Hemostatic Coagulation Management in Trauma

Abstract

Trauma is still a leading cause of death in the 21st Century mainly due to uncontrolled hemorrhage. Trauma has also an increasing cost of treatment in patients. Recently we have been aware of the importance of complex hemostatic and immunoinflammatory responses in pathogenesis of "Trauma Induced Coagulopathy". As a result of understanding of changes on coagulation pathway in trauma, different hypotheses put forward explaining the trauma induced coagulopathy. New treatment algorithms also take place in early coagulation management of patients with traumatic coagulopathy. In this review, we aimed to explain pathophysiological determinant of trauma induced coagulopathy and recent evidence-based hemostatic treatment approach for patients with trauma.

The effects of hydroxyethyl starch and gelatine on lung tissue and coagulation during the resuscitation of rats with traumatic haemorrhagic shock

“…It has been stated that there is still debate about how optimal fluid therapy should be performed and which fluid type might be advantageous in patients with lung injuries requiring thoracic surgery [ 5 ]. Trauma-related coagulopathy is a condition in which complex haemostatic and immunoinflammatory responses cause abnormal clot formation and activation of anticoagulant pathways rather than procoagulants [ 6 ]. Bedside viscoelastic coagulation tests provide information on clot dynamics and quality [ 7 ].…”