Hemorrhagic fever with renal syndrome in Albania. Focus on predictors of acute kidney injury in HFRS

Rista, Elvana; Pilaca, Arben; Rama, Ariol; Harja, Endri; Puca, Edmond; Bino, Silvia; Cadri, Vilma; Kota, Majlinda; Thereska, Nestor; Harxhi, Arjan

doi:10.1016/j.jcv.2017.03.021

Cited by 14 publications

(12 citation statements)

References 10 publications

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“…The key feature is renal involvement; however, several extra-renal manifestations have also been reported. As reported elsewhere, males have predominance compared to females [2,3,5,10], in this study the M:F ratio was 8:1. AP was observed with HFRS progression in approximately 10% of cases in this study.…”

Section: Discussionsupporting

confidence: 79%

“…The causative agents of HFRS are hantaviruses, which belong to the genus Hantavirus, family Bunyaviridae, the most common are: Hantaan virus (HTNV), Amur virus (AMV), Seoul virus (SEOV), Dobrava virus (DOBV), and Puumala virus (PUUV) [1][2][3]. Hantaviruses cause two diseases, typified by HFRS in Eurasia and hantavirus cardio-pulmonary syndrome (HCPS) in the Americas.…”

Section: Introductionmentioning

confidence: 99%

“…Hantaviruses cause two diseases, typified by HFRS in Eurasia and hantavirus cardio-pulmonary syndrome (HCPS) in the Americas. Hantaviruses are usually transmitted to humans through aerosolized excrements from rodents, rodents are assymptomatic carriers with lifelong infections [1][2][3][4]. The physiopathology of hantavirus infection is not completely understood, however capillary endothelium injury occurs which increases vascular permeability.…”

Section: Introductionmentioning

confidence: 99%

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Pancreatitis in patients with hemorrhagic fever with renal syndrome: A five-year experience

Puca¹,

Harxhi²,

Pipero³

et al. 2017

J Infect Dev Ctries

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Introduction: Pancreatitis is a rare complication of hemorrhagic fever with renal syndrome (HFRS). The causative agents of HFRS are hantaviruses, which belong to the genus Hantavirus, family Bunyaviridae. The purpose of this study was to evaluate cases of acute pancreatitis (AP) in patients with HFRS at the Service of Infectious Diseases, Tirana, Albania. Methodology: In this retrospective study, clinical and laboratory data was obtained from 36 patients with confirmed HFRS, between January 2011 and December 2016. The diagnosis had been confirmed by a positive enzyme-linked immunosorbent assay (ELISA) for IgM or IgG antibodies to hantavirus. Results: The average patient age was 39.7 ± 14.1 years with a range of 15-59 years. From 36 HFRS patients, four (11.1%) were found to have AP, all were male. Abdominal pain was the most common symptom and an increase in amylase and lipase was observed in all four patients. Abdominal computed tomography (CT) indicated pancreatitis with surrounding edema, necrosis and hemorrhage. In this study, the total mortality was 11.1% (4/36), while mortality in patients with AP was 25% (1/4). Conclusions: The results indicate that AP is a serious complication of HFRS, with a poor prognosis. Increased awareness of AP in clinicians and assessment of amylasemia or lipasemia in patients with HFRS should be considered, especially in endemic areas where a rapid diagnosis is crucial for a positive outcome.

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Section: Discussionsupporting

confidence: 79%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Pancreatitis in patients with hemorrhagic fever with renal syndrome: A five-year experience

Puca¹,

Harxhi²,

Pipero³

et al. 2017

J Infect Dev Ctries

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“…HFRS is an important rodent-borne disease characterized by fever, haemorrhage, kidney disease, headache, back pain, abdominal pain and hypotension 2 – 4 . Severe HFRS can develop into five phases: the febrile, hypotensive (shock), oliguric, diuretic and convalescent phases 5 . Human beings are infected by hantaviruses through the inhalation of aerosolized excreta (including faeces, urine and saliva) from infected animals 1 , 6 .…”

Section: Introductionmentioning

confidence: 99%

Spatial-temporal characteristics and the epidemiology of haemorrhagic fever with renal syndrome from 2007 to 2016 in Zhejiang Province, China

Wang

Xue

et al. 2018

Sci Rep

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Zhejiang Province is one of the six provinces in China that has the highest incidence of haemorrhagic fever with renal syndrome (HFRS). Data on HFRS cases in Zhejiang Province from January 2007 to July 2017 were obtained from the China Information Network System of Disease Prevention and Control. Joinpoint regression analysis was used to observe the trend of the incidence rate of HFRS. The monthly incidence rate was predicted by autoregressive integrated moving average(ARIMA) models. Spatial autocorrelation analysis was performed to detect geographic clusters. A multivariate time series model was employed to analyze heterogeneous transmission of HFRS. There were a total of 4,836 HFRS cases, with 15 fatal cases reported in Zhejiang Province, China in the last decade. Results show that the mean absolute percentage error (MAPE) of the modelling performance and the forecasting performance of the ARIMA model were 27.53% and 16.29%, respectively. Male farmers and middle-aged patients account for the majority of the patient population. There were 54 high-high clusters and 1 high-low cluster identified at the county level. The random effect variance of the autoregressive component is 0.33; the spatio-temporal component is 1.30; and the endemic component is 2.45. According to the results, there was obvious spatial heterogeneity in the endemic component and spatio-temporal component but little spatial heterogeneity in the autoregressive component. A significant decreasing trend in the incidence rate was identified, and obvious clusters were discovered. Spatial heterogeneity in the factors driving HFRS transmission was discovered, which suggested that a targeted preventive effort should be considered in different districts based on their own main factors that contribute to the epidemics.

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“…Hantaan and Dobrava virus infections usually cause severe symptoms, while Seoul, Saaremaa, and Puumala virus infections are usually more moderate [4]. Cases with hemorrhagic fever with renal syndrome in Albania are caused by Dobrava strains [5]. Albania, a part of Balkans, is part of an endemic area [6].…”

Section: Introductionmentioning

confidence: 99%

Posterior Reversible Encephalopathy Syndrome in a Patient with Hemorrhagic Fever with Renal Syndrome

Muco

Hasa

Rroji

et al. 2020

Case Reports in Infectious Diseases

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We presently report the case of hantavirus infection in a 45-year-old male who was hospitalized to our clinic of infectious diseases, with fever, myalgia, vomiting, nausea, headache, and abdominal pain. The physical findings included hepatomegaly, splenomegaly, rash, and conjunctival injection. Eight days before the start of complaints, the patient has cut trees in the mountain. An acute renal failure was observed with an oliguria and an increase of serum creatinine and blood urea nitrogen. Urinalysis shows albuminuria and hematuria. Elevations of amylase, lipase, and liver enzymes levels, low serum albumin level, and thrombocytopenia were observed. A positive ELISA test for hantavirus IgM/IgG antibodies confirmed hemorrhagic fever with renal syndrome. On the third day of hospitalization, the patient had seizures. The unenhanced head computed tomography (CT) performed after seizures showed subcortical bilateral hypodensities within frontal, parietal, and occipital regions corresponding to areas of increased signal intensity in magnetic resonance imaging (MRI) associated with cerebral edema in posterior reversible encephalopathy syndrome (PRES). The treatment consisted of supportive therapy. The patient underwent another head MRI with contrast enhancement after 2 months, which resulted normal.

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Hemorrhagic fever with renal syndrome in Albania. Focus on predictors of acute kidney injury in HFRS

Cited by 14 publications

References 10 publications

Pancreatitis in patients with hemorrhagic fever with renal syndrome: A five-year experience

Pancreatitis in patients with hemorrhagic fever with renal syndrome: A five-year experience

Spatial-temporal characteristics and the epidemiology of haemorrhagic fever with renal syndrome from 2007 to 2016 in Zhejiang Province, China

Posterior Reversible Encephalopathy Syndrome in a Patient with Hemorrhagic Fever with Renal Syndrome

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