Hemorrhagic Complications of Dental Extractions in 181 Patients Undergoing Double Antiplatelet Therapy

Olmos-Carrasco, Olga; Pastor-Ramos, Victoria; Espinilla-Blanco, Rafael; Ortiz-Zárate, Ana; García-Ávila, Irene; Rodríguez-Alonso, Elías; Herrero-Sanjuán, Rosario; Ruiz-García, María-Magdalena; Gallego-Beuter, Paloma; Sánchez-Salgado, María-Paz; Terán-Agustín, Ana-Isabel; Fernández-Behar, Milagros; Peña-Sainz, Inmaculada

doi:10.1016/j.joms.2014.08.011

Cited by 36 publications

(18 citation statements)

References 24 publications

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“…Bleeding after dental extractions is sometimes affected by pharmacologic therapies like antiplatelet/anticoagulant/anti-hypertensive drugs; literature reports show that dental extraction can be performed safely in patients treated with antiplatelet therapy [32] without withdrawal therapy because the suspension of antiplatelet therapy puts the patient at a higher risk of cardiovascular events [33,34] than the intervention itself. In this study patients on antiplatelet or anticoagulant drugs or suffering from hypertension were 18.1%, 7.9%, and 33.8%, respectively, and the reported percentage of hemorrhage was 0.4%.…”

Section: Discussionmentioning

confidence: 99%

Factors Influencing the Onset of Intra- and Post- Operative Complications Following Tooth Exodontia: Retrospective Survey on 1701 Patients

et al. 2019

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Complications after tooth extraction may occur because of several factors correlated to the patient's medical history, surgical site or type of intervention. The aim of this retrospective cohort study was to evaluate type and frequency of complications after exodontic surgery, its correlation with antibiotic administration and between patient's related systemic factors. From June 2015 until February 2016 1701 exodontic interventions, for a total of 2322 extracted teeth, were carried out at the Unit of Oral Surgery in Trieste. Descriptive statistic, and backward multiple logistic regressions were performed to identify the variables associated with the presence of post-operative alveolitis or any other post-operative complication. The presence of coagulopathy and smoking habit were related to high risk of post-operative alveolitis (OR = 5.51, p = 0.035 and OR = 2.5, p = 0.029, respectively). Tooth fracture was found to be correlated with higher probability of post-operative alveolitis (p = 0.001) and concomitant chemotherapy put at a higher risk post-operative complications, including alveolitis (OR = 29.5, p = 0.018). According to the present results, antibiotic consumption did not seem to reduce the incidence of post-operative infective complications (alveolitis). A careful analysis of medical history, the adequate surgical technique, and the correct instructions in post-surgical behavior, prevent the insurgence of intra and post-operative complications.

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Section: Discussionmentioning

confidence: 99%

Factors Influencing the Onset of Intra- and Post- Operative Complications Following Tooth Exodontia: Retrospective Survey on 1701 Patients

et al. 2019

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“…Pour l'ensemble de ces études cliniques [24,36,48,50,54,56,113,185,197,204,228,234,248,281], aucune complication hémorragique sévère non contrôlable par des mesures d'hémostase locale n'est rapportée. Deux études [212,237] ont évalué la perte sanguine après extraction dentaire chez des patients sous aspirine ou clopidogrel comparativement à des patients ne prenant pas d'aspirine ou ayant interrompu leur traitement par AAP 7 jours avant la procédure dentaire ou sous AINS.…”

Section: Arrêt Ou Maintien Du Traitement Par Agent Antiplaquettaire ?unclassified

“…En revanche, en cas d'association aspirine + clopidogrel, le risque de saignement, durant la période postopératoire immédiate est plus élevé en cas de bithérapie comparativement à l'aspirine seule (RR 28, p < 0,001) et au clopidogrel (RR 24, p < 0,001) [54,197] mais facilement contrôlable par des mesures d'hémostase locale [36,54,197,227,228,234]. Aucune hémorragie sévère ou tardive n'est rapportée.…”

Section: Arrêt Ou Maintien Du Traitement Par Agent Antiplaquettaire ?unclassified

“…Aframian, 2007 [1], Ardekian, 2000 [24], Bajkin, 2012 [35], Bajkin, 2015[36], Brennan,2008[49],Canigral,2008 [54]Cardona-Tortajada, 2009 [56], Garnier, 2007 [113], Iwabuchi, 2014 [173], Krishman, 2008 [185], Lillis, 2011 [197], Madan, 2010 [204],] Medeiros, 2011 [212], Moritomoto, 2008a [223], Morimoto, 2011 [225], Napenas, 2009 [227], Olmos-Carrasco, 2015 [234], Park, 2012 [239], Partridge, 2008 [237], Rai, 2013 [248], van Diermen, 2009 [278], Verma, 2013 [280], Verma, 2014 [281] Etape 3 «Antiplatelet» OU " «Aspirin» OU «Dipyridamol» OU «Ticlopidin»OU«Clopidogrel»OU«Prasugrel»OU«Ticagrelor» "ET" « Dental implant »…”

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confidence: 99%

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Gestion péri-opératoire des patients traités par antithrombotiques en chirurgie orale. Argumentaire

2015

Med Buccale Chir Buccale

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“…When surgery is performed in these patients, even minor oral surgery, discon-tinuation of anticoagulant therapy should be avoided to prevent the onset of thrombosis. Previous reports recommend continuing an anticoagulant therapy during tooth extraction to prevent thrombophilia in patients receiving long-term anticoagulant therapy (9)(10)(11). Patients with APS also receive high-dose glucocorticoids to control severe polyarthritis; in some patients bisphosphonates are administered to prevent steroidal osteoporosis.…”

Section: Introductionmentioning

confidence: 99%

Oral surgery in patients with antiphospholipid syndrome

et al. 2019

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Antiphospholipid syndrome (APS) is a systemic autoimmune disorder characterized by recurrent thrombosis, other associated autoimmune disease, and/or obstetrical morbidity along with persistent production of antiphospholipid antibodies. Because of the nature of this systemic disease, most patients are medicated with antithrombotic agents and abundant glucocorticoids. This study reports a cohort of 16 patients with APS, who underwent oral surgery between 2010 and 2017 at the Nagasaki University Hospital. Because oral antithrombotic therapy was continued in the perioperative period, all wounds were strictly closed by suturing to prevent postoperative bleeding. Perioperative laboratory dates and medications were assessed. All patients achieved local postoperative hemostasis and did not exhibit systemic complications. Moreover, there were no postoperative systemic and/or local infections. Oral surgeons should suture oral wounds and ensure local hemostasis to prevent postoperative bleeding. Because patients with APS are likely to develop thrombosis despite continued administration of antithrombotic medications, strict perioperative examination of blood coagulation is needed. Furthermore, it is important to consider the damage and stress caused due to oral surgery. Moreover, when necessary, glucocorticoid therapy should be carefully administered, in accordance with the degree of invasion and judgment of the attending physician.

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Hemorrhagic Complications of Dental Extractions in 181 Patients Undergoing Double Antiplatelet Therapy

Cited by 36 publications

References 24 publications

Factors Influencing the Onset of Intra- and Post- Operative Complications Following Tooth Exodontia: Retrospective Survey on 1701 Patients

Factors Influencing the Onset of Intra- and Post- Operative Complications Following Tooth Exodontia: Retrospective Survey on 1701 Patients

Gestion péri-opératoire des patients traités par antithrombotiques en chirurgie orale. Argumentaire

Oral surgery in patients with antiphospholipid syndrome

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