Hemorrhagic Fever in Cochabamba, Bolivia, 1971

Peters, C. J.; Kuehne, Ralph W.; Mercado, Rodríguez; Bow, R. H. Le; Spertzel, Richard O.; Webb, P. A.

doi:10.1093/oxfordjournals.aje.a121631

Cited by 87 publications

(50 citation statements)

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“…The dramatic difference in rates of infection between the two groups led to control of BHF by eliminating rodents that invaded towns (Peters, 2006). Subsequent cases have provided evidence for human-to-human transmission (Douglas and Couch, 1965;Peters et al, 1974;Kilgore et al, 1995). BHF patients resemble AHF patients in most manifestations.…”

Section: Bolivian Hemorrhagic Fevermentioning

confidence: 98%

Diseases of the central nervous system caused by lymphocytic choriomeningitis virus and other arenaviruses

Wilson¹,

Peters²

2014

Neurovirology

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Section: Bolivian Hemorrhagic Fevermentioning

confidence: 98%

Diseases of the central nervous system caused by lymphocytic choriomeningitis virus and other arenaviruses

Wilson¹,

Peters²

2014

Neurovirology

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“…1,19,23 Infection can also occur between caregivers and afflicted patients from close contact, and caregiver transmission has been reported during more than 1 outbreak. 7,20 The incubation period for BHF in humans can vary from 5 to 21 days but generally is between 7 and 14 days. Initial signs of infection include fever, lethargy, anorexia, dehydration, cutaneous hyperesthesia, myalgia, back pain, headache, and dizziness.…”

mentioning

confidence: 99%

“…Complete recovery takes several weeks to months with convalescence often marred by fatigue, dizziness, hair loss, and Beau lines in the patient's finger-and toenails. 1,6,7,19,20,27,29 Many aspects of BHF are poorly understood, and an animal model would facilitate pathogenesis studies, therapeutic testing, and vaccines trials. Animal models are needed to study MACV because the sporadic and often secluded nature of outbreaks, in combination with its highly lethal nature, makes it neither feasible nor ethical to do such testing in human subjects.…”

mentioning

confidence: 99%

Pathogenesis of Bolivian Hemorrhagic Fever in Guinea Pigs

et al. 2015

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Machupo virus, the cause of Bolivian hemorrhagic fever, is a highly lethal viral hemorrhagic fever with no Food and Drug Administration-approved vaccines or therapeutics. This study evaluated the guinea pig as a model using the Machupo virusChicava strain administered via aerosol challenge. Guinea pigs (Cavia porcellus) were serially sampled to evaluate the temporal progression of infection, gross and histologic lesions, and sequential changes in serum chemistry and hematology. The incubation period was 5 to 12 days, and complete blood counts revealed leukopenia with lymphopenia and thrombocytopenia. Gross pathologic findings included congestion and hemorrhage of the gastrointestinal mucosa and serosa, noncollapsing lungs with fluid exudation, enlarged lymph nodes, and progressive pallor and friability of the liver. Histologic lesions consisted of foci of degeneration and cell death in the haired skin, liver, pancreas, adrenal glands, lymph nodes, tongue, esophagus, salivary glands, renal pelvis, small intestine, and large intestine. Lymphohistiocytic interstitial pneumonia was also present. Inflammation within the central nervous system, interpreted as nonsuppurative encephalitis, was histologically apparent approximately 16 days postexposure and was generally progressive. Macrophages in the tracheobronchial lymph node, on day 5 postexposure, were the first cells to demonstrate visible viral antigen. Viral antigen was detected throughout the lymphoid system by day 9 postexposure, followed by prominent spread within epithelial tissues and then brain. This study provides insight into the course of Machupo virus infection and supports the utility of guinea pigs as an additional animal model for vaccine and therapeutic development.

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“…50 Like filoviruses, person-to-person transmission of the arenaviruses occurs predominantly by direct contact with infectious blood and bodily fluids. A number of nosocomial outbreaks of Lassa fever [51][52][53] and of New World arenaviruses 54 have occurred via this mechanism. As with filoviruses, person-toperson airborne transmission has been suspected in a few instances.…”

Section: Filoviridae: Ebola and Marburgmentioning

confidence: 99%

“…54,57 However, Lassa fever virus can be detected in semen up to 3 months after acute infection 58 and in urine 32 days after disease onset, 59 and Argentine hemorrhagic fever has been transmitted to spouses of convalescent patients 7 to 22 days after onset of illness. …”

Section: Filoviridae: Ebola and Marburgmentioning

confidence: 99%

Hemorrhagic Fever Viruses as Biological Weapons: Medical and Public Health Management

&NA;

2002

Infectious Diseases in Clinical Practice

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Hemorrhagic Fever in Cochabamba, Bolivia, 1971

Cited by 87 publications

References 0 publications

Diseases of the central nervous system caused by lymphocytic choriomeningitis virus and other arenaviruses

Diseases of the central nervous system caused by lymphocytic choriomeningitis virus and other arenaviruses

Pathogenesis of Bolivian Hemorrhagic Fever in Guinea Pigs

Hemorrhagic Fever Viruses as Biological Weapons: Medical and Public Health Management

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