < 0.01). In addition, Gubenxiezhuo dialysis also could attenuate the upregulations of Acinetobacter, Bacillus cereus, Proteus vulgaris, Shigella flexneri, and Escherichia coli , and the downregulation of Bifidobacterium, Lactobacillus, and Helicobacter in the uremia rats ( p < 0.05). Conclusion Gubenxiezhuo dialysis could significantly ameliorate the inflammatory to modulate the distribution of gut microbiota in uremia.

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supporting

confidence: 92%

Influence of colonic dialysis using Gubenxiezhuo on the distribution of gut microflora in uremia rats

Tang

et al. 2018

Journal Cellular Physiology

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“…Correspondingly, we found that after DF intervention, the abundance of some potential pathogenic bacteria decreased. These species included Acinetobacter and Ruminococcaceae , which are related to infection, hemolysis and anorexia nervosa [ 34 , 35 ]. However, we found that the relative abundance of Blautia, which is a BA-producing bacterium, was decreased in the DF group, but the serum BA level was elevated.…”

Section: Discussionmentioning

confidence: 99%

The prebiotic effects of soluble dietary fiber mixture on renal anemia and the gut microbiota in end-stage renal disease patients on maintenance hemodialysis: a prospective, randomized, placebo-controlled study

Han

Song

et al. 2022

J Transl Med

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Background Renal anemia is caused by end-stage renal disease (ESRD) but has a complex etiology. The application of dietary fiber (DF) to regulate the gut microbiota has shown effective therapeutic effects in some diseases, but its role in renal anemia is not clear. The aim of this study was to explore the effect of DF on renal anemia by regulating the gut microbiota and its metabolite, short-chain fatty acids (SCFAs). Methods A total of 162 ESRD patients were enrolled and randomly distributed into a DF or a control group (received oral DF or potato starch, 10 g/day for 8 weeks). Hemoglobin (Hb), serum iron (Fe2+), serum ferritin (SF), soluble transferrin receptor (sTfR), hepcidin and the dosage of recombinant human erythropoietin (rhEPO) before and after intervention in patients were analyzed. The gut microbiota and SCFAs in both groups were analyzed by 16S rDNA sequencing and gas chromatography–mass spectrometry, respectively. Spearman’s correlation test was used to analyze the correlation between the gut microbiota, SCFAs and the hematological indicators. Results Compared with the control group, (1) the patients in the DF group had higher Hb [117.0 (12.5) g/L vs. 94.0 (14.5) g/L, p < 0.001], Fe2+ [13.23 (4.83) μmol/L vs. 10.26 (5.55) μmol/L, p < 0.001], and SF levels [54.15 (86.66) ng/ml vs. 41.48 (36.60) ng/ml, p = 0.003]. (2) The rhEPO dosage in the DF group was not significantly decreased (p = 0.12). (3) Bifidobacterium adolescentis, Lactobacillus and Lactobacillaceae were increased in the DF group, and Lactobacillus and Lactobacillaceae were positively correlated with Hb (r = 0.44, p < 0.001; r = 0.44, p < 0.001) and Fe2+ levels (r = 0.26, p = 0.016; r = 0.26, p = 0.016) and negatively correlated with rhEPO dosage (r = − 0.45, p < 0.001; r = − 0.45, p < 0.001). (4) Patients in the DF group had elevated serum butyric acid (BA) levels [0.80 (1.65) vs. 0.05 (0.04), p < 0.001] and BA levels were positively correlated with Hb (r = 0.26, p = 0.019) and Fe2+ (r = 0.31, p = 0.005) and negatively correlated with rhEPO dosage (r = − 0.36, p = 0.001). Lactobacillus and Lactobacillaceae were positively correlated with BA levels (r = 0.78, p < 0.001; r = 0.78, p < 0.001). Conclusion DF may improve renal anemia in ESRD patients by regulating the gut microbiota and SCFAs. Trial registration This study was registered in the China Clinical Trial Registry (www.chictr.org.cn) on December 20, 2018 (ChiCTR1800020232).

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“…Conventionally, E. coli and S. dysenteriae type-1 strains are considered to be the major carriers of Shiga toxins; however, these toxins have also been described in several other bacterial genera and species, including Shigella flexneri, Shigella sonnei, Citrobacter spp., Aeromonas spp., Acinetobacter haemolyticus, Salmonella spp., Vibrio vulnificus, and Campylobacter spp. [58][59][60][61][62][63][64][65][66][67], among others, with each of these representing emerging and growing public health risks.…”

Section: Shiga-toxin-producing Bacteriamentioning

confidence: 99%

“…For instance, in 2006, Grotiuz [64] reported the first Stx2-positive Acinetobacter hemolyticus strain from an infant with bloody diarrhea. Later, in 2014, another Stx-positive A. hemolyticus strain was identified as the causative agent of HUS in a 9-month-old infant [65]. Beyond Acinetobacter, after screening 278 bacterial isolates that were positive for the eae gene, Ooka et al [66] identified two strains of E. albertii, one isolated from a diarrheal patient and the other from a healthy bird, that harbored an stx2 gene belonging to the stx 2f subtype.…”

Section: Other Bacteriamentioning

confidence: 99%

A Comprehensive Review on Shiga Toxin Subtypes and Their Niche-Related Distribution Characteristics in Shiga-Toxin-Producing E. coli and Other Bacterial Hosts

Wang,

Yu,

Chui

et al. 2024

Microorganisms

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Shiga toxin (Stx), the main virulence factor of Shiga-toxin-producing E. coli (STEC), was first discovered in Shigella dysenteriae strains. While several other bacterial species have since been reported to produce Stx, STEC poses the most significant risk to human health due to its widespread prevalence across various animal hosts that have close contact with human populations. Based on its biochemical and molecular characteristics, Shiga toxin can be grouped into two types, Stx1 and Stx2, among which a variety of variants and subtypes have been identified in various bacteria and host species. Interestingly, the different Stx subtypes appear to vary in their host distribution characteristics and in the severity of diseases that they are associated with. As such, this review provides a comprehensive overview on the bacterial species that have been recorded to possess stx genes to date, with a specific focus on the various Stx subtype variants discovered in STEC, their prevalence in certain host species, and their disease-related characteristics. This review provides a better understanding of the Stx subtypes and highlights the need for rapid and accurate approaches to toxin subtyping for the proper evaluation of the health risks associated with Shiga-toxin-related bacterial food contamination and human infections.

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Hemolytic uremic syndrome associated withAcinetobacter hemolyticus

Cited by 6 publications

References 18 publications

Influence of colonic dialysis using Gubenxiezhuo on the distribution of gut microflora in uremia rats

Influence of colonic dialysis using Gubenxiezhuo on the distribution of gut microflora in uremia rats

The prebiotic effects of soluble dietary fiber mixture on renal anemia and the gut microbiota in end-stage renal disease patients on maintenance hemodialysis: a prospective, randomized, placebo-controlled study

A Comprehensive Review on Shiga Toxin Subtypes and Their Niche-Related Distribution Characteristics in Shiga-Toxin-Producing E. coli and Other Bacterial Hosts

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