Hepatic and skeletal muscle glycogen metabolism in rats with short-term cholestasis

Protective effect of low dose of melatonin against cholestatic oxidative stress after common bile duct ligation in rats

“…Recent studies have reported a decrease in serum glucose values [17] and hepatic glycogen content [31,32] . We have observed nearly a total loss in the amount of glycogen in hepatocytes.…”

Hepatic carbohydrate metabolism in rats after laparotomy and laparoscopy

“…Refeeding after starvation replenishes the hepatic glycogen stores within at least 2 days [12]. In another study, we were able to show that reduced intake of food is the main cause for the observed decrease in the hepatic glycogen stores during the first 4 days after bile duct ligation [27]. In that study, bile duct-ligated animals lost approximately 10% of their body weight.…”

“…Starvation and markedly reduced intake of food for 24 h or longer are well-known to decrease the hepatic glycogen stores due to increased glycogenesis to maintain the plasma glucose concentrations in a physiological range [3,12,26,27,32]. Refeeding after starvation replenishes the hepatic glycogen stores within at least 2 days [12].…”

“…Data from our laboratory showed that in rats with short-term cholestasis, a reduction in the hepatic glycogen content can be found very early after bile duct ligation (laparotomy). Immediately after surgery, impaired food intake was proposed as a potential mechanism, and endotoxinemia was the suspected reason for reduced hepatic glycogen stores 4-8 days after surgery [27].Conventional open surgery is accompanied by disturbed hemodynamic, metabolic, hormonal, and systemic immunological changes during the early postoperative phase [9,11,39]. Studies have shown that such alterations are less accentuated after laparoscopic surgery [9,11,20,38,39].…”

“…Data from our laboratory showed that in rats with short-term cholestasis, a reduction in the hepatic glycogen content can be found very early after bile duct ligation (laparotomy). Immediately after surgery, impaired food intake was proposed as a potential mechanism, and endotoxinemia was the suspected reason for reduced hepatic glycogen stores 4-8 days after surgery [27].…”