Hemostatic kaolin-polyurethane foam composites for multifunctional wound dressing applications

Lundin, Jeffrey G.; McGann, Christopher L.; Daniels, Grant C.; Streifel, Benjamin C.; Wynne, James H.

doi:10.1016/j.msec.2017.05.084

Cited by 77 publications

(33 citation statements)

References 41 publications

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“…Polymeric dressings can be modified and functionalized to display interesting behaviors such as drug release and hemostatic characteristics [127,128]. Of these, multifunctional hemostatic kaolin–polyurethane (PU) foam composites were synthesized by Lundin et al [129] by incorporating kaolin into mechanically robust PU foam through a one-step preparation. The initial drug release rate and mechanical characteristics were controlled by the kaolin content.…”

Section: Biomedical Applications Of Polymer Compositesmentioning

confidence: 99%

Recent Overviews in Functional Polymer Composites for Biomedical Applications

2018

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Composite materials are considered as an essential part of our daily life due to their outstanding properties and diverse applications. Polymer composites are a widespread class of composites, characterized by low cost, facile processing methods, and varied applications ranging from daily-use issues to highly complicated electronics and advanced medical combinations. In this review, we focus on the most important fabrication techniques for bioapplied polymer composites such as electrospinning, melt-extrusion, solution mixing, and latex technology, as well as in situ methods. Additionally, significant and recent advances in biomedical applications are spotlighted, such as tissue engineering (including bone, blood vessels, oral tissues, and skin), dental resin-based composites, and wound dressing.

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Section: Biomedical Applications Of Polymer Compositesmentioning

confidence: 99%

Recent Overviews in Functional Polymer Composites for Biomedical Applications

2018

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“…Therefore, the drug can be loaded into the bers to achieve the purpose of reducing the toxic side effects and repeated administration of the excessive drug to the human body. [12][13][14] Among all different types of synthetic polymers, poly(lactic acid) (PLA) has been widely used in recent years because it is an environmentally benign material for potential application prospect as a substitute for medical dressings. 15 This is owed greatly to the polymer's favorable biocompatibility and to its safe degradation products.…”

Section: Introductionmentioning

confidence: 99%

Fabrication of centrifugally spun prepared poly(lactic acid)/gelatin/ciprofloxacin nanofibers for antimicrobial wound dressing

Xia

Liang

et al. 2019

RSC Adv.

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“…Hemostasis measurements were performed according to a procedure published in the literature, as follows:…”

Section: Methodsmentioning

confidence: 99%

Hemostatic and Absorbent PolyHIPE–Kaolin Composites for 3D Printable Wound Dressing Materials

Streifel

Lundin

Sanders

et al. 2018

Macromolecular Bioscience

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A novel hemostatic and absorbent wound dressing material compatible with 3D printing is developed to address deficiencies in current wound dressing protocol. The design involves an open celled, microporous hydrogel foam via a high internal phase emulsion (HIPE) template with biocompatible components and tunable hemostatic character by kaolin loading, the viscosity and cure kinetics of which are tailored for 3D printing applications. The use of nontoxic mineral oil organic phase results in cytocompatability with human dermal fibroblasts. Kaolin distribution is shown by X-ray diffraction and elemental dispersive spectroscopy to be exfoliated and dispersed in the hydrogel dressing. In addition to demonstrating high fluid absorption and noncytotoxicity of relevant cell lines, the high internal phase emulsion polymers (polyHIPEs) also match the hemostatic performance of commercial wound dressing materials. Furthermore, the polyHIPEs display the requisite rheological properties for 3D printing that result in the fabrication of a prototype dressing with hierarchical porosity and a large number of controllable form factors.

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Hemostatic kaolin-polyurethane foam composites for multifunctional wound dressing applications

Cited by 77 publications

References 41 publications

Recent Overviews in Functional Polymer Composites for Biomedical Applications

Recent Overviews in Functional Polymer Composites for Biomedical Applications

Fabrication of centrifugally spun prepared poly(lactic acid)/gelatin/ciprofloxacin nanofibers for antimicrobial wound dressing

Hemostatic and Absorbent PolyHIPE–Kaolin Composites for 3D Printable Wound Dressing Materials

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