Hemostasis and Coagulation

Levi, Marcel; Poll, Tom van der

doi:10.1007/978-0-387-68113-9_8

Cited by 4 publications

(2 citation statements)

References 82 publications

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“…Coagulation is initiated in in ammatory settings, and endogenous anticoagulant processes are reduced, along with the brinolytic system. In ammatory cytokines can act as main mediators in coagulation activation [15][16][17]. Thrombin mediates its cellular effects through proteolytic activation of protease-activated receptors (PARs).…”

Section: Introductionmentioning

confidence: 99%

LPS Induced Coagulation and Neuronal Damage in a Mice Model is Attenuated by Enoxaparin

Berkowitz

Gofrit

Aharoni

et al. 2022

Preprint

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Neuroinflammation and coagulation interact, therefore, the neural effects of lipopolysaccharide (LPS)-induced inflammation (1 mg/kg, intraperitoneal (IP), n = 20) and enoxaparin treatment (1 mg/kg, IP, 15 minutes, and 12 hours following LPS, n = 20) were studied in C57BL/6J mice. One week after LPS injection, sensory, motor, and cognitive functions were assessed by a hot plate, rotarod, Open-Field test (OFT), and Y-maze. We measured thrombin activity with a fluorometric assay, hippocampal mRNA expression of coagulation and inflammation factors by real-time- PCR and serum neurofilament-light-chain (NfL), and tumor necrosis factor-α (TNF-α) by a single-molecule array (Simoa) assay. Reduced crossing center frequency was observed in both LPS groups in the OFT (p = 0.02) along with a minor motor deficit between controls and LPS indicated by the rotarod (p = 0.057). Increased hippocampal thrombin activity (p = 0.038), and protease-activated receptor 1 (PAR1) mRNA (p = 0.01) were measured in LPS compared to controls but not in enoxaparin LPS treated mice (p = 0.4, p = 0.9, respectively). Serum NfL and TNF-α levels were elevated in LPS mice (p < 0.05) and normalized by enoxaparin treatment. These results indicate that inflammation, coagulation, neuronal structure, and function are linked and may regulate each other, suggesting another pharmacological mechanism for intervention in neuroinflammation.

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Section: Introductionmentioning

confidence: 99%

LPS Induced Coagulation and Neuronal Damage in a Mice Model is Attenuated by Enoxaparin

Berkowitz

Gofrit

Aharoni

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…Evidências demonstram uma interação cruzada entre inflamação e coagulação, com a inflamação induzindo a ativação da coagulação e a coagulação acentuando a atividade inflamatória (Figura 1). [29][30][31][32] As plaquetas têm um papel central no desenvolvimento das anormalidades da coagulação na sepse e podem ser ativadas diretamente por mediadores pró-inflamatórios, como o fator ativador de plaquetas, bem como por meio da trombina gerada. A ativação de plaquetas também pode estimular a formação de fibrina por mecanismo alternativo.…”

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COVID-19 e Estado de Hipercoagulabilidade: Uma Nova Perspectiva Terapêutica

Nascimento¹,

Gomes²,

Júnior³

et al. 2020

Arquivos Brasileiros De Cardiologia

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How Hemostatic Agents Interact With the Coagulation Cascade

Overbey¹,

Jones²,

Robinson³

2014

AORN Journal

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Hemostasis is a critical component of the preservation of hemodynamic stability and operative visibility during surgery. Initially, hemostasis is achieved via the careful application of direct pressure to allow time for the coagulation cascade to create a fibrin and platelet plug. Other first-line methods of hemostasis in surgery include repair or ligation of the bleeding vessel with sutures, clips, or staples and coagulation of the bleeding site with a thermal energy-based device. When these methods are insufficient to provide adequate hemostasis, topical hemostatic agents can be used to augment the creation of a clot during surgery. A basic understanding of how and where these products interact with the coagulation cascade is essential to achieving optimal hemostasis outcomes.

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Hemostasis and Coagulation

Cited by 4 publications

References 82 publications

LPS Induced Coagulation and Neuronal Damage in a Mice Model is Attenuated by Enoxaparin

LPS Induced Coagulation and Neuronal Damage in a Mice Model is Attenuated by Enoxaparin

COVID-19 e Estado de Hipercoagulabilidade: Uma Nova Perspectiva Terapêutica

How Hemostatic Agents Interact With the Coagulation Cascade

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