Heparin in the treatment of hypofibrinogenemia complicating fetal death in utero

Lerner, Robert G.; Margolin, Malcolm; Slate, William G.; Rosenfeld, Howard

doi:10.1016/0002-9378(67)90501-7

Cited by 20 publications

(8 citation statements)

References 12 publications

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“…Intravascular coagulation has been widely incriminated as the usual cause of fibrinogen depletion in patients with a retained dead foetus (Pritchard, 1959;Hardisty and Ingram, 1965). The report of Lerner et al (1967) that the depleted coagulation factors after intrauterine death were corrected by the administration of heparin alone, without blood or fibrinogen, and our findings of raised serum F.D.P. after intrauterine death are strong evidence that intravascular coagulation is the mechanism responsible for the depletion of the clotting factors.…”

Section: Medibal Journalsupporting

confidence: 68%

Fibrin Degradation Products in Normal and Abnormal Pregnancy and Parturition

Bonnar¹,

Davidson²,

Pidgeon³

et al. 1969

BMJ

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Section: Medibal Journalsupporting

confidence: 68%

Fibrin Degradation Products in Normal and Abnormal Pregnancy and Parturition

Bonnar¹,

Davidson²,

Pidgeon³

et al. 1969

BMJ

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“…In particular, a woman carrying a dead fetus for a period longer than four This paper was presented at the Annual Armed Forces Obstetrical and Gynecology District Meeting, New Orleans, LA, October 12, 1977 weeks may show an abnormal coagulation profile, with or without clinically evident bleeding (11). T h e demonstration that heparin can correct these abnormalities (5,6,8,10) supports the thesis that consumption coagulopathy is an intermediary mechanism.…”

Section: Introductionmentioning

confidence: 63%

Consumption Coagulopathy Associated With Intrauterine Fetal Death: The Role of Heparin Therapy

Strauss

Ballard

Chamlian

1978

Intl J Gynecology & Obste

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A gravida with intrauterine fetal death who developed progressive chronic consumption coagulopathy was treated with heparin. When serial fibrinogen levels fell below 100 mg% and the prothrombin time was significantly prolonged, intravenously injected heparin corrected hypofibrinogenemia. A safe delivery followed administration of oxytocin. The authors emphasize the infrequent need for heparin therapy in the majority of cases of the intrauterine fetal death syndrome. Therapeutic guidelines for its use in selected cases are reviewed.

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“…Fifteen had their fibrinogen concentrations measured. The range was 2-5-6-0 g/l (mean [3][4][5][6][7] (1-0) gIl). None range.…”

Section: Commentmentioning

confidence: 99%

“…In reviewing 14 papers from this era (over 133 cases) we found only two cases in which coagulation abnormalities occurred-within five weeks after presumed fetal death, one after four weeks' and one after 14 days.2 A case was described in an unbooked patient 10 days after "movements ceased," but the clinical history and examination suggested a much longer period of intrauterine death. 3 One study reported more than 100 women who had retained a dead fetus in utero for more than one week, 50 ofthem for longer than five weeks (range 5-19 weeks, mean eight weeks).4 Fibrinogen concentrations started to fall after three to four weeks, but this was not clinically important before five weeks. After five weeks about 25% of women developed defective haemostatic function.…”

Section: Commentmentioning

confidence: 99%