Henoch-Schönlein purpura associated with malignancy in adults

Zurada, Joanna M.; Ward, Kimberley M.; Grossman, Marc E.

doi:10.1016/j.jaad.2005.10.011

Cited by 91 publications

(75 citation statements)

References 28 publications

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“…However, patients with HSP associated with a malignancy are mostly older males with a mean age of 60 years (7,8,10,11). Neuroblastomas are the most common extracranial solid tumors in children, but there are no reports of children with HSP associated with a neuroblastoma as has been reported here.…”

Section: Introductionmentioning

confidence: 62%

“…In 2006, Zurada et al (11) reviewed literature on adult malignancy-associated HSP from around the world, and they found a total of 31 cases. Patients were overwhelmingly male (94%) with a mean age of 60 years and presented predominantly with solid tumors (61%) and secondly with hematologic malignancies (39%).…”

Section: Discussionmentioning

confidence: 99%

“…Based on these reports, HSP associated with a malignancy is characterized by: i) patients who are mainly older males (over 40-60 years: over 85%); ii) development within 1-3 months of diagnosis or metastasis of a neoplasm; iii) causes are mostly solid tumors (over 60%), and especially carcinoma of the lung, followed by hematologic malignancies (about 40%); and iv) development in the absence of a precipitating factor. This suggests that adults, and especially older men who present with unexplained HSP, should be evaluated for an occult neoplasm (5,6), while patients with a known history of malignancy who present with HSP should be evaluated for metastatic disease (11). A skin biopsy is an important way to determine the underlying pathology in adult HSP (17).…”

Section: Discussionmentioning

confidence: 99%

“…Many malignancies, such as solid tumors and hematologic malignancies, are reported to induce or be associated with HSP. Such tumors include carcinoma of the lung, bronchus, esophagus, stomach, intestine, breast, kidney, prostate, and thyroid (3)(4)(5)(6)(7)(8)(9)(10)(11)(12) while hematologic malignancies include non-Hodgkin lymphoma, Hodgkin disease, multiple myeloma, myeloproliferative disease, and myelodysplastic syndrome (10,11,(13)(14)(15)(16)(17).…”

Section: Introductionmentioning

confidence: 99%

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Henoch-Schönlein purpura associated with a neuroblastoma: Report of one case and a review of the literature

Dong

Cao

Zhang

et al. 2012

Intractable Rare Dis Res

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Section: Introductionmentioning

confidence: 62%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Henoch-Schönlein purpura associated with a neuroblastoma: Report of one case and a review of the literature

Dong

Cao

Zhang

et al. 2012

Intractable Rare Dis Res

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“…15 Hematological malignancies are more common in all vasculitis cases, while solid malignancies are more common in IgA vasculitis. 16 To our knowledge, there is no previous case in the literature of rectal tumor with IgA vasculitis.…”

Section: Discussionmentioning

confidence: 90%

Rectal Adenocarcinoma As An Uncommon Cause of Immunoglobulin A Vasculitis (Henoch-Schönlein Purpura)

et al. 2017

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A Common Purpuric Rash With Uncommon Association in a Woman With Pedal Edema

Akhtar

Mangla

2019

JAMA Oncol

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A 70-year-old Indian woman presented with a generalized rash over the lower extremity associated with pedal edema extending up to the shins. The onset was gradual and started on the lower extremities and gradually extended to involve the lower trunk. The rash was associated with mild discomfort. The patient denied itching, weeping, or bleeding from the rash. She denied any constitutional symptoms (weight loss, fever, night sweats), joint pains, history of blood in urine, periorbital edema, and recent intake of medications or herbal medications. Social history was significant for 25 pack-years of smoking. Physical examination revealed multiple well-defined, coalescent, erythematous, palpable, purpuralike lesions that were predominantly present over the trunk and lower extremities (Figure , A and B). Laboratory test results at presentation included a hemoglobin level of 11.2 g/dL (to convert to g/L, multiply by 10), mean corpuscular volume of 84 fL, erythrocyte sedimentation rate of 72 mm/h, and a lactate dehydrogenase level of 412 IU/L. Hepatic and renal function levels were within normal limits. Complement levels were normal. Hepatitis B and C and HIV profiles were negative. A chest radiograph showed a 2-cm lesion in the upper lobe of the left lung. A computed tomographic scan of the chest showed a spiculated mass in the same region along with mediastinal lymphadenopathy. An ultrasound of the abdomen showed bilateral adrenal masses. A lesional skin biopsy specimen was obtained (Figure , C).

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Henoch-Schönlein purpura associated with malignancy in adults

Cited by 91 publications

References 28 publications

Henoch-Schönlein purpura associated with a neuroblastoma: Report of one case and a review of the literature

Henoch-Schönlein purpura associated with a neuroblastoma: Report of one case and a review of the literature

Rectal Adenocarcinoma As An Uncommon Cause of Immunoglobulin A Vasculitis (Henoch-Schönlein Purpura)

A Common Purpuric Rash With Uncommon Association in a Woman With Pedal Edema

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