Hemorragia pulmonar y hemotórax tras ingesta masiva de clopidogrel con fines autolíticos

Clau, Luis Borderías; López, Javier Garrapiz; Caballero, Gonzalo

doi:10.1016/j.arbres.2009.06.009

Cited by 5 publications

(4 citation statements)

References 5 publications

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“…There might be some propensity towards pleural bleeding, with or without pulmonary bleeding, with clopidogrel use. A case published in the Spanish literature in 2009 reported a patient with pulmonary and pleural hemorrhage after massive clopidogrel intake as a suicidal attempt [12], which makes one wonder why bleeding occurred specifically in these body organs. Similarly, another case published in the Spanish literature in 2006 reported spontaneous, massive bilateral hemothoraces in a patient who took dual anti-platelet therapy of aspirin and clopidogrel after a coronary DES placement [13].…”

Section: Discussionmentioning

confidence: 99%

Acute Hemothorax Causing Hemorrhagic Shock Following Small-bore Thoracocentesis in a Patient on Clopidogrel: A Case Report and Literature Review

Asmar¹,

Zeid²

2020

Cureus

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Clopidogrel is one of the most commonly prescribed thienopyridines used postcoronary stenting for acute coronary syndrome (ACS). There have been several concerns regarding performing small-bore thoracocentesis on patients on clopidogrel in our practice. We present an 85-year-old male with a history of diabetes, atrial fibrillation, diastolic heart failure, chronic kidney disease (CKD) stage three, who recently had a non-ST elevation myocardial infarction (NSTEMI) requiring a drug-eluting stent (DES) to the left anterior descending (LAD) artery, and was on dual anti-platelet therapy (DAPT). He was admitted with worsening shortness of breath and found to have bilateral pleural effusions. He required several small-bore, ultrasoundguided thoracocentesis on the right side while on clopidogrel. Intensivists or residents did all the procedures. The patient went into a hemorrhagic shock following his third small-bore thoracocentesis, requiring pressors, blood and platelet transfusions, and a surgical intercostal (IC) drain insertion. He eventually became clinically stable. An IC arteriogram within 24 h ruled out IC artery injury. Healthcare professionals perceive small-bore thoracocentesis as a safe procedure done on medical, surgical, intensive care, and interventional radiology (IR) units. The overall consensus is that it is safe to perform it on patients taking clopidogrel. We emphasize through this case report the bleeding risks associated with performing such procedures on patients while on clopidogrel and considering holding clopidogrel when feasible or bridging with an intravenous anti-platelet drug.

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Section: Discussionmentioning

confidence: 99%

Acute Hemothorax Causing Hemorrhagic Shock Following Small-bore Thoracocentesis in a Patient on Clopidogrel: A Case Report and Literature Review

Asmar¹,

Zeid²

2020

Cureus

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“…Bronchogenic carcinoma is the leading cause of tumor-related deaths in developed countries [3]. Adenocarcinoma accounts for approximately one-third of the lung carcinomas that metastasize to the ovary.…”

Section: Discussionmentioning

confidence: 99%

“…Metastatic lung adenocarcinomas mimic ovarian surface epithelial-stromal tumors, such as the endometrioid, serous, clear cell, and mucinous type [6]. The ovary is an uncommon location for metastasis of lung cancer, and few such cases have been reported in the literature [3, 7–9]. Young and Scully reported 7 cases of ovarian metastasis of lung cancer [10].…”

Section: Discussionmentioning

confidence: 99%

“…Tumors may spread to the ovary via a blood-borne or lymphatic route, transperitoneally, or by direct extension. Differentiating between primary ovarian carcinoma and metastatic carcinoma is very important because the treatment regimen and prognosis are markedly different for each [3]. A multidisciplinary approach that includes clinical, serological, pathological, and radiological assessments is necessary in these cases.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Ovarian Metastasis from Lung Cancer: A Rare Entity

Cengiz

Yıldız

Kaya

et al. 2013

Case Reports in Obstetrics and Gynecology

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This paper describes a case of ovarian metastasis from lung carcinoma along with its diagnostic challenges, clinical management, and review of the literature. A 49-year-old woman was admitted to our emergency department with complaints of abdominal pain and vomiting. A laparoscopic appendectomy was performed due to acute appendicitis, and a unilateral oophorectomy (left side) via laparoscopy was performed due to the detection of an ovarian mass. Immunohistochemical staining of the ovarian mass revealed that it was reactive to cytokeratin-7 (CK-7) but negative for CK-20. The immunohistochemical and pathological features of the tumor indicated an ovarian metastasis of non-small-cell lung cancer. The patient underwent chemotherapy and was followed up by the oncology department. Her postoperative regular followup of 6 months showed that her condition was stable with no recurrence. The management of female patients with acute abdominal pain and pelvic masses should consist of a multidisciplinary approach to include the diagnosis of any distant organ metastasis.

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Drugs that affect blood coagulation, fibrinolysis, and hemostasis

Aronson¹

2011

Side Effects of Drugs Annual

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Hemorragia pulmonar y hemotórax tras ingesta masiva de clopidogrel con fines autolíticos

Cited by 5 publications

References 5 publications

Acute Hemothorax Causing Hemorrhagic Shock Following Small-bore Thoracocentesis in a Patient on Clopidogrel: A Case Report and Literature Review

Acute Hemothorax Causing Hemorrhagic Shock Following Small-bore Thoracocentesis in a Patient on Clopidogrel: A Case Report and Literature Review

Ovarian Metastasis from Lung Cancer: A Rare Entity

Drugs that affect blood coagulation, fibrinolysis, and hemostasis

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