Hemorrhoid Therapy with Medicinal Plants: Astringency and Inhibition of Lipid Peroxidation as Key Factors

Odukoya, Onatolu; Sofidiya, Margaret O.; Ilori, O. O.; Gbededo, M. O.; Ajadotuigwe, J. O.; Olaleye, O. O.

doi:10.3923/ijbc.2009.111.118

Cited by 9 publications

(9 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…3 , 4 , 5 , 6 , 7 , 8 Its uses as an astringent and for the treatment of acne and irritable scalp conditions have also been documented. 9 , 10 , 11 , 12 Antiviral activities have also been reported. 13 , 14 However, there is scant scientific evidence on the antibacterial effects of WH extracts.…”

Section: Introductionmentioning

confidence: 95%

An assessment of the growth inhibition profiles of Hamamelis virginiana L. extracts against Streptococcus and Staphylococcus spp.

Cheesman

Alcorn

Verma

et al. 2021

Journal of Traditional and Complementary Medicine

View full text Add to dashboard Cite

Staphylococcal and streptococcal species trigger a wide variety of infections involving epithelial tissues. Virginian witch hazel (WH; Hamamelis virginiana L.; family: Hamamelidaceae) is a plant that has been used traditionally by Native Americans to treat a variety of skin conditions. Extracts from the leaves were examined for their inhibitory effects on these bacterial species. Solvents of different polarity (water, methanol, ethyl acetate, hexane and chloroform) were used to prepare extracts from WH leaves, and the aqueous resuspensions were screened for antibacterial activities using disc diffusion and liquid dilution assays. Extract phytochemical profiles and toxicities were also examined, and combinations of extracts with conventional antibiotics were tested against each bacterial strain. The methanolic and aqueous extracts inhibited the growth of S. oralis , S. pyogenes , S. epidermidis and S. aureus , but not S. mutans . The extracts were especially active against staphylococcal species, with MIC values between 200 and 500 μg/ml. Combinations of active extracts with conventional antibiotics failed to yield beneficial interactions, except for two cases where additive interactions were observed (aqueous WH extract combined with chloramphenicol against S. oralis , and methanolic WH extract combined with ciprofloxacin against S. aureus ). Phytochemical assays indicated an abundance of tannins, triterpenoids and phenolics in the water and methanol extracts, with trace amounts of these components in the ethyl acetate extract. Phytochemicals were not detected in hexane and chloroform extracts. Thus, phytochemical abundance in extracts was concordant with antibacterial activities. All extracts were found to be non-toxic in Artemia nauplii assays. These findings indicate the potential for WH leaf extracts for clinical use in treating staphylococcal and streptococcal infections, while substantiating their traditional Native American uses.

show abstract

Section: Introductionmentioning

confidence: 95%

An assessment of the growth inhibition profiles of Hamamelis virginiana L. extracts against Streptococcus and Staphylococcus spp.

Cheesman

Alcorn

Verma

et al. 2021

Journal of Traditional and Complementary Medicine

View full text Add to dashboard Cite

show abstract

“…A growing body of research focusing on individual tannins found in many of these medicinal plants are providing scientific evidence of medicinal benefits. 31,33,38,[41][42][43][44][45][46][47][48][82][83][84][85][86][87] Current research into the applications of TA have found that it possesses several medicinal qualities, such as antibacterial, antioxidant and anticancer activity. 22,[88][89][90][91][92][93][94][95][96][97][98] It has also been suggested that TA may have antiviral and antifungal properties as well.…”

Section: Tannic Acid In Traditional and Modern Medicinesmentioning

confidence: 99%

“…[26][27][28][29][30][31][32][33][34]43 TA and similar tannins have been used in traditional medicines to treat a variety of maladies, such as burns, bowel issues involving diarrhea and hemorrhoids, as an anti-inflammatory, and to prevent tooth decay. 31,33,38,41,[44][45][46][47][48] The many historical applications of tannic acid demonstrate its unique properties and chemistry that today can be utilized in the development of medicine and biomaterials.…”

Section: Introductionmentioning

confidence: 99%

Biomedical applications of tannic acid

2022

View full text Add to dashboard Cite

Tannic Acid (TA) is a naturally occurring antioxidant polyphenol that has gained popularity over the past decade in the field of biomedical research for its unique biochemical properties. Tannic acid, typically extracted from oak tree galls, has been used in many important historical applications. TA is a key component in vegetable tanning of leather, iron gall ink, red wines, and as a traditional medicine to treat a variety of maladies. The basis of TA utility is derived from its many hydroxyl groups and its affinity for forming hydrogen bonds with proteins and other biomolecules. Today, the study of TA has led to the development of many new pharmaceutical and biomedical applications. TA has been shown to reduce inflammation as an antioxidant, act as an antibiotic in common pathogenic bacterium, and induce apoptosis in several cancer types. TA has also displayed antiviral and antifungal activity. At certain concentrations, TA can be used to treat gastrointestinal disorders such as hemorrhoids and diarrhea, severe burns, and protect against neurodegenerative diseases. TA has also been utilized in biomaterials research as a natural crosslinking agent to improve mechanical properties of natural and synthetic hydrogels and polymers, while also imparting anti-inflammatory, antibacterial, and anticancer activity to the materials. TA has also been used to develop thin film coatings and nanoparticles for drug delivery. In all, TA is fascinating molecule with a wide variety of potential uses in pharmaceuticals, biomaterials applications, and drug delivery strategies.

show abstract

“…A substantial increase in free radical scavenging activity of the final prepared formulation compared with the decoction was observed (Table 4), which may be due to chemical changes occurring during fermentation, and the constituents introduced through addition of prakshepa dravyas and jaggery, as discussed earlier [2]. Inhibition of free radicals generated in anorectal diseases (for which Abhayarishta is commonly used) decreases inflammation, pain, itching and promotes vein elasticity in the perianal area [12].…”

Section: Antioxidant Activitymentioning

confidence: 85%

Chemical Changes during Fermentation of Abhayarishta and its Standardization by HPLC-DAD

Lal

Tripathi

Jachak

et al. 2010

Natural Product Communications

View full text Add to dashboard Cite

Abhayarishta is an Ayurvedic formulation prepared traditionally by the fermentation of the decoction of Terminalia chebula (pericarp), Vitis vinifera (fruits), Embelia ribes (fruits) and Madhuca indica (flowers). In the present communication, chemical changes occurring during fermentation in Abhayarishta have been studied for the purpose of its standardization. An HPLC-DAD method for quantitative estimation of selected marker constituents in the formulation has been developed and validated. A comparison of decoction and final processed formulation revealed that major polyphenolics (chebulagic and chebulinic acid) of T. chebula were hydrolyzed to their respective monomers and, consequently, there was an increase in the amount of chebulic acid, gallic acid, ellagic acid and ethyl gallate after fermentation. 5-Hydroxymethyl furfural (5-HMF) was also found in the formulation. Thus, emphasis is laid upon consideration of processing methods of formulation which has been lacking in the standardization of most of Ayurvedic formulations.

show abstract

Hemorrhoid Therapy with Medicinal Plants: Astringency and Inhibition of Lipid Peroxidation as Key Factors

Cited by 9 publications

References 17 publications

An assessment of the growth inhibition profiles of Hamamelis virginiana L. extracts against Streptococcus and Staphylococcus spp.

An assessment of the growth inhibition profiles of Hamamelis virginiana L. extracts against Streptococcus and Staphylococcus spp.

Biomedical applications of tannic acid

Chemical Changes during Fermentation of Abhayarishta and its Standardization by HPLC-DAD

Contact Info

Product

Resources

About