Heparin‐like anticoagulants in asthma

Lasser, Elliott C.; Simon, Ronald A.; Lyon, Sandra; Hamblin, A E; Stein, R. E. K.

doi:10.1111/j.1398-9995.1987.tb00393.x

Cited by 38 publications

(21 citation statements)

References 28 publications

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“…Heparin-like material was demonstrated in the blood of patients with peripheral arterial occlusive disease, all of whom showed an increased coagulation tendency compared with healthy controls, in a manner that correlated with disease severity (Shankar et al, 2008). By contrast, patients with allergic disease have an increased level of circulating "heparin-like material" and these patients have been suggested to have less calcification of the major arteries, suggestive of a role for endogenous heparin in preventing cardiovascular problems (Lasser et al, 1987). Human mast cells have been reported to release heparin after allergen stimulation (Green et al, 1993).…”

Section: F Endogenous Heparinmentioning

confidence: 96%

“…Many proteins display basic amino acid residues on their surfaces, sometimes clustered into patches of positive charge that form socalled heparin binding domains. Because heparin itself is located in mast cell granules, liberated into the surrounding tissue only briefly on degranulation (Green et al, 1993;Wang and Kovanen, 1999), it is likely to come into contact with only the subset of proteins found in mast cell granules, the immediate ECM and possibly the circulation, as elevated levels of heparin-like material have been measured in patients with allergic diseases who undergo regular mast cell degranulation (Lasser et al, 1987). Interestingly, such patients also have a mild hemostatic defect consistent with elevated heparin levels in the circulation (Szczeklik et al, 1991).…”

Section: B Heparin Interactions With Proteinsmentioning

confidence: 99%

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Pharmacology of Heparin and Related Drugs

et al. 2015

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Section: F Endogenous Heparinmentioning

confidence: 96%

Section: B Heparin Interactions With Proteinsmentioning

confidence: 99%

Pharmacology of Heparin and Related Drugs

et al. 2015

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“…More importantly, we have demonstrated that this process proceeds more rapidly in atopic or asthmatic individuals than in individuals without these abnormalities [1]. Asthmatics can be demonstrated to have higher concentrations than do nonasthmatics of heparin/heparan sulfate when these molecules are isolated from their neutralizing substances [2, 3] (Figure 3). …”

Section: Activation Of the Contact System And Negative Surfacesmentioning

confidence: 99%

X-Ray Contrast Media Mechanisms in the Release of Mast Cell Contents: Understanding These Leads to a Treatment for Allergies

Lasser¹

2011

Journal of Allergy

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A long history of searching for the etiology of X-ray contrast material (CM) reactions has led to the understanding that the CM do not produce anti-CM antigens. Since CM reactions are anaphylactoid in nature, however, a source for mast cell activation was sought. This resulted in the finding that concentrated CM could suppress mast cell activation by attachment to the Fc portion of IgE and IgG. This is presumed to be a steric hindrance effect. In a study of the effects of CM on BP and a study of the effects of CM in sensitized rats, it was concluded that less concentrated CM activated mast cells and that this mechanism was best explained by bridging of adjacent IgE molecules via attachment to their Fc segments. The mast cell release of heparin activating the contact system, as well as the release of histamine, is believed to be responsible for CM reactions and allergic diatheses.

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“…In addition, an increased level of an endogenous 'heparin-like material' has been reported in the plasma of allergic subjects (Lasser et al, 1987). Heparin has been shown to inhibit activation of the complement system (Kazatchkine et al, 1981;Ekre et al, 1986), neutrophil chemotaxis (Matzner et al, 1984) and eosinophil infiltration (Hanss et al, 1989;Seeds & Page, 1992).…”

Section: Introductionmentioning

confidence: 99%

Effect of heparin and a low‐molecular weight heparinoid on PAF‐induced airway responses in neonatally immunized rabbits

Sasaki

Herd

Page

1993

British J Pharmacology

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We have investigated the effect of an unfractionated heparin preparation, a low‐molecular weight heparinoid (Org 10172) and the polyanionic molecule polyglutamic acid against PAF‐induced airway hyperresponsiveness and pulmonary cell infiltration in neonatally immunized rabbits in vivo. Exposure of neonatally immunized rabbits to aerosolized platelet activating factor (PAF) (80 μg ml−1 for 60 min) elicited an increase in airway responsiveness to inhaled histamine 24 h and 72 h following challenge which was associated with an infiltration of inflammatory cells into the airways, as assessed by bronchoalveolar lavage (BAL). A significant increase in the total numbers of cells recovered from BAL fluid was associated with significantly increased cell numbers of neutrophils, eosinophils and mononuclear cells 24 h following PAF exposure. The numbers of eosinophils and neutrophils in the airways remained elevated 72 h after challenge. The intravenous administation of an unfractionated preparation of heparin (100 units kg−1) or Org 10172 (100 μg kg−1) 30 min prior to PAF exposure significantly inhibited the airway hyperresponsiveness induced by PAF, 24 h and 72 h following challenge. PAF‐induced hyperresponsiveness was not significantly affected by prior intravenous administration of polyglutamic acid (100 μg kg−1). The intravenous administration of unfractionated heparin (100 units kg−1), Org 10172 (100 μg kg−1) or polyglutamic acid (100 μg kg−1) 30 min prior to PAF exposure significantly inhibited the expected increase in total cell infiltration. This study shows that unfractionated heparin and a low‐molecular weight heparinoid, Org 10172, are capable of inhibiting both the airway hyperresponsiveness and pulmonary cell infiltration induced by PAF in the rabbit.

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Heparin‐like anticoagulants in asthma

Cited by 38 publications

References 28 publications

Pharmacology of Heparin and Related Drugs

Pharmacology of Heparin and Related Drugs

X-Ray Contrast Media Mechanisms in the Release of Mast Cell Contents: Understanding These Leads to a Treatment for Allergies

Effect of heparin and a low‐molecular weight heparinoid on PAF‐induced airway responses in neonatally immunized rabbits

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