Hemostatic and Hepatoprotective Bioactivity of Junci Medulla Carbonisata-Derived Carbon Dots

Abstract

Aim: To explore the hemostatic and hepatoprotective bioactivity of Junci Medulla Carbonisata-derived Carbon Dots (JMC-CDs). Materials & methods: The JMC-CDs were characterized using transmission electron microscopy, HPLC, Fourier transform IR, UV, fluorescence and x-ray photoelectron spectroscopy. The hemostatic effect of JMC-CDs was evaluated and confirmed by trauma hemorrhagic animal models and internal hemorrhage animal model induced by Deinagkistrodon acutus venom. Results: The JMC-CDs ranged in diameter from 1.0 to 8 nm and had a yield of 0.12%. Moreover, JMC-CDs not only possessed remarkable hemostatic efficacy but could also prevent hemorrhage-induced liver injury, as demonstrated by the reduced serum levels of biochemical indicators of liver damage such as aspartate aminotransferase, alanine amino transferase, alkaline phosphatase, total bilirubin and direct bilirubin. Conclusion: The JMC-CDs may have great potentials in clinical practice.

Haemostatic Nanoparticles-Derived Bioactivity of from Selaginella tamariscina Carbonisata

“…A range of applications has been developed for emerging nanomaterials including drug delivery [26], biological imaging [27], and optical catalysts [28]. NPs have been reported in other TCMs carbonised at high temperature including Pollen Typhae Carbonisata, Cirsium Setosum Carbonisata, Schizonepetae Herba Carbonisata, and Junci Medulla Carbonisata [5,[29][30][31]. The STC-NPs possessed components similar to those of other widely-studied nanoparticles [32,33].…”

Novel Carbon Dots Derived from Puerariae lobatae Radix and Their Anti-Gout Effects

“…Due to these properties, CDs have applications in biomedical fields, such as drug delivery [4], fluorescent probes for clinical diagnosis [5], bioimaging [6], therapy [7,8], and artificial mimicking enzymes [9]. Recently, more and more intrinsic bioactivities of CDs have been explored and reported, such as homeostatic bioactivity [10,11,12], wound-healing activity [13], hypoglycemic bioactivity [14], hepatoprotective bioactivity [15], radical-scavenging activity [16], peroxidase-like activity [17], anticancer activity [7,18], and antibacterial activity [19,20]. However, as one of the most important nanomaterials, volumes of the studies concerned with CDs’ bioactivities are still small, and the functions of CDs have yet to be fully developed.…”

<p>Carbon Dots from <em>Paeoniae Radix Alba</em> Carbonisata: Hepatoprotective Effect</p>

“…CDs have been reported in other charcoal drugs prepared at a high temperature, including Junci Medulla Carbonisata, Pollen Typhae Carbonisata and Phellodendri Cortex Carbonisata. 10,32,33 The size and morphology of PRAC-CDs were examined by employing the TEM technique and are similar to those previously reported for carbon dots. 34 The XPS and FTIR results show that the structure of PRAC-CDs comprises multiple functional groups, including carbonyl, carboxyl, and hydroxyl groups, and that the photoluminescence of CDs can be attributed to the multiphoton activation of various oxygen-containing functional groups.…”