Heparin coating on 3D printed poly (l-lactic acid) biodegradable cardiovascular stent via mild surface modification approach for coronary artery implantation

Lee, Sang Jin; Jo, Ha Hyeon; Lim, Kyung Seob; Lim, Dohyung; Lee, Soojin; Lee, Jun Hee; Kim, Wan Doo; Cho, Jeong Gwan; Lim, Joong Yeon; Kwon, Il Keun; Jung, Youngmee; Park, Jun-Kyu; Park, Su A

doi:10.1016/j.cej.2019.122116

Cited by 99 publications

(61 citation statements)

References 80 publications

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“…Subsequently, the catechol groups conjugate with the nucleophilic amine groups of PEI to bind the surface modification onto the Ti implant [17]. In our recent previous report, Lee et al demonstrated that the PDA deposition of PEI coating provides a lot of opportunity for grafting of carboxyl group bearing molecules due to many amine units [19]. Through these experiments, we clearly demonstrated changes in surface composition and morphology (Fig.…”

Section: Discussionsupporting

confidence: 54%

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Facile preparation of mussel-inspired antibiotic-decorated titanium surfaces with enhanced antibacterial activity for implant applications

Lee

Yang

et al. 2019

Applied Surface Science

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Titanium implants (Ti) have been widely used in several medical fields. In clinical practice, Ti can become contaminated with bacteria through a variety of mechanisms. This contamination can lead to implant failure and serious infections. In this study, we aimed to develop a new, hybrid Ti with good biocompatibility and antibacterial properties by immobilizing ceftazidime (CFT) onto the Ti surface through polydopamine (PDA) and polyethyleneimine (PEI) chemistry. Hybrid Ti was confirmed by assessing the cell proliferation of human adipose-derived stem cells using a cell counting. The biofilm formation across the Ti surface of two bacterial strains associated with nosocomial infections, Pseudomonas aeruginosa and methicillin-resistant Staphylococcus aureus, was evaluated by scanning electron microscopy. The viability of the bacteria exposed to Ti surface was evaluated by cell counting. Our results clearly demonstrate that the bacterial biofilm formation as well as bacterial viability was significantly reduced on the hybrid Ti as compared to the control, Ti alone. Collectively, the Ti surface was successfully modified to form the hybrid Ti exhibiting good biocompatibility and antibacterial properties through PDA, PEI, and CFT grafting. Within the limitations of this in vitro study, we conclude that the hybrid Ti may be useful for successful implant treatment.

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Section: Discussionsupporting

confidence: 54%

“…Specific surface treatment procedure was performed following an our recent previously reported with some modifications [19]. Briefly, Ti discs were washed 3 times and cleaned in an ultra-sonicator for 10 min using hexane, acetone, ethanol and distilled water, sequentially, prior to use [20].…”

Section: Preparation Of Pda and Pei Coated Ti Substratementioning

confidence: 99%

Facile preparation of mussel-inspired antibiotic-decorated titanium surfaces with enhanced antibacterial activity for implant applications

Lee

Yang

et al. 2019

Applied Surface Science

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“… 13 Commonly used biodegradable (or soluble), biocompatible, and U.S. Food and Drug Administration (FDA)-approved polymers include poly(lactic acid) (PLA), poly(vinyl alcohol) (PVA), and poly(caprolactone) (PCL). 5 , 14 − 16 These polymers have been widely used for biomedical applications including cardiovascular stents 15 and implants. 5 , 14 , 16 , 17 …”

Section: Introductionmentioning

confidence: 99%

Poly(caprolactone)-Based Coatings on 3D-Printed Biodegradable Implants: A Novel Strategy to Prolong Delivery of Hydrophilic Drugs

et al. 2020

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Implantable devices are versatile and promising drug delivery systems, and their advantages are well established. Of these advantages, long-acting drug delivery is perhaps the most valuable. Hydrophilic compounds are particularly difficult to deliver for prolonged times. This work investigates the use of poly(caprolactone) (PCL)-based implant coatings as a novel strategy to prolong the delivery of hydrophilic compounds from implantable devices that have been prepared by additive manufacturing (AM). Hollow implants were prepared from poly(lactic acid) (PLA) and poly(vinyl alcohol) (PVA) using fused filament fabrication (FFF) AM and subsequently coated in a PCL-based coating. Coatings were prepared by solution-casting mixtures of differing molecular weights of PCL and poly(ethylene glycol) (PEG). Increasing the proportion of low-molecular-weight PCL up to 60% in the formulations decreased the crystallinity by over 20%, melting temperature by over 4 °C, and water contact angle by over 40°, resulting in an increased degradation rate when compared to pure high-molecular-weight PCL. Addition of 30% PEG to the formulation increased the porosity of the formulation by over 50% when compared to an equivalent PCL-only formulation. These implants demonstrated in vitro release rates for hydrophilic model compounds (methylene blue and ibuprofen sodium) ranging from 0.01 to 34.09 mg/day, depending on the drug used. The versatility of the devices produced in this work and the range of release rates achievable show great potential. Implants could be specifically developed in order to match the specific release rate required for a number of drugs for a wide range of conditions.

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“…In recent years, many research groups have been working to improve the DES available on the market. The design of the third-generation DES focuses mainly on solving problems related to the use of older DES, primarily focusing on the prevention of restenosis, acute thrombosis, and LST (Leucocyte Specific Transcript) [ 160 ]. The demand for the third generation of stents is still enormous, because stent implantation is a widely used, rapidly developing technique in the clinical treatment of coronary artery disease.…”

Section: New Stent Systemsmentioning

confidence: 99%

“…All these assessments confirmed that the presented innovative strategy proposes a useful model as a method of preparing a fully biodegradable individual stent for successful implantation therapy. It would be widely used in clinical cardiac applications [ 160 ].…”

Section: New Stent Systemsmentioning

confidence: 99%

Drug-Eluting Stents and Balloons—Materials, Structure Designs, and Coating Techniques: A Review

Rykowska

Nowak

Nowak³

2020

Molecules

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Controlled drug delivery is a matter of interest to numerous scientists from various domains, as well as an essential issue for society as a whole. In the treatment of many diseases, it is crucial to control the dosing of a drug for a long time and thus maintain its optimal concentration in the tissue. Heart diseases are particularly important in this aspect. One such disease is an obstructive arterial disease affecting millions of people around the world. In recent years, stents and balloon catheters have reached a significant position in the treatment of this condition. Balloon catheters are also successfully used to manage tear ducts, paranasal sinuses, or salivary glands disorders. Modern technology is continually striving to improve the results of previous generations of stents and balloon catheters by refining their design, structure, and constituent materials. These advances result in the development of both successive models of drug-eluting stents (DES) and drug-eluting balloons (DEB). This paper presents milestones in the development of DES and DEB, which are a significant option in the treatment of coronary artery diseases. This report reviews the works related to achievements in construction designs and materials, as well as preparation technologies, of DES and DEB. Special attention was paid to the polymeric biodegradable materials used in the production of the above-mentioned devices. Information was also collected on the various methods of producing drug release coatings and their effectiveness in releasing the active substance.

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Heparin coating on 3D printed poly (l-lactic acid) biodegradable cardiovascular stent via mild surface modification approach for coronary artery implantation

Cited by 99 publications

References 80 publications

Facile preparation of mussel-inspired antibiotic-decorated titanium surfaces with enhanced antibacterial activity for implant applications

Facile preparation of mussel-inspired antibiotic-decorated titanium surfaces with enhanced antibacterial activity for implant applications

Poly(caprolactone)-Based Coatings on 3D-Printed Biodegradable Implants: A Novel Strategy to Prolong Delivery of Hydrophilic Drugs

Drug-Eluting Stents and Balloons—Materials, Structure Designs, and Coating Techniques: A Review

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