Hemorrhagic Stroke

Boccardi, Edoardo; Cenzato, Marco; Curto, Francesco Lo; Longoni, Marco; Motto, Cristina; Oppo, Valentina; Perini, Valentina; Vidale, Simone

doi:10.1007/978-3-319-32130-1

Cited by 8 publications

(9 citation statements)

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“…Stroke merupakan penyebab kematian nomer dua di dunia dan penyebab utama disabilitas .1 Stroke perdarahan adalah kegawadaruratan yang harus didiagnosis dan ditangani tepat waktu karena tingginya resiko kemunduran klinis pada satu jam pertama setelah onset. 2 Perdarahan intraserebral (PIS) adalah tipe stroke penyumbang morbiditas tertinggi, 3 DAFTAR PUSTAKA…”

Section: Pendahuluanunclassified

Pengembangan dan Validasi Skor Luaran Disabilitas Pasien Perdarahan Intraserebral di RS Bethesda Yogyakarta

Secoadi¹,

Pinzon

Pramudita

2020

JKA

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Perdarahan Intraserebral (PIS) adalah tipe stroke penyumbang morbiditas tertinggi. Pertanyaan tentang prognosis sering muncul dari keluarga maupun tim perawat untuk menetapkan intervensi yang tepat dan memastikan tujuan perawatan. Berdasarkan hal tersebut, perlu dikembangkan model skala yang dapat secara akurat memprediksi PIS sesuai dengan demografik dan keparahan pasien. Tujuan: Mengukur faktor-faktor determinan yang dapat mempengaruhi disabilitas pasien PIS sehingga dapat menentukan luaran disabilitas pasien PIS menggunakan pengembangan skor prediktor. Metode: Penelitian ini menggunakan metode kohort retrospektif dari stroke registry dan rekam medis pasien perdarahan intraserebral di Rumah Sakit Bethesda Yogyakarta. Analisis data terdiri dari analisis deskriptif meliputi karakteristik sampel penelitian dan analisis statistik meliputi analisis bivariat dengan menggunakan uji Chi-square, multivariat dengan menggunakan uji regresi logistik dan uji validitas menggunakan kurva ROC serta untuk cut-off point menggunakan AUC. Hasil: Terdapat variabel yang berhubungan dengan morbiditas pada pasien perdarahan intraserebral yaitu usia (OR:3.590, 95%CI:1.285-10.028, p:0.015) dan onset (OR:2.253, 95%CI:1.049-4.836, p:0.037). Setiap variabel memiliki skor masing-masing untuk menentukan luaran disabilitas pasien perdarahan intraserebral (AUC:0.655, 95%CI:0.557-0.754, p:0.004). Simpulan: Skor prediktor (usia dan onset) dapat digunakan secara valid untuk meramalkan disabilitas pasien perdarahan intraserebral.Kata kunci: perdarahan intraserebral, skor luaran disabilitas, usia dan onset

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Section: Pendahuluanunclassified

Pengembangan dan Validasi Skor Luaran Disabilitas Pasien Perdarahan Intraserebral di RS Bethesda Yogyakarta

Secoadi¹,

Pinzon

Pramudita

2020

JKA

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“…For a patient with ICH-like symptoms, immediate medical service needs to be provided to determine the location, subtype, and possible cause of bleeding, so that the appropriate medical treatment can be initiated. Common causes of ICH include physical trauma (Perel et al 2009), bloodthinning medication (FDA 2012, Ferreira da Silva and Provencio 2015), ruptured aneurysm (Brandt et al 1987, Nowak et al 1998, and those factors associated with hemorrhagic strokes (Boccardi et al 2017). Some non-hemorrhagic strokes (e.g.…”

Section: Introductionmentioning

confidence: 99%

Task-driven optimization of the non-spectral mode of photon counting CT for intracranial hemorrhage assessment

Zhang

Chen

et al. 2019

Phys. Med. Biol.

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Non-contrast CT (NCCT) is widely employed as the first-line imaging test to evaluate intracranial hemorrhage (ICH). Advances in mutidetector CT (MDCT) technology have greatly improved the image quality of NCCT for the detection of established, relatively large, and acute ICHs. Meanwhile, the reliability of MDCT in detecting microbleeds and chronic hemorrhage, and in predicting hemorrhagic transformation needs to be further improved. The purpose of this work was to investigate the potential use of non-spectral photon counting CT (PCCT) to address these challenges in ICH imaging. Towards this goal, the NCCT protocol of an experimental PCCT system that simulates the geometry of a general-purpose MDCT was optimized. The optimization was driven by three imaging tasks: detection of a 4.0 mm intraparenchymal hemorrhage, detection of a 1.5 mm subarachnoid hemorrhage, and discrimination of a sulcus in the insular cortex from the parenchymal background. These imaging tasks were custom-built into an anthropomorphic head phantom. Under the guidance of the frequency-dependent noise equivalent quanta and the ideal observer model detectability index d′, the optimal PCD detection mode, energy threshold, and reconstruction kernel were found to be the anti-charge sharing mode, 15 keV, and an apodized ramp kernel, respectively. Compared with a clinical MDCT operated with an ICH protocol and at a matched dose level, the PCCT system provided at least 20% improvements in d′ for all three ICH imaging tasks. These results demonstrated the potential benefits of non-spectral PCCT in ICH assessment.

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“…1-2 Angka insiden kejadian berkisar 24,6 per 100.000 penduduk dan semakin meningkat seiring bertambahnya usia seseorang. 3…”

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Hubungan Kadar Glial Fibrillary Acidic Protein (Gfap) Serum Dengan Luaran Klinis Neurologis Pasien Stroke Hemoragik

Hendartono

Retnaningsih

Husni

2018

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THE CORRELATION BETWEEN SERUM LEVELS OF GLIAL FIBRILLARY ACIDIC PROTEIN (GFAP) WITH NEUROLOGICAL CLINICAL OUTCOME OF HEMORRHAGIC STROKE PATIENTABSTRACTIntroduction: Glial fibrillary acidic protein (GFAP) is a protein that is responsible for the cytoskeleton structure of glial cells. Increased level of GFAP can be used to predict the level of glial cells damage that accompanies a hemorrhagic stroke. National Institute of Health Stroke Scale (NIHSS) and modified Rankin Scale (mRS) are the measurement scales that have high validity and reliability for determining the long-term functional clinical output of hemorrhagic stroke patients.Aims: To determine the correlation between serum levels of GFAP with neurological clinical outcome of hemorrhagic stroke patients.Methods: Prospective cohort study were conducted at Dr. Kariadi Hospital Semarang in the period of July- November 2018. Serum blood sampling for GFAP examination was carried out in less than 72 hours from the stroke onset. Then the third and seventh day NIHSS and 30-day mRS were assessed. Statistical analyses were performed to assess the correlation between serum levels of GFAP with neurological clinical outcome of hemorrhagic stroke patients.Results: The study found 33 subjects of hemorrhagic stroke patients. Multivariate analysis showed that the serum GFAP levels were significant for NIHSS changes (p=0.003; OR=1.397). Significant differences were also obtained at serum GFAP levels with 30-day mRS (p=0.009; OR=1.603).Discussion: Serum GFAP levels taken in less than 72 hours from the hemorrhagic stroke onset are associated with neurological clinical outcome of hemorrhagic stroke patients.Keywords: Glial fibrillary acidic protein, hemorrhagic stroke, modified Rankin Scale, National Institute of Health Stroke ScaleABSTRAKPendahuluan: Glial fibrillary acidic protein (GFAP) merupakan protein yang bertanggung jawab terhadap struktur sitoskeleton dari sel glia. Peningkatan kadar GFAP dapat digunakan untuk memprediksi tingkat kerusakan sel glia yang menyertai stroke hemoragik. National Institute of Health Stroke Scale (NIHSS) dan modified Rankin Scale (mRS) merupakan skala pengukuran yang memiliki validitas dan reliabilitas yang tinggi untuk penentuan luaran klinis fungsional jangka panjang pasien stroke hemoragik.Tujuan: Mengetahui hubungan kadar GFAP serum dengan luaran klinis neurologis pasien stroke hemoragik.Metode: Penelitian kohort prospektif yang dilakukan di RSUP Dr. Kariadi Semarang selama bulan Juli-November 2018. Pengambilan sampel darah serum untuk pemeriksaan GFAP dilakukan dalam <72 jam pertama onset stroke. Kemudian dinilai skor NIHSS hari ketiga, NIHSS hari ketujuh dan mRS hari ke-30. Data diolah dan dilakukan analisis statistik untuk menilai hubungan kadar GFAP serum dengan luaran klinis neurologis pasien stroke hemoragik.Hasil: Pada penelitian didapatkan 33 subjek pasien stroke hemoragik. Analisis multivariat didapatkan kadar GFAP serum bermakna secara signifikan terhadap perubahan NIHSS (p=0,003; RO=1,397). Perbedaan yang bermakna secara signifikan juga diperoleh pada kadar GFAP serum dengan mRS 30 hari (p=0,009; RO=1,603).Diskusi: Kadar GFAP serum yang diambil <72 jam pertama onset stroke hemoragik berhubungan dengan luaran klinis neurologis pasien stroke hemoragik.Kata kunci: Glial fibrillary acidic protein, modified Rankin Scale, National Institute of Health Stroke Scale, stroke hemoragik

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Hemorrhagic Stroke

Cited by 8 publications

References 0 publications

Pengembangan dan Validasi Skor Luaran Disabilitas Pasien Perdarahan Intraserebral di RS Bethesda Yogyakarta

Pengembangan dan Validasi Skor Luaran Disabilitas Pasien Perdarahan Intraserebral di RS Bethesda Yogyakarta

Task-driven optimization of the non-spectral mode of photon counting CT for intracranial hemorrhage assessment

Hubungan Kadar Glial Fibrillary Acidic Protein (Gfap) Serum Dengan Luaran Klinis Neurologis Pasien Stroke Hemoragik

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