2017
DOI: 10.1186/s12893-017-0215-0
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Hepatectomy for liver metastases from gastric cancer: a systematic review

Abstract: BackgroundOfficial guidelines recommend palliative treatments for patients with liver metastases from gastric cancer. However, many case series reported that hepatectomy for such cases is safe and effective. This systematic review compares the overall survival between hepatectomy and palliative therapy in patients with liver metastases from gastric cancer.MethodsTwo independent reviewers performed a systematic search of literature in EMBASE and PubMed, updated until 26 October 2016. The Newcastle-Ottawa score … Show more

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Cited by 34 publications
(24 citation statements)
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“…Compared to the results of randomized controlled trials based on chemotherapy, hepatectomy seems to offer in selected patients better survival outcomes [59,60] . Liao et al [61] , consistent with previous reviews, described significantly improved overall survival in patients treated with hepatectomy compared to palliative chemotherapy. In light of these studies, the Japanese guidelines reconsidered the role of hepatectomy in the treatment of liver metastasis in gastric cancer, however, which patients may actually benefit from surgical treatment is still controversial.…”
Section: Discussionsupporting
confidence: 64%
“…Compared to the results of randomized controlled trials based on chemotherapy, hepatectomy seems to offer in selected patients better survival outcomes [59,60] . Liao et al [61] , consistent with previous reviews, described significantly improved overall survival in patients treated with hepatectomy compared to palliative chemotherapy. In light of these studies, the Japanese guidelines reconsidered the role of hepatectomy in the treatment of liver metastasis in gastric cancer, however, which patients may actually benefit from surgical treatment is still controversial.…”
Section: Discussionsupporting
confidence: 64%
“…3 Despite the fact that chemotherapy is the recommended treatment in advanced and recurrent GC, it does not achieve long survival. [4][5][6] Recent studies support hepatectomy (Hp) as an alternative in selected patients with GCLM, with promising results of 5-year survival rates of about 30%. [7][8][9][10] However, Hp in the treatment of gastric carcinoma liver metastases (GCLM) is still controversial.…”
Section: Introductionmentioning
confidence: 99%
“…However, less than 30% of patients eligible for curative resection because the majority of gastric cancer cases present in advanced stage due to late onset and nonspecific symptoms. [ 2 ] In recent decade, although treatment of gastric cancer has been significantly improved, the prognoses of patients represented by liver metastases is extremely poor, with a 3-year overall survival (OS) lower than 40% even after hepatectomy, [ 2 ] or less than 10% after chemotherapy. [ 3 ] Therefore, exploring tumor markers to predict patients’ prognoses has important clinical value to prolong their survival time.…”
Section: Introductionmentioning
confidence: 99%