Hemophagocytic lymphohistiocytosis associated with parvovirus B19-induced aplastic crisis in a hereditary spherocytosis patient: A case report and literature review

Kim, Ki Tae; Hong, Kyung Taek; Kim, Bo Kyung; An, Hong Yul; Choi, Jung Yoon; Chang, Yoon Hwan; Kang, Hyoung Jin

doi:10.1080/08880018.2021.1949082

Cited by 3 publications

(1 citation statement)

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“…Published cases of parvovirus B19 complicated by HLH are summarized in Table 1 . Hemolytic diseases such as hereditary spherocytosis ( 42 – 45 ), sickle cell disease ( 40 ), alpha thalassemia ( 47 ), glucose-6-phosphate dehydrogenase deficiency ( 46 ), and autoimmune hemolytic anemia ( 41 ) were the most frequently reported primary disease. Also, a third of patients were immunocompromised, including patients with acquired immune deficiency syndrome ( 50 ), autoimmune diseases ( 37 – 39 ), undergoing chemotherapy ( 48 ), and post-transplantation patients ( 24 – 26 ), which can lead to persistent parvovirus B19 infection and may cause pure red cell aplasia.…”

Section: Discussionmentioning

confidence: 99%

Case Report: Parvovirus B19 infection complicated by hemophagocytic lymphohistiocytosis in a heart-lung transplant patient

et al. 2023

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Immunosuppressed patients can contract parvovirus B19, and some may experience hemophagocytic lymphohistiocytosis (HLH). Herein, we describe the first report of hemophagocytic lymphohistiocytosis in a heart-lung transplant patient with concomitant parvovirus B19 infection. The patient was treated with intravenous immune globulin (IVIG) and the features of HLH were remission. This instance emphasizes the significance of parvovirus B19 monitoring in transplant patients with anemia; if HLH complicates the situation, IVIG may be an adequate remedy. Finally, a summary of the development in diagnosing and managing parvovirus B19 infection complicated by HLH is provided.

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