Hemostatic and inflammatory markers in obese youths: Effects of exercise and adiposity

Barbeau, Paule; Litaker, Mark S.; Woods, Kristy F.; Lemmon, Christian R.; Humphries, Matthew C.; Owens, Scott; Gutin, Bernard

doi:10.1067/mpd.2002.127497

Cited by 97 publications

(93 citation statements)

References 28 publications

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“…Concerning PAI-1 activity & antigen and tPA activity & tPA antigen our results showed that weight loss significantly increase the values of tPA antigen and tPA activity and reduce the values of PAI-1 activity and antigen, these findings are in line with many previous trials of weight loss (20)(21)(22). In addition, Murakami and colleagues stated that increased values of PAI-1 activity positively correlated with high values of BMI in obese subjects, which reduced as a result to weight loss [13].…”

Section: Discussionsupporting

confidence: 81%

“…We found that weight loss program improves the parameters of systemic inflammation along with amelioration of coagulation disorders in obese subjects, our findings were in line with many previous studies. Barbeau and colleagues stated that weight loss could reduce the cardiovascular disorders (CVD) mortality rate via modulation of endothelial and fibrinolytic dysfunction (20). Svendsen and colleagues proved that weight reduction could control oxidative stress, platelets activation and chronic inflammation in obese women (21).…”

Section: Discussionmentioning

confidence: 99%

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Coagulation, fibrinolytic and cytokines parameters response to weight reduction in obese subjects

El-Kader

Al-Jiffri

2018

Electron J Gen Med

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Background: Obesity is a major risk factor for developing cardiovascular disorders due to increased platelets count and platelets activation. Objective: The aim of this study was to measure the influence of weight loss on the coagulation and fibrinolysis parameters among obese patients. Material and Methods: One hundred obese subjects of both genders (mean age 46.72± 3.13 year) selected from the Internal Medicine Department at King Abdul Aziz University Teaching Hospital, their body mass index (BMI) ranged from 32 to 36 Kg/m 2 . Participants enrolled randomly into two study groups; the first group (A) received aerobic exercises and diet regimen for three months, while the second group (B) received no exercise training or diet regimen for three months. Results: Mean values of von Willbrand factor antigen (vWF-Ag), fibrinogen, plasminogen activator inhibitor-1 antigen (PAI-1:Ag) and plasminogen activator inhibitor-1 activity (PAI-1:Ac), tumor necrotic factor-alpha (TNF-α), Interleukin -6 (IL-6) and body mass index (BMI), while the mean values of partial thromboplastin time (PTT), prothrombin time (PT), tissue plasminogen activator antigen (tPA:Ag) and tissue plasminogen activator activity (tPA:Ac) increased significantly after 3 months in group (A) as a result of weight reduction program. However, the mean values of all investigated parameters of group (B) had no significant changes. Moreover, comparison between both groups had statistical significant differences in all investigated parameters at the end of the study (P<.05). Conclusion: weight reduction program modulates systemic inflammation, fibrinolytic and coagulation of obese subjects.

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Section: Discussionsupporting

confidence: 81%

Section: Discussionmentioning

confidence: 99%

Coagulation, fibrinolytic and cytokines parameters response to weight reduction in obese subjects

El-Kader

Al-Jiffri

2018

Electron J Gen Med

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“…Hispanic children (10,30) and South Asian children (7) have greater CRP levels than white children of similar BMI or adiposity. Although 50 black youth had higher mean levels of CRP than 24 white youth of similar percent body fat, the difference was not statistically significant (31). In the current cohort after adjustment for body size, black youth were shown to have higher CRP levels than white youth.…”

Section: Resultsmentioning

confidence: 70%

Relation of C-Reactive Protein to Insulin Resistance and Cardiovascular Risk Factors in Youth

et al. 2005

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OBJECTIVE -Insulin resistance and C-reactive protein (CRP) levels are strongly correlated in adults. This study explored the relationship in youth.RESEARCH DESIGN AND METHODS -Associations between CRP levels, cardiovascular risk, and insulin resistance measured by the euglycemic clamp were investigated in 342 healthy Minneapolis youth.RESULTS -There was no difference in mean CRP levels among boys (n ϭ 189, CRP 1.10 Ϯ 0.46 mg/l) and girls (n ϭ 153, CRP 1.16 Ϯ 0.63 mg/l; P ϭ 0.32). There was also no difference between CRP and Tanner stage. CRP, adjusted for BMI, was significantly greater in black subjects compared with white subjects (P ϭ 0.03). CRP was strongly related to adiposity in both girls and boys. CRP levels were related to fasting insulin levels (r ϭ 0.16, P ϭ 0.003) but this association was not significant after adjustment for BMI (r ϭ 0.07, P ϭ 0.21). Similarly, M, the euglycemic clamp measurement of insulin sensitivity, was significantly related to CRP levels (r ϭ Ϫ0.13, P ϭ 0.02) but not when M was normalized to lean body mass (M lbm ) (r ϭ Ϫ0.10, P ϭ 0.09). There was a significant inverse correlation between M lbm and CRP quartiles, which disappeared after adjustment for BMI. There was no significant association between CRP levels and lipids, blood pressure, physical activity, or left ventricular mass.CONCLUSIONS -In contrast to adult subjects, after adjustment for adiposity, CRP levels in children age 10 -16 years were not significantly associated with insulin resistance or with other factors comprising the metabolic syndrome. This is consistent with the concept that insulin resistance may precede the development of CRP elevation in the evolution of the metabolic syndrome. Diabetes Care 28:1763-1768, 2005C -reactive protein (CRP) is an acutephase reactant usually associated with serious infection and inflammation. More recently, it has become clear that subtle elevation of CRP levels within the "normal" adult range is an indicator of subclinical disease, such as that related to 1) the risk of cardiovascular disease in healthy men and women and in individuals with type 1 diabetes (1), 2) the risk factors associated with the metabolic syndrome (1-3), and 3) the onset of type 2 diabetes (4). The mechanisms accounting for these relations are not well understood.Insulin resistance and CRP levels are strongly correlated in adults (2,3,5,6). Although CRP is known to be associated with adiposity in youth (7-12), there are no data relating it to insulin resistance in children or adolescents. These data may be important because the insulin resistance syndrome has its origins in youth (13-15) and the independent roles of insulin resistance and adiposity in establishment of the syndrome (and in ongoing development from childhood into adulthood) have not been defined. If inflammation is a precursor to cardiovascular disease, determining these early relations would be highly relevant to the design of further investigation and prevention strategies. As recently suggested (16), this developmental period might be p...

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“…The inverse association between physical activity and IL-6 in the present study population indicates that such a beneficial relationship is observed as early as in adolescence. At variance with most studies, of which two were on children [7,9], there was no association between physical activity and CRP levels. Other recent observational studies in adults could not demonstrate a significant independent association between physical activity and CRP [33,34].…”

Section: Discussionmentioning

confidence: 66%

“…Two studies have examined the influence of physical activity on CRP in youths. While an inverse association between regular physical activity and CRP was observed in one [7], the other failed to show any effect of an 8-month physical training programme in obese adolescents [9]. The relationship of physical activity with IL-6 has never been studied in youths.…”

Section: Introductionmentioning

confidence: 94%

Relationships of physical activity with metabolic syndrome features and low-grade inflammation in adolescents

Platat

Wagner

Klumpp³

et al. 2006

Diabetologia

103

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Aims/hypothesis Physical activity has beneficial effects on symptoms of the metabolic syndrome and low-grade inflammation in adults. These associations have rarely been studied in adolescents. Moreover, it has not been established whether they depend on adiposity, fat localisation and adipokines. Subjects, materials and methods We used cross-sectional data of 640 12-year-old adolescents participating in the Intervention Centred on Adolescents' Physical Activity and Sedentary Behaviour Study (ICAPS). Weight, height, body fat mass and WHR were measured. Metabolic syndrome components, two inflammatory markers (IL-6 and Creactive protein), plasma leptin, adiponectin and soluble TNF-α receptor 1 (sTNF-α R1) were determined. Insulin resistance was estimated by homeostasis model assessment (HOMA) and energy expenditure due to organised leisuretime physical activity (PAE) assessed by questionnaire. Results The metabolic syndrome was present in 5.8% of the adolescents. After adjustment for sex, sexual maturity and socio-economic status, a beneficial relationship between PAE and all metabolic syndrome features was found, but only the associations with HOMA and IL-6 were independent of body fat mass and WHR. Adjusted means from the lowest to the highest tertile of PAE were 1.99, 1.80 and 1.78 for HOMA (p=0.04), and 0.88, 0.69 and 0.70 pg/ml for IL-6 (p=0.02). PAE was inversely associated with leptin, independently of body fat mass and WHR (p<10 −2 ), but not with adiponectin or sTNF-α R1. Further adjustment for adipokines did not change the relationships of PAE with HOMA and IL-6. Conclusions/interpretation In adolescents, physical activity is inversely related to HOMA and IL-6, independently of adiposity and fat localisation. These relationships are not accounted for by adipokines.

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Hemostatic and inflammatory markers in obese youths: Effects of exercise and adiposity

Cited by 97 publications

References 28 publications

Coagulation, fibrinolytic and cytokines parameters response to weight reduction in obese subjects

Coagulation, fibrinolytic and cytokines parameters response to weight reduction in obese subjects

Relation of C-Reactive Protein to Insulin Resistance and Cardiovascular Risk Factors in Youth

Relationships of physical activity with metabolic syndrome features and low-grade inflammation in adolescents

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