Hemophagocytic lymphohistiocytosis secondary to disseminated histoplasmosis in systemic lupus erythematosus

Filho, João Tadeu Damian Souto; Lima, Priscilla Damião Araújo; Paulo, Alex Batista; Souza, Ana Luisa Silva

doi:10.1007/s12185-017-2308-z

Cited by 7 publications

(3 citation statements)

References 7 publications

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“…3 HLH causing DAH due to disseminated histoplasmosis in patients with SLE has been reported very rarely, with only two cases found in published literature. 4 Our patient was started on amphotericin B which led to a rapid improvement in her condition. Current recommendations include completing antifungal treatment for at least a year.…”

Section: Discussionmentioning

confidence: 83%

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A rare case of hemophagocytic lymphohistiocytosis mimicking flare of systemic lupus erythematosus

Tiwana

Wang

et al. 2023

Respirology Case Reports

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The Ohio and Mississippi River Valleys are endemic to histoplasmosis. It is usually self‐limiting in immunocompetent people, but it can cause morbidity and mortality if not detected early in people with an underlying autoimmune disease. Disseminated Histoplasmosis induced hemophagocytic lymphohistiocytosis (HLH) mimicking the flare of an underlying autoimmune disease, is uncommon in the published literature. Disseminated histoplasmosis (DH) can cause multiorgan involvement, especially in a patient with an underlying autoimmune disease. We present the case of a 24‐year‐old female with HLH who was initially treated as a flare of autoimmune disease but later etiology was confirmed as disseminated histoplasmosis on bone marrow histopathological examination.

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Section: Discussionmentioning

confidence: 83%

“…HLH causing DAH due to disseminated histoplasmosis in patients with SLE has been reported very rarely, with only two cases found in published literature. 4 …”

Section: Discussionmentioning

confidence: 99%

A rare case of hemophagocytic lymphohistiocytosis mimicking flare of systemic lupus erythematosus

Tiwana

Wang

et al. 2023

Respirology Case Reports

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“…Interestingly, HLH secondary to disseminated histoplasmosis in systemic lupus erythematosus [3] or in patients with human immunodeficiency virus (HIV) [4,5] has been described. Moreover, from the newest immunomodulatory monoclonal antibodies, the drug daratumumab has been implicated for inducing HLH as well [6].…”

Section: Introductionmentioning

confidence: 99%

Hemophagocytic Lymphohistiocytosis as a Manifestation of Underlying Visceral Leishmaniasis

Diamantidis

Palioura

Ιωάννου

et al. 2020

Cureus

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Hemophagocytic lymphohistiocytosis (HLH), or hemophagocytic syndrome (HS) is a severe syndrome involving an extreme participation of the immune system, resulting in a cascade of cytokines, hyperinflammation and extensive hemophagocytosis in the bone marrow (BM) and affecting the peripheral blood (PB) lineages. Fever, splenomegaly, hypertriglyceridemia, hypofibrinogenemia, and hyperferritinemia are often encountered in this disease. The syndrome can be seen in all ages and it is either primary due to genetic defects or secondary because of malignancies, immune deficiencies, rheumatic diseases, and infections. Bacteria, viruses, protozoa, and fungi are often implicated. Visceral leishmaniasis (VL) is among the infectious causes of HLH. We describe a patient with a successful treatment of HLH after the initiation of liposomal amphotericin B, due to VL, even though there was a delay in diagnosing the leishmaniasis. The exact precipitating pathophysiological events triggering HLH remain unknown and provide their clear impact for future research. An instructive, critical review of the literature related to the presented case is provided. Distinguishing secondary HS from primary HS is essential for the application of suitable treatment. Improper use of corticosteroids could cover up an underlying possible malignancy or infection and delay the initiation of the etiologic therapeutic strategy.

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Progressive and disseminated histoplasma infection and hemophagocytic lymphohistiocytosis in an immunocompetent adult

Dousa

Hoz

Church

et al. 2019

Clinical Case Reports

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Hemophagocytic lymphohistiocytosis secondary to disseminated histoplasmosis in systemic lupus erythematosus

Cited by 7 publications

References 7 publications

A rare case of hemophagocytic lymphohistiocytosis mimicking flare of systemic lupus erythematosus

A rare case of hemophagocytic lymphohistiocytosis mimicking flare of systemic lupus erythematosus

Hemophagocytic Lymphohistiocytosis as a Manifestation of Underlying Visceral Leishmaniasis

Progressive and disseminated histoplasma infection and hemophagocytic lymphohistiocytosis in an immunocompetent adult

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