2021
DOI: 10.1002/dvdy.321
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Heparan sulfate proteoglycan expression in the regenerating zebrafish fin

Abstract: Background: Heparan sulfate proteoglycan (HSPG) expression is found in many animal tissues and regulates growth factor signaling such as of Fibroblast growth factors (Fgf), Wingless/Int (Wnt) and Hedgehog (HH). Glypicans, which are GPI (glycosylphosphatidylinositol)-anchored proteins, and transmembrane-anchored syndecans represent two major HSPG protein families whose involvement in development and disease has been demonstrated. Their participation in regenerative processes both of the central nervous system a… Show more

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Cited by 12 publications
(5 citation statements)
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“…FGF20a, a paralog of FGF20, is required for fin regeneration and was found to directly regulate the expression of Lamb1a, providing a function for FGF20a in formation of a signaling‐competent regeneration epidermis (C. H. Chen, Merriman, et al, 2015). Gene expression analyses in zebrafish identified HSPGS (glypicans and syndecans) in the distal and lateral basal layers of the wound epidermis, the distal most blastema, and more proximal blastema regions, as potential regulators of growth factor signaling (Keil et al, 2021). FGF20a, and FGF3 and FGF10a, were the major FGF ligands expressed in the wound epidermis and blastema, respectively.…”
Section: Selected Topics In Genetics Development Regeneration and Dis...mentioning
confidence: 99%
“…FGF20a, a paralog of FGF20, is required for fin regeneration and was found to directly regulate the expression of Lamb1a, providing a function for FGF20a in formation of a signaling‐competent regeneration epidermis (C. H. Chen, Merriman, et al, 2015). Gene expression analyses in zebrafish identified HSPGS (glypicans and syndecans) in the distal and lateral basal layers of the wound epidermis, the distal most blastema, and more proximal blastema regions, as potential regulators of growth factor signaling (Keil et al, 2021). FGF20a, and FGF3 and FGF10a, were the major FGF ligands expressed in the wound epidermis and blastema, respectively.…”
Section: Selected Topics In Genetics Development Regeneration and Dis...mentioning
confidence: 99%
“…Glycosaminoglycans like heparan sulphate proteoglycans are associated with zebrafish fin regeneration [48], and axolotl limb regeneration [49,50]. Hyaluronan and proteoglycan link protein 3 was upregulated in the regenerating epithelium of axolotl limbs [51] and chondroitin sulphate proteoglycans are necessary for axonal regeneration and growth [52].…”
Section: Discussionmentioning
confidence: 99%
“…In addition to HBGAs, norovirus has also been shown to bind other ligands such as heparan sulfate or citrate ( 52 , 53 ). Hence, it may be that zebrafish larvae express certain additional ligands to which HuNoV is able to bind ( 54 , 55 ).…”
Section: Discussionmentioning
confidence: 99%