Hemorheology, Sickle Cell Trait, and α-Thalassemia in Athletes: Effects of Exercise

Monchanin, Géraldine; Connes, Philippe; Wouassi, Dieudonné; Francina, Alain; Djoda, Bernard; Banga, P. E.; Owona, F.-X.; Thiriet, Patrice; Massarelli, R.; Martin, Cyril

doi:10.1249/01.mss.0000170128.78432.96

Cited by 53 publications

(74 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Patients with α thalassemia and on hydroxyurea therapy were excluded from the present study since they are known to have abnormal RBC rheology. [9][10][11][12] All subjects provided informed consent and the ethics committee of the Academic Hospitals of Pointe-à-Pitre approved the study.…”

Section: Subjects and Blood Samplingmentioning

confidence: 99%

Red blood cell aggregation, aggregate strength and oxygen transport potential of blood are abnormal in both homozygous sickle cell anemia and sickle-hemoglobin C disease

Tripette¹,

Alexy²,

et al. 2009

View full text Add to dashboard Cite

BackgroundRecent evidence suggests that red blood cell aggregation and the ratio of hematocrit to blood viscosity (HVR), an index of the oxygen transport potential of blood, might considerably modulate blood flow dynamics in the microcirculation. It thus seems likely that these factors could play a role in sickle cell disease. Design and MethodsWe compared red blood cell aggregation characteristics, blood viscosity and HVR at different shear rates between sickle cell anemia and sickle cell hemoglobin C disease (SCC) patients, sickle cell trait carriers (AS) and control individuals (AA). ResultsBlood viscosity determined at high shear rate was lower in sickle cell anemia (n=21) than in AA (n=52), AS (n=33) or SCC (n=21), and was markedly increased in both SCC and AS. Despite differences in blood viscosity, both sickle cell anemia and SCC had similar low HVR values compared to both AA and AS. Sickle cell anemia (n=21) and SCC (n=19) subjects had a lower red blood cell aggregation index and longer time for red blood cell aggregates formation than AA (n=16) and AS (n=15), and a 2 to 3 fold greater shear rate required to disperse red blood cell aggregates. ConclusionsThe low HVR levels found in sickle cell anemia and SCC indicates a comparable low oxygen transport potential of blood in both genotypes. Red blood cell aggregation properties are likely to be involved in the pathophysiology of sickle cell disease: the increased shear forces needed to disperse red blood cell aggregates may disturb blood flow, especially at the microcirculatory level, since red blood cell are only able to pass through narrow capillaries as single cells rather than as aggregates.Key words: sickle cell disease, red blood cell aggregation, viscosity, red blood cell deformability. Citation: Tripette J, Alexy T, Hardy-Dessources M-D, Mougeneld D, Beltan E, Chalabi T, Chout

show abstract

Section: Subjects and Blood Samplingmentioning

confidence: 99%

Red blood cell aggregation, aggregate strength and oxygen transport potential of blood are abnormal in both homozygous sickle cell anemia and sickle-hemoglobin C disease

Tripette¹,

Alexy²,

et al. 2009

View full text Add to dashboard Cite

show abstract

“…Blood flow is also deeply affected by blood apparent viscosity (Poiseuille's law). Several studies have thus far shown the presence of lower RBC deformability and higher blood apparent viscosity among SCT carriers compared with HbAA control (C) subjects (9,18,19,47). Furthermore, the lower RBC deformability of SCT carriers could lead to endothelial damage, activation of endothelial cells, and thus promote endothelial cell-blood cell interactions, leading to inflammation.…”

mentioning

confidence: 99%

Remodeling of skeletal muscle microvasculature in sickle cell trait and α-thalassemia

Vincent

Féasson

Oyono-Enguéllé

et al. 2010

American Journal of Physiology-Heart and Circulatory Physiology

Self Cite

View full text Add to dashboard Cite

The influence of sickle cell trait and/or α-thalassemia on skeletal muscle microvascular network characteristics was assessed and compared with control subjects [hemoglobin (Hb) AA] in 30 Cameroonian residents [10 HbAA, 5 HbAA α-thalassemia (α-t), 6 HbAS, and 9 HbASα-t] matched for maximal work capacity and daily energy expenditure. Subjects performed an incremental exercise to exhaustion and underwent a muscle biopsy. Muscle fiber type and surface area were not different among groups. However, sickle cell trait (SCT) was associated with lower capillary density ( P < 0.05), lower capillary tortuosity ( P < 0.001), and enlarged microvessels ( P < 0.01). SCT carriers had reduced counts of microvessels <5-μm diameter, but a higher percentage of broader microvessels, i.e., diameter >10 μm ( P < 0.05). α-Thalassemia seemed to be characterized by a higher capillary tortuosity and unchanged capillary density and diameter. Thus, while SCT is a priori clinically benign, we demonstrate for the first time that significant remodeling of the microvasculature occurs in SCT carriers. These modifications may possibly reflect protective adaptations against hemorheological and microcirculatory dysfunction induced by the presence of HbS. The remodeling of the microvascular network occurs to a lesser extent in α-thalassemia. In α-thalassemic subjects, increased capillary tortuosity would promote oxygen supply to muscle tissues and might compensate for the lower Hb content often reported in those subjects.

show abstract

“…A test of solubility confirmed the presence of Hb S. Positive test results for SCT were determined by the presence of Hb S (Ͻ50%) and a normal percentage of Hb A2 (16). Hb concentration, hematocrit (Hct), percentage of reticulocytes, and mean corpuscular volume were also studied for the indirect diagnosis of anemia and ␣-thalassaemia, which results in hematological modifications (20,26).…”

Section: Sct Diagnosis and Blood Analysismentioning

confidence: 99%

“…The physical and physiological behavior of exercising SCT carriers (AS) remains equivocal, and controversial data have been documented. Although the presence of Hb S should result in lower aerobic capacity, most studies have reported similar aerobic performances in AS and controls (1,13,20,24). Impaired O 2 delivery to muscles from AS RBCs during exercise could result in a greater participation of anaerobic metabolism in exercising muscles.…”

mentioning

confidence: 99%

Faster lactate transport across red blood cell membrane in sickle cell trait carriers

Farhang¹,

Connes²,

Hue³

et al. 2006

Journal of Applied Physiology

View full text Add to dashboard Cite

show abstract

Hemorheology, Sickle Cell Trait, and α-Thalassemia in Athletes: Effects of Exercise

Cited by 53 publications

References 25 publications

Red blood cell aggregation, aggregate strength and oxygen transport potential of blood are abnormal in both homozygous sickle cell anemia and sickle-hemoglobin C disease

Red blood cell aggregation, aggregate strength and oxygen transport potential of blood are abnormal in both homozygous sickle cell anemia and sickle-hemoglobin C disease

Remodeling of skeletal muscle microvasculature in sickle cell trait and α-thalassemia

Faster lactate transport across red blood cell membrane in sickle cell trait carriers

Contact Info

Product

Resources

About