Hemophagocytic lymphohistiocytosis

Gowarty, Jasmine; Oda, Julie Massayo Maeda; Cable, Christian

doi:10.1080/08998280.2018.1446877

Cited by 3 publications

(2 citation statements)

References 8 publications

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“…Published cases of parvovirus B19 complicated by HLH are summarized in Table 1. Hemolytic diseases such as hereditary spherocytosis (42)(43)(44)(45), sickle cell disease (40), alpha thalassemia ( 47), glucose-6-phosphate dehydrogenase deficiency (46), and autoimmune hemolytic anemia (41) were the most frequently reported primary disease. Also, a third of patients were immunocompromised, including patients with acquired immune deficiency syndrome (50), autoimmune diseases (37-39), undergoing chemotherapy (48), and post-transplantation patients (24)(25)(26), which can lead to persistent parvovirus B19 infection and may cause pure red cell aplasia.…”

Section: Discussionmentioning

confidence: 99%

Case Report: Parvovirus B19 infection complicated by hemophagocytic lymphohistiocytosis in a heart-lung transplant patient

et al. 2023

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Immunosuppressed patients can contract parvovirus B19, and some may experience hemophagocytic lymphohistiocytosis (HLH). Herein, we describe the first report of hemophagocytic lymphohistiocytosis in a heart-lung transplant patient with concomitant parvovirus B19 infection. The patient was treated with intravenous immune globulin (IVIG) and the features of HLH were remission. This instance emphasizes the significance of parvovirus B19 monitoring in transplant patients with anemia; if HLH complicates the situation, IVIG may be an adequate remedy. Finally, a summary of the development in diagnosing and managing parvovirus B19 infection complicated by HLH is provided.

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Section: Discussionmentioning

confidence: 99%

Case Report: Parvovirus B19 infection complicated by hemophagocytic lymphohistiocytosis in a heart-lung transplant patient

et al. 2023

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“…In addition, the patient was positive for parvovirus B19. They treated him with steroids, which resulted in remarkable improvement [ 12 ]. Among the bacterial causes, tuberculosis and gram-negative organisms have been implicated [ 10 - 11 ].…”

Section: Discussionmentioning

confidence: 99%

Report of a Fatal Case of Hemophagocytic Lymphohistiocytosis Syndrome and a Review of the Literature

Khan

Ansar²,

Kontos

et al. 2020

Cureus

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Kikuchi's disease with hemophagocytic lymphohistiocytosis

et al. 2020

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Introduction: Kikuchi's disease (KD) is a rare form of necrotizing lymphadenitis that rarely occurs in association with hemophagocytic lymphohistiocytosis (HLH) in children. Patient concerns: We report the case of a 4-year-5-month-old boy who suffered from fever, cervical lymphadenopathy, pancytopenia, hypertriglyceridemia, splenomegaly, low NK cell activity. Diagnoses: A diagnosis of KD with HLH was made based on the results of biopsy of cervical lymph node and HLH-2004 trial guidelines. Interventions: The patient was treated with corticosteroids, cyclosporine, etoposide, continuous hemodiafiltration (HDF), and plasma exchange (PE). Outcomes: He showed a complete response to therapy, and his condition gradually improved. He was discharged on day 45 after admission due to his good recovery status. Conclusion: HLH can be associated with KD, especially in childhood, and may have an aggressive clinical course. Continuous HDF and PE and chemotherapy should be reserved for those patients who fail to respond to IVIG and corticosteroids.

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Hemophagocytic lymphohistiocytosis

Cited by 3 publications

References 8 publications

Case Report: Parvovirus B19 infection complicated by hemophagocytic lymphohistiocytosis in a heart-lung transplant patient

Case Report: Parvovirus B19 infection complicated by hemophagocytic lymphohistiocytosis in a heart-lung transplant patient

Report of a Fatal Case of Hemophagocytic Lymphohistiocytosis Syndrome and a Review of the Literature

Kikuchi's disease with hemophagocytic lymphohistiocytosis

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