Hepatic and gastric cytoprotective effects of long-term prostaglandin E1 administration in cirrhotic rats

Beck, Paul L.; McKnight, G. Webb; Kelly, James K.; Wallace, John L.; Lee, Samuel S.

doi:10.1016/0016-5085(93)90155-6

Cited by 46 publications

(37 citation statements)

References 29 publications

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“…5 Therefore, we examined the spectrum of prostaglandins made by isolated Kupffer cells or by mixed nonparenchymal cells exposed to CCl 4 ( Table 5). As expected, PGD 2 was the most abundant of F 2 -isoprostane into the cell culture medium in response to CCl 4 . Hepatocytes from these two livers did not release PGE 2 when exposed to CCl 4 .…”

Section: Prostaglandin Synthesis In Nonparenchymal Cells Exposedsupporting

confidence: 82%

“…Ricin-purified hepatocytes exposed to CCl 4 made approximately the same amount of PGF 2a -like immucytes themselves do not make thromboxane.…”

Section: Response Of Hepatocytes To CCLmentioning

confidence: 87%

“…Arachidonic acid metabolites play important roles in liver CCl 4 . The release of unesterified fatty acids was measured physiology.…”

Section: Release Of Arachidonic Acid From Hepatocytes Exposed Tomentioning

confidence: 99%

“…The chamber was quickly flushed with humidified 5% CO 2 -balanced RESULTS air at 5 L/m for 90 seconds. The inflow port was sealed, and tubing 4 . Monolayers of convenfrom the outflow port was put under a water seal to allow for gas expansion.…”

mentioning

confidence: 99%

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Stimulation of Prostaglandin Synthesis in Cultured Liver Cells by Ccl4

Johnston

Kroening

1996

Hepatology

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(PGD 2 ) and smaller amounts of prostaglanThe contribution of hepatocytes to liver prostaglandin din E 2 (PGE 2 ), prostaglandin F 2a (PGF 2a ), and other arachisynthesis is controversial, partly because hepatocytes of donic acid metabolites. 5 However, there is no consensus varying purity have been studied. In this study, prostawhether hepatocytes have an active cyclooxygenase pathglandin synthesis was examined in conventional and riway. 1 We previously studied this question using homogenates cin-purified rat hepatocytes that were incubated with of primary rat hepatocytes purified with ricin A chain, 6

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Section: Prostaglandin Synthesis In Nonparenchymal Cells Exposedsupporting

confidence: 82%

“…Ricin-purified hepatocytes exposed to CCl 4 made approximately the same amount of PGF 2a -like immucytes themselves do not make thromboxane.…”

Section: Response Of Hepatocytes To CCLmentioning

confidence: 87%

“…Arachidonic acid metabolites play important roles in liver CCl 4 . The release of unesterified fatty acids was measured physiology.…”

Section: Release Of Arachidonic Acid From Hepatocytes Exposed Tomentioning

confidence: 99%

mentioning

confidence: 99%

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Stimulation of Prostaglandin Synthesis in Cultured Liver Cells by Ccl4

Johnston

Kroening

1996

Hepatology

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“…[17][18] Furthermore, as the severity of PHG increases it results in a higher hemokinetic stress as compared to those who have mild PHG based on the endoscopic laser Doppler flowmetry. Many of the international studies have tried to observe the direct and indirect relation with many of the internal and external factors that affect or damage the portal hypertensive mucosa, they have come to know that there is an increased in the damaging effect when generation of prostaglandin E2 decreases in PHG.…”

mentioning

confidence: 99%

Cirrhotic Patients; Prevalence of Portal Hypertensive Gastropathy Undergoing Upper Gastrointestinal Endoscopy at a Tertiary Care Hospital in Shaheed Benazeerabad

Sahto¹,

Shahzad²,

Sahito³

2016

TPMJ

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ABSTRACT… Objectives:The aim behind this study was to determine the prevalence of portal hypertensive gastropathy in cirrhotic patients undergoing upper gastrointestinal endoscopy at a tertiary care hospital in Shaheed Benazeerabad. Study Design: Hospital based cross sectional study. Setting: Medicine Department of People's Medical University, Shaheed Benazeerabad. Period: Six months from 20 th August 2014 to 21 st February 2015. Material and Methods: A total of 115 patients presenting with variceal bleeding (having history of liver cirrhosis since >2 years) and who further was undergoing diagnostic Endoscopic gastrodudenoscopy were enrolled in the study. All endoscopies were performed by the endoscopists using a GIFQ 160 Gastroscope (Olympus, Tokyo, Japan) in the left lateral position. The presence or absence of PH gastropathy (outcome variable) was noted at each endoscopy. SPSS version 17.0 was used to analyze the collected data. Results: The average age of the patients was 39.98±11.02 years and mean duration of liver cirrhosis was 4.62±1.5 years. There were 70 (60.87%) male and 45 (39.13%) were female. Regarding socioeconomic status, most of the cases were in lower and middle class. Frequency of portal hypertensive gastropathy (PHG) in patients of liver cirrhosis undergoing upper gastrointestinal endoscopy was observed in 60% (69/115) cases. Conclusion: The frequency of PHG was 60% in the studied group of cirrhotic patients. This concludes that if in the liver cirrhosis patients early identification and appropriate therapeutic measures of PHG is taken the morbidity in these patients can be decreased.

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