Hemostatic and Nonhemostatic Effects of Heparan Sulfate Proteoglycans

Nadir, Yona; Lisman, Ton

doi:10.1055/s-0041-1724119

Cited by 4 publications

(7 citation statements)

References 9 publications

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Section: Therapeutic Effects Of Fucoidan On Atherosclerosismentioning

confidence: 99%

“…It is speculated that negatively charged fucoidan binds and inactivates cationic proteins, activating the complement system and histamine and thus increasing the stability of vascular endothelial cell membranes. 65 High blood pressure, smoking, an unhealthy diet, heavy drinking, metabolic syndrome, and other factors also induce the production of inflammatory factors. 66 Pro-inflammatory cytokines and adhesion molecules are markers of systemic inflammation and play an important role in endothelial dysfunction and the development of AS.…”

Section: Therapeutic Effects Of Fucoidan On Atherosclerosismentioning

confidence: 99%

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Application of fucoidan as treatment for cardiovascular and cerebrovascular diseases

Wang

Xu²,

Wei

et al. 2022

Therapeutic Advances in Chronic Disease

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Fucoidan is a marine polysaccharide. In recent years, fucoidan has attracted wide-scale attention from the pharmaceutical industries due to its diverse biological activities such as lipid-lowering, anti-atherosclerosis, and anticoagulation. This review clarifies the pharmacological effects of fucoidan in the treatment of human cardiovascular and cerebrovascular diseases. Fucoidan exerts a hypolipidemic effect by increasing the reverse transport of cholesterol, inhibiting lipid synthesis, reducing lipid accumulation, and increasing lipid metabolism. Inflammation, anti-oxidation, and so on have a regulatory effect in the process of atherosclerosis endothelial cells, macrophages, smooth muscle cells, and so on; fucoidan can not only prevent thrombosis through anticoagulation and regulate platelet activation, but also promote the dissolution of formed thrombi. Fucoidan has a neuroprotective effect, and also has a positive effect on the prognosis of the cardiovascular and cerebrovascular. The prospects of applying fucoidan in cardio-cerebrovascular diseases are reviewed to provide some theoretical bases and inspirations for its full-scale development and utilization.

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Section: Therapeutic Effects Of Fucoidan On Atherosclerosismentioning

confidence: 99%

Section: Therapeutic Effects Of Fucoidan On Atherosclerosismentioning

confidence: 99%

Application of fucoidan as treatment for cardiovascular and cerebrovascular diseases

Wang

Xu²,

Wei

et al. 2022

Therapeutic Advances in Chronic Disease

View full text Add to dashboard Cite

show abstract

“…Some examples over recent years are shown in Table 2 . 17 18 19 20 21 22 23 24 25 26 Of course, since online activity has overtaken print usage, the collation of highly specific themes perhaps becomes less imperative, and so STH now also collates issues with broader themes around thrombosis, 27 28 29 and laboratory diagnostics and bleeding, 30 31 32 33 34 35 as well as material related to COVID-19 (coronavirus disease 2019). 36 37 38…”

Section: Tablementioning

confidence: 99%

“…Another point of difference is that STH has in the past tended to solely publish "themed" issues, with each issue being related to a separate topic within the field of thrombosis and hemostasis. Some examples over recent years are shown in ►Table 2 [17][18][19][20][21][22][24][25][26]…”

mentioning

confidence: 99%