Hemorrhagic disease in dogs infected with an unclassified intraendothelial piroplasm in southern Brazil

Loretti, Alexandre Paulino; Barros, Severo Sales de

doi:10.1016/j.vetpar.2005.07.011

Cited by 66 publications

(94 citation statements)

References 24 publications

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“…This is consistent with the hemolytic condition caused by the parasite. Immune-mediated hemolytic anemia (IMHA) with spherocytes is commonly associated with canine rangeliosis (LORETTI & BARROS, 2005). In this study, the presence of non-regenerative anemia in a large number of the R. vitalii-infected animals (20/36) was an uncommon finding in comparison with the data in the literature.…”

Section: Discussionmentioning

confidence: 62%

“…The exoerythrocytic cycle presented by R. vitalii can cause lesions in many tissues, thus resulting in circulating cells with phagocytic properties, such as macrophages (LORETTI & BARROS, 2005;FIGHERA et al, 2010). This may explain the increase in the number of macrophages and activated monocytes in peripheral circulation in the CBC of the dogs of this study.…”

Section: Discussionmentioning

confidence: 99%

“…Other abnormalities that have been reported include anisocytosis, polychromasia, Howell-Jolly bodies and reticulocytes (LORETTI & BARROS, 2004;LORETTI & BARROS, 2005;FIGHERA, 2007).…”

Section: Introductionmentioning

confidence: 99%

“…To date, R. vitalii has only been described in Brazil, Uruguay and Argentina (LORETTI & BARROS, 2005;EIRAS et al, 2014;SOARES et al, 2015). This protozoon can be seen as free forms in plasma and in erythrocytes, monocytes and endothelial cell cytoplasm, within cerebral capillaries and in the aorta and jugular vein (LORETTI & BARROS, 2005). It is easier to view the parasite during fever peaks in blood smears (PESTANA, 1910b;SILVA et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

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Clinical and hematological evaluation of Rangelia vitalii-naturally infected dogs in southeastern Brazil

Lemos

Toma

Assad

et al. 2017

Rev. Bras. Parasitol. Vet.

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Rangelia vitalii, a tick-borne piroplasm that infects dogs, has been recently molecularly characterized in Brazil, Uruguay and Argentina. Studies on molecular characterization of these piroplasms in different Brazilian regions are scarce. The aim of this study was to evaluate clinical and hematological changes in dogs caused by R. vitalii in the mountainous region of the state of Rio de Janeiro. Blood samples from 36 dogs were evaluated for piroplasms and hematological disorders using light microscopy and molecular analysis. Blood samples from all the animals included in this study were confirmed to be positive for R. vitalii through genetic sequencing. Clinical signspresented by 24 of the 36 dogs of the study were evaluated during appointments or hospitalization within private practice. The most frequent clinical disorders in these dogs that were naturally infected with R. vitalii were fever, spontaneous cutaneous bleeding and diarrhea. Normochromic non-regenerative anemia and thrombocytopenia were the most common hematological disorders in these R. vitalii-positive dogs and therefore should be considered in hematological evaluations on suspected cases.Keywords: Piroplasm, Rangelia vitalii, dogs, PCR, hematological evaluation. ResumoRangelia vitalii, um piroplasma transmitido por carrapatos que infecta cães, foi sendo recentemente caracterizado molecularmente no Brasil, Uruguai e Argentina. Nas diferentes regiões brasileiras são escassos os estudos acerca da caracterização molecular destes piroplasmídeos. O objetivo deste estudo foi avaliar as alterações clínicas e hematológicas em cães causadas por R. vitalii na região serrana do Rio de Janeiro. Amostras de sangue total de 36 cães foram examinadas quanto à presença de piroplasmas pela microscopia de luz, alterações hematológicas e análise molecular. Todos os cães do presente estudo foram positivos para R. vitalii através do sequenciamento genético. Dos 36 animais positivos para R. vitalii, 24 foram avaliados clinicamente. As alterações mais frequentemente observadas foram febre, sangramento cutâneo espontâneo e diarréia. Anemia normocítica normocrômica arregenerativa e trombocitopenia foram as alterações hematológicas mais observadas em cães positivos para R. vitalii, devendo ser consideradas na avaliação hematológica de cães suspeitos.

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Section: Discussionmentioning

confidence: 62%

Section: Discussionmentioning

confidence: 99%

“…Other abnormalities that have been reported include anisocytosis, polychromasia, Howell-Jolly bodies and reticulocytes (LORETTI & BARROS, 2004;LORETTI & BARROS, 2005;FIGHERA, 2007).…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Clinical and hematological evaluation of Rangelia vitalii-naturally infected dogs in southeastern Brazil

Lemos

Toma

Assad

et al. 2017

Rev. Bras. Parasitol. Vet.

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“…O ciclo de vida deste protozoário consiste no estágio de desenvolvimento eritrocítico e na forma exoeritrocitária, ocorrendo no citoplasma de neutrófilos, monócitos e células endoteliais (FHIGERA et al, 2010;SOARES et al, 2011;DA SILVA et al, 2011). Na fase aguda da doença são encontrados principalmente no sangue circulante e encontrados, também, em corte histológico de fígado, baço, pulmão, rim e medula óssea (LORETTI; BARROS, 2005). O agente etiológico pode ser facilmente encontrado, pois ocorre em grande quantidade na maioria dos tecidos, principalmente nos linfonodos, no baço, na medula óssea, no coração e nas tonsilas (FHIGERA et al, 2010).…”

Section: Cães De áReas Rurais E Urbanas Podem Apresentar O Parasitismunclassified

Clinical, hematological, parasitological and pathoanatomical profiles of Rangelia vitalii infection in a dog: a case report

Silveira¹,

Lacerda²,

D'Avila³

et al. 2015

Pubvet

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Canine rangeliosis: the need for differential diagnosis

et al. 2012

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Rangeliosis is a hemoparasitosis that affects dogs in Brazil. The disease has similar clinical and pathological characteristics to other hemo-protozoan infections. So, this paper has aimed to report a clinical case of infection by Rangelia vitalii in one dog, focusing on the need for the differential diagnosis to other infectious diseases. The animal showed apathy, anemia, thrombocytopenia, alteration of leucogram, and bleeding. The first difference was the observation of parasites in blood smears, where R. vitalii was visualized within leukocytes and erythrocytes. The confirmation of the clinical diagnosis was made by molecular test to R. vitalii. The dog was debilitated, and died a few hours after treatment at the veterinary hospital. At necropsy, splenomegaly, lymphadenopathy, and mild jaundice in the abdominal viscera were found. This article draws attention to the need for the parasitological, serological, and molecular to differential diagnosis in order to differentiate from other clinically similar disorders.

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Hemorrhagic disease in dogs infected with an unclassified intraendothelial piroplasm in southern Brazil

Cited by 66 publications

References 24 publications

Clinical and hematological evaluation of Rangelia vitalii-naturally infected dogs in southeastern Brazil

Clinical and hematological evaluation of Rangelia vitalii-naturally infected dogs in southeastern Brazil

Clinical, hematological, parasitological and pathoanatomical profiles of Rangelia vitalii infection in a dog: a case report

Canine rangeliosis: the need for differential diagnosis

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