Hemoperfusion Through Dna-Coated and Uncoated Synthetic Activated Charcoals as an Additive to the Bronchial Asthma Traditional Treatment

Abstract

In this study the single session of small-volume (31) direct hemoperfusion (DHP) through uncoated (I group, 24 patients) and DNA-coated (II group, 17 patients) synthetic activated carbons has been investigated as an additive to the traditional medicamental treatment (III group, 22 patients) of the endogenous bronchial asthma. Significant amelioration of the main clinical and immunological indices in the patients of the I and II group in comparison with those of III group was noted. Between two DHP-including treatment modalities hemoimmunosorption onto DNA-coated activated charcoal is suggested as better.

Activated Carbon for Sepsis Prevention and Intervention: A Modern Way of Utilizing Old Therapies

“…Effective reduction of such complexes has become possible with the development of carbon adsorbents with tailored porosity features such as fractality [17,57,58]. AC coated [59] and/or grafted with different ligands [18,60] acquires new properties like adsorption selectivity and improved biocompatibility. AC becomes bi-functional and permits the simultaneous withdrawal of the target substances by coupling with the ligand and by a broad range (non-selective) adsorption of PAMPs and DAMPs (Table 1).…”

“…For example, the combination of selective adsorption by such ligands as DNA or dextran sulfate fixed on AC with non-selective adsorption of activated charcoal (AC) ameliorates adsorption of DNA-binding substances and proinflammatory cytokines, compared to uncoated AC [18]. DNA-containing activated charcoal for direct hemoperfusion in a clinical trial of bronchial asthma treatment appeared to be more effective than the same uncoated AC [60]. The inhibitory properties of highly activated AC against the development of infection caused by herpes simplex virus were enhanced by the antiviral drug acyclovir (ACV) adsorbed on AC.…”