Heparinassoziierte Thrombocytopenie (HAT) Typ II Eine unterschätzte Komplikation der Thromboembolieprophylaxe mit Heparin

M, Oberst; Vierling, P; Thielemann, F. W.

doi:10.1007/s001040050396

Cited by 2 publications

(1 citation statement)

References 11 publications

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“…This results in respiratory compromise due to a significantly raised hemi-diaphragm and a drop in cardiac output as a result of decreased venous return. It was first reported by Oberst [ 10 ], in 1917, in a case of grenade-induced gastric perforation where the liver was postulated to be lying over the perforation and acting as a one-way valve allowing the air to escape into but not out of the peritoneal cavity. Both spontaneous or iatrogenic bowel perforation (e.g., following endoscopy) may result in tension pneumoperitoneum and have been reported in the literature [ 11 ].…”

Section: Discussionmentioning

confidence: 99%

Tension Pneumoperitoneum: A Rare Complication of Cardiopulmonary Resuscitation (CPR)

Samee,

Zubair

et al. 2024

Cureus

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Tension pneumoperitoneum is a surgical emergency. Although rare, failure to diagnose and treat the condition may be lethal. Hence, being aware of this phenomenon, particularly in scenarios involving cardiopulmonary resuscitation (CPR), is important. Existing literature emphasises immediate abdominal needle decompression as the initial management followed by close monitoring and keeping a low threshold for surgical intervention as a definitive measure. We decided to write up this case report to raise awareness that a tension pneumoperitoneum can result as a complication of CPR, a well-known and widely practiced algorithm.

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Section: Discussionmentioning

confidence: 99%

Tension Pneumoperitoneum: A Rare Complication of Cardiopulmonary Resuscitation (CPR)

Samee,

Zubair

et al. 2024

Cureus

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Heparin-induced thrombocytopenia (HIT)

Magnani¹,

Gallus²

2006

Thromb Haemost

100

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Clinical outcomes of 1,478 danaparoid treatment case reports for HIT (involving 1,418 patients) treated between 1982 and mid-2004 are analysed. Treatment in 1,291 episodes was for current HIT. Thromboembolism due to HIT was present in 39.4%. The patients include 33 children and 32 pregnancies. Two hundred twenty-six patients required extra-corporeal circuit use for renal failure, 241 patients had a concomitant thrombophilic disorder, and 351 major operations were performed. Clinical outcomes were assessed during danaparoid treatment (range one day to 3.5 years) plus three months of follow-up. Of the danaparoid-treated patients 83.8% survived; 63.7% had no or minor adverse events and 20.1% suffered serious non-fatal adverse events. New thromboses occurred during 9.7% of treatment episodes, and 16.4% of treatment episodes had an inadequate treatment response (i. e. developed one or more of the following: new/extended thrombosis, persistent/new platelet count reduction, unplanned amputation during treatment and follow-up). Major bleeding was reported in 8.1% of treatment episodes. Clinical cross-reactivity of danaparoid (new/persistent platelet count reduction and/or new/extended thrombosis) was confirmed serologically in 23 of 36 patients with positive pretreatment serological danaparoid cross-reactivity and in 22 of 32 additional patients tested at the time of the new event, i.e. a total of 45 patients (3.2%). Clinical outcomes of these case reports of patients given danaparoid because of suspected or confirmed HIT appear to be comparable with those reported by others who used direct thrombin inhibitors, especially when a sufficient danaparoid dosing intensity was used in patients with isolated HIT. Post-operative bleeding limits danaparoid use for cardiopulmonary by-pass surgery. Routine clinical and platelet count monitoring are required to minimise adverse reactions due to cross-reactivity.

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Heparinassoziierte Thrombocytopenie (HAT) Typ II Eine unterschätzte Komplikation der Thromboembolieprophylaxe mit Heparin

Cited by 2 publications

References 11 publications

Tension Pneumoperitoneum: A Rare Complication of Cardiopulmonary Resuscitation (CPR)

Tension Pneumoperitoneum: A Rare Complication of Cardiopulmonary Resuscitation (CPR)

Heparin-induced thrombocytopenia (HIT)

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