Hemostasis in Patients With Hematoma Retrochorial

Буштырева, И. О.; Кузнецова, Н.Б.; Caplina, A. A.; Kovaleva, Anastassiya; Dmitrieva, M. P.; Bordaeva, O. Y.; Kupryaeva, M. S.

doi:10.17749/2313-7347.2016.10.2.016-022

Cited by 2 publications

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“…Indicators of the hemostasis system in patients with normal pregnancy and those with retrochorial hematoma are presented in Table 2 . The values of PT, aPTT, TT, fibrinogen, SFMC, D-dimer, and activity and concentration of PG for healthy pregnant women were within the normal range ( Table 1 ) [ 21 , 22 , 23 ].…”

Section: Resultsmentioning

confidence: 99%

“…Often, the concentration of fibrinogen degradation products in the mother’s blood does not reflect the state of the fibrinolytic system and its main component, plasminogen. In a study on the assessment of hemostatic parameters in pregnant women with retrochorial hematoma, the authors showed that elevated levels of D-dimer and hypercoagulability may indicate the formation of retrochorial hematoma [ 22 ].…”

Section: Introductionmentioning

confidence: 99%

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Hemostasis System and Plasminogen Activity in Retrochorial Hematoma in the First Trimester of Pregnancy

Tikhonova

Kuznetsova

et al. 2022

Biomedicines

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(1) Background: The components of the fibrinolytic system and its main component, plasminogen, play a key role in the first months of pregnancy. The effect of autoantibodies interacting with plasminogen in the formation of retrochorial hematoma is unknown. The aim of our study was to determine the role of plasminogen and IgA, IgM, and IgG, which bind to plasminogen, in retrochorial hematoma. (2) Methods: Prothrombin time (PT), thrombin time (TT), partial activated thromboplastin time (aPTT), soluble fibrin-monomer complex (SFMC), D-dimer, plasminogen activity (%Plg), plasminogen concentration (Plg), and the levels of IgG (IgG-Plg), IgM (IgM-Plg), IgA (IgA-Plg) interacting with plasminogen were determined in plasma samples of 57 women with normal pregnancy and 16 with retrochorial hematoma. (3) Results: %Plg in plasma samples from women with retrochorial hematoma was significantly lower than in plasma samples from women with normal pregnancy. The diagnostic significance of %Plg in the ROC analysis was AUC = 0.85. A direct correlation was found between aPTT and the level of autologous IgM interacting with plasminogen. (4) Conclusions: A decrease in the activity of plasminogen in the blood serum of women in the first trimester of pregnancy may indicate disturbances in the hemostasis system and the formation of retrochorial hematoma. According to the results of the study, it is possible to recommend the determination of plasminogen activity in the management of pregnant women in gynecological practice.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Hemostasis System and Plasminogen Activity in Retrochorial Hematoma in the First Trimester of Pregnancy

Tikhonova

Kuznetsova

et al. 2022

Biomedicines

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Obstetric and perinatal aspects of retrochorial hematomas

Vdovychenko

Zhuk

Salnikov

2021

RHW

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The problem of pregnancy loss has medico-social, scientific and practical significance. Almost 85% of pregnancy loss occur in the I trimester of gestation (up to 13 weeks), and 15% – II and III trimesters. One of the causes of bleeding in the I trimester of gestation is retrochorial hematoma (RCH) – the accumulation of blood in the retrochorial space due to partial detachment of the chorionic plate from the adjacent of decidua in a genetically normal embryo. The article provides an analysis of scientific publications that highlight the obstetric and perinatal aspects of the characteristics of RCH, the etiological features of their occurrence and important points of the treatment to avoid the development of further complications, the preservation and prolongation of pregnancy. The features of diagnostics and subsequent therapy to provide early support for pregnancy and reduce the incidence of gestational complications are considered. Ultrasound examination of the uterus is of the great prognostic importance in the diagnosis of RCH, which can identify the threatening signs of pregnancy associated with preterm birth, development of fetal growth retardation, placental abruption in the ІІ and ІІІ trimesters, low fetal birth weight. The data of modern researches indicate that the diagnosis of RCH in the presence of a living genetically normal embryo, the appointment of pathogenetic therapy based on gestagenic and antifibrinolytic therapy is the key for the success of treatment of this perinatal pathology, a significantly decreasing the rate of pregnancy losses and an improvement in the quality of gestational process. Today, obstetricians and gynecologists have a deal with the task to find new preclinical signs to predict possible complications of pregnancy and develop effective algorithms for prevention and treatment, which will prolong pregnancy with RCH and achieve positive perinatal outcomes.

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Hemostasis in Patients With Hematoma Retrochorial

Cited by 2 publications

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Hemostasis System and Plasminogen Activity in Retrochorial Hematoma in the First Trimester of Pregnancy

Hemostasis System and Plasminogen Activity in Retrochorial Hematoma in the First Trimester of Pregnancy

Obstetric and perinatal aspects of retrochorial hematomas

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