Henoch-Schönlein purpura and Hodgkin’s disease

Ng, J. P.; Murphy, Joseph; Chalmers, E. M.; Hogg, R. B.; Cumming, R. L. C.; Peebles, Stokes

doi:10.1136/pgmj.64.757.881

Cited by 21 publications

(4 citation statements)

References 8 publications

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“…Five per cent of patients with vasculitis have a related malignancy, which may not be clinically obvious at presentation [1]. The most common form of vasculitis is a cutaneous leucocytoclastic vasculitis associated with haematological malignancy [2][3][4][5][6]. However, reports suggest that vasculitis involving the kidney may be linked to malignancy [4,[7][8][9][10][11].…”

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confidence: 99%

“…Renal carcinoma has been associated with Wegener's granulomatosis (WG) and may precipitate the onset of WG [10]. There are further case reports and a small series suggesting a link between malignancy and Henoch-Scho¨nlein purpura (HSP) [6,[12][13][14][15][16][17]. Most of these reports link HSP with solid organ tumours, but haematological malignancy has also been reported.…”

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confidence: 99%

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Malignancy is increased in ANCA-associated vasculitis

et al. 2004

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Malignancy is increased in ANCA-associated vasculitis

et al. 2004

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“…The association between IgAN and Hodgkin's disease has been previously described in only four adult patients. Ng et al [22] described a 39-year-old man who had typical symptoms of Henoch-Schönlein purpura (HSP), including abdominal pain, bloody diarrhea, arthralgia and purpura of both legs. The patient had proteinuria (1 g/day), and chest CT revealed a mass in the mediastinum.…”

Section: Urinary Proteome Analysismentioning

confidence: 99%

IgA nephropathy associated with Hodgkin’s disease in children: a case report, literature review and urinary proteome analysis

et al. 2007

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We report herein a rare case of IgAN associated with Hodgkin's disease in a 14-year-old boy. Clinical manifestations and laboratory parameters were improved after treatment with CHOP chemotherapy and enalapril. Urinary proteins were isolated and examined using state-of-the-art proteomic technology, before and during the treatment course. Two-dimensional gel electrophoresis showed obvious alterations in the urinary proteome profile in response to such therapy. Quantitative intensity analysis and gel mapping revealed 14 altered proteins with reduced excretion levels during the treatment course, including albumin, albumin complexed with decanoic acid, alpha-1 antitrypsin, cadherin-11 precursor, collagen alpha 1 (VI) chain precursor, complement C1q tumor necrosis factor-related protein, Ig heavy chain, Ig light chain, kininogen, inter-alpha-trypsin inhibitor (alpha-1 microglobulin), inter-alpha-trypsin inhibitor heavy chain, leucine-rich alpha-2 glycoprotein, beta-2 microglobulin, and transferrin precursor. Their potential roles in the pathogenesis and pathophysiology of IgAN are discussed.

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“…The descriptions of gastrointestinal (GI) involvement and renal involvement were added by Henoch in 1874 and 1899 (2). Although HSP has been recognized for over 100 years (3), the exact cause of HSP is presently unknown, but malignancy may be a causative factor (4–6). The present study reports a rare case of HSP associated with small cell lung cancer.…”

Section: Introductionmentioning

confidence: 99%

Adult Henoch-Schönlein purpura associated with small cell lung cancer: A case report and review of the literature

Zhang

Yang

et al. 2013

Oncology Letters

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The present study reports the case of a 53-year-old male who had been suffering from coughing and the presence of a blood-streaked sputum for >1 month. Chest computed tomography (CT) and a bronchoscopic brush smear were performed. The patient was subsequently diagnosed with small cell lung cancer (limited stage). The patient developed polyarthritis, abdominal pain, diarrhea and a purpuric rash at 14 days post thoracotomy surgery for lung cancer. Henoch-Schönlein purpura (HSP) was diagnosed based on the clinical symptoms. The patient received chemotherapy with steroid therapy, which resulted in complete remission of the HSP.

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Henoch-Schönlein purpura and Hodgkin’s disease

Abstract: Summary:A 39 year old man who presented with classical Henoch-Schonlein purpura wasshown to have mediastinal nodular sclerosing Hodgkin's lymphoma. The Henoch-Schonlein purpura resolved after treatment of the lymphoma.

Cited by 21 publications

References 8 publications

Malignancy is increased in ANCA-associated vasculitis

Malignancy is increased in ANCA-associated vasculitis

IgA nephropathy associated with Hodgkin’s disease in children: a case report, literature review and urinary proteome analysis

Adult Henoch-Schönlein purpura associated with small cell lung cancer: A case report and review of the literature

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