Hemostasis and Fibrinolysis Factors in First-Degree Relatives of Patients with Type 2 Diabetes without Hypertension

Trifiletti, A; Lasco, Antonino; Scamardi, R; Cincotta, M.; Gaudio, Agostino; Barbera, N; Frisina, N

doi:10.1159/000065214

Cited by 6 publications

(3 citation statements)

References 15 publications

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“…Increased plasma D-dimer levels not only can predict a range of adverse health outcomes in the general population ( 11 , 34 ) but also can partly account for metabolic diseases and vascular complications with a background of insulin resistance. When compared to the healthy controls, the level of plasma D-dimer was obviously elevated in the first-degree relatives of T2D ( 35 ), prediabetes ( 18 ), gestational hypertension ( 36 ), polycystic ovary syndrome ( 37 ), and metabolic syndrome ( 38 ), let alone in overt T2D. Moreover, plasma D-dimer was observed to be independently associated with inflammatory cytokines ( 39 ), oxidized LDL ( 40 ), poor glycemic control (hyperglycemia, glycemic variability, and hypoglycemia) ( 41 – 43 ), diabetic retinopathy and nephropathy ( 14 , 15 ), and CVD ( 17 ) in patients with T2D.…”

Section: Discussionmentioning

confidence: 97%

Increased plasma D-dimer levels may be a promising indicator for diabetic peripheral neuropathy in type 2 diabetes

Zhuang

et al. 2022

Front. Endocrinol.

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BackgroundIncreased plasma D-dimer levels have been reported to be associated with a range of adverse health outcomes. This study aimed to determine whether plasma D-dimer is connected to diabetic peripheral neuropathy (DPN) in patients with type 2 diabetes (T2D).MethodsThis study was part of a series exploring the potential risks for DPN. All patients were questioned for neurologic symptoms, examined for neurologic signs, and received nerve conduction studies to collect nerve action potential onset latency, amplitude, and nerve conduction velocity (NCV). Composite Z scores of latency, amplitude, and NCV were calculated. DPN was confirmed as both at least a neurologic symptom/sign and an abnormality of nerve conduction studies. Coagulation function indices, such as plasma D-dimer levels, were also synchronously detected.ResultsWe finally recruited 393 eligible patients for this study, of whom 24.7% (n = 97) were determined to have DPN. The plasma D-dimer level was found to be closely associated with the composite Z score of latency, amplitude, and NCV after adjusting for other coagulation function indices and clinical covariates (latency: β = 0.134, t = 2.299, p = 0.022; amplitude: β = –0.138, t = –2.286, p = 0.023; NCV: β = –0.139, t = –2.433, p = 0.016). Moreover, the prevalence of DPN in the first, second, third, and fourth quartiles (Q1, Q2, Q3, and Q4) of the D-dimer level was 15.2%, 15.9%, 26.4%, and 42.7%, respectively (p for trend < 0.001). The corresponding adjusted odds ratios and 95% CIs for DPN in D-dimer quartiles were 1, 0.79 (0.21–2.99), 1.75 (0.49–6.26), and 5.17 (1.38–19.42), respectively. Furthermore, the optimal cutoff value of the plasma D-dimer level to discriminate DPN was ≥0.22 mg/L (sensitivity = 67.01%, specificity = 58.78%, and Youden index = 0.26) after analysis by the receiver operating characteristic curve.ConclusionsIncreased plasma D-dimer levels may be a promising indicator for DPN in patients with T2D.

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Section: Discussionmentioning

confidence: 97%

Increased plasma D-dimer levels may be a promising indicator for diabetic peripheral neuropathy in type 2 diabetes

Zhuang

et al. 2022

Front. Endocrinol.

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“…D-dimers are small protein fragments produced during fibrinolysis and are well-established markers of venous thrombosis formation in the general population [ 42 ]. Previous studies indicated that increased D-dimer concentration was found in individuals with prediabetes [ 43 ], type 2 diabetes patients [ 42 ], or even first-degree relatives of type 2 diabetes patients [ 44 ]. Cheng et al [ 45 ] showed that patients with type 2 diabetes who have high plasma concentrations of D-dimer are at an increased risk of cardiovascular disease events, even after adjusting for cardiovascular risk factors and treatments.…”

Section: Discussionmentioning

confidence: 99%

Associations Between Mean Platelet Volume and Various Factors in Type 2 Diabetes Patients: A Single-Center Study from Poland

Gacuta,

Koper-Lenkiewicz,

Milewska

et al. 2023

Med Sci Monit

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Background Thromboembolic episodes, which are largely mediated by blood platelets, are prevalent chronic complications of diabetes. The mean platelet volume (MPV) serves as a marker for in vivo platelet activation. This study aimed to assess the factors influencing MPV in 106 patients with type 2 diabetes, compared with 59 non-diabetic individuals at a single center in Poland. Material/Methods We performed linear regression analysis, with MPV as the dependent variable and factors such as age, sex, thrombopoiesis-influencing cytokines, blood pressure, body mass index, glycosylated hemoglobin percentage, platelet count, large platelet count, lipid profile parameters, creatinine concentration, estimated glomerular filtration rate, treatment modalities, and comorbidities as independent variables. MPV was measured using the ADVIA 2120 hematology analyzer, with a reference range of 7–12 fL. Results The analysis revealed that in patients with type 2 diabetes, an increase in platelet count by 10×10 3 /μL resulted in a decrease in MPV by 0.05 ( P <0.001), while an increase in large platelet count by 1×10 3 /μL led to an increase in MPV by 0.18 ( P <0.001). Additionally, patients taking β-blockers or insulin had lower MPVs by 0.77 ( P= 0.008) and 5.63 ( P <0.001), respectively, compared with those not on these medications. Conclusions This study delineates the relationship between MPV, platelet parameters, and treatment modalities in type 2 diabetes, paving the way for further research to elucidate underlying mechanisms and potential clinical applications.

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“…However, alternative explanations are indispensable because the independent association between a family history of diabetes and increased IMT persisted after adjusting for HbA1c, total cholesterol, and triglyceride levels. This independent association could be related to endothelial dysfunction [ 30 ], impaired fibrinolysis [ 31 ], as yet unidentified genetic factors, inflammatory processes [ 14 ], or interactions or mediating effects not considered in our analysis. A previous study suggested that elevated fasting and postprandial glucose concentrations in the offspring of patients with type 2 diabetes could lead to the loss of endothelial function, resulting in increased IMT [ 15 ].…”

Section: Discussionmentioning

confidence: 99%

Association between a family history of diabetes and carotid artery atherosclerosis in Korean adults

et al. 2021

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OBJECTIVES Diabetes is a well-known risk factor for atherosclerosis, but the association between a family history of diabetes and atherosclerosis remains unknown. In this study, we assessed the association between a family history of diabetes and increased carotid intima-media thickness (IMT), a marker of subclinical atherosclerosis, in a middle-aged Korean population. METHODS This cross-sectional study included 3,974 community-dwelling adults (1,404 male and 2,570 female) aged 30-64 years from the Cardiovascular and Metabolic Diseases Etiology Research Center cohort. The presence of a family history of diabetes was assessed through face-to-face interviews using a standardized questionnaire. Carotid IMT was assessed using B-mode ultrasonography, and increased IMT was defined as a value in the top quartile of the IMT values of all participants. Multivariate logistic regression was used to evaluate independent associations between a family history of diabetes and increased IMT. RESULTS A family history of diabetes was significantly associated with increased carotid IMT (odds ratio, 1.23; 95% confidence interval, 1.03 to 1.48) after adjusting for sex; age; body mass index; systolic blood pressure; total cholesterol, triglyceride, and hemoglobin A1c levels; smoking; alcohol consumption; exercise; use of antidiabetic, antihypertensive, and antilipidemic drugs; and a family history of hypertension. The positive association remained significant after excluding participants with diabetes (odds ratio, 1.21; 95% confidence interval, 1.00 to 1.47). CONCLUSIONS A family history of diabetes was positively associated with increased carotid IMT, even in participants without diabetes. Therefore, information on a family history of diabetes may help identify individuals at high risk of atherosclerotic cardiovascular disease.

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Hemostasis and Fibrinolysis Factors in First-Degree Relatives of Patients with Type 2 Diabetes without Hypertension

Cited by 6 publications

References 15 publications

Increased plasma D-dimer levels may be a promising indicator for diabetic peripheral neuropathy in type 2 diabetes

Increased plasma D-dimer levels may be a promising indicator for diabetic peripheral neuropathy in type 2 diabetes

Associations Between Mean Platelet Volume and Various Factors in Type 2 Diabetes Patients: A Single-Center Study from Poland

Association between a family history of diabetes and carotid artery atherosclerosis in Korean adults

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