Hepatic angiosarcoma manifested as recurrent hemoperitoneum

Lee, Seung-Woo; Song, Chun-Young; Gi, Young-Hwa; Kang, Sang-Beom; Kim, Yonsoo; Nam, Soon-Woo; Lee, Dong‐Soo; Kim, Jong-Ok

doi:10.3748/wjg.14.2935

Cited by 36 publications

(26 citation statements)

References 22 publications

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“…Intraperitoneal haemorrhage following tumour rupture appears to be a relatively common method of acute presentation (2,4,5,14,15), usually accompanied by a high mortality risk due to exsanguination (2,4,15). Survivors usually present with a herald bleed, as in our case.…”

Section: Discussionmentioning

confidence: 74%

Herald bleeding from a ruptured primary hepatic angiosarcoma: A case report

Cawich

Ramjit

2015

Molecular and Clinical Oncology

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Abstract. Primary hepatic angiosarcomas (PHAs) are rare tumours with an estimated annual incidence of 0.05 per million in the Caribbean, which is similar to that reported in Western countries. Although a number of cases are detected post-mortem, the most common clinical presentation is with tumour rupture and herald bleeding. This is the case report of a 60-year old female patient who presented with vague upper abdominal pain, found via imaging examinations to be due to a ruptured hepatic tumour in segment III of the liver. The tumour was removed via laparoscopic left lateral sectionectomy, with clear resection margins. The histopathological and immunohistochemical examination established the diagnosis of PHA. Therefore, an index of suspicion should be maintained in selected patients and, when detected ante-mortem, PHAs should be treated aggressively with complete surgical resection to achieve microscopically clear margins, as the response of these tumours to other forms of adjuvant therapy may be unpredictable.

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Section: Discussionmentioning

confidence: 74%

Herald bleeding from a ruptured primary hepatic angiosarcoma: A case report

Cawich

Ramjit

2015

Molecular and Clinical Oncology

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“…Clinical studies that are useful for the diagnosis are ultrasounds that show the areas of heterogeneous echogenicity, sometimes with data suggesting central necrosis; in the CT, one can observe areas of hypodensity in the hepatic parenchyma,3 which may alternate with other hypodense areas corresponding to haemorrhages 13…”

Section: Discussionmentioning

confidence: 99%

“…Because of the vascular nature of such tumours, a high incidence of haemorrhage as a complication have been reported 3 5. For this reason, it is suggested that, when possible, a transjugular biopsy be performed.…”

Section: Discussionmentioning

confidence: 99%

Angiosarcoma of the liver as a cause of fulminant liver failure

García

Cabello

Feregrino³

et al. 2012

BMJ Case Reports

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Primary liver sarcomas make up 2% of all malignant neoplasms of the liver; of these, angiosarcoma is the most common type. Primary liver tumours rarely cause fulminant hepatic failure (FHF), which is most frequently caused by non-neoplasmic pathologies. In the case of neoplasms, the most frequent are lymphoma and metastatic carcinomas. We describe the case of a 76-year-old man who suffered from FHF as a result of a liver angiosarcoma and we present a review of the medical literature in which we found only two cases of liver angiosarcomas linked to FHF.

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“…Because of the rich vascularization of this tumor, it is not unusual to encounter spontaneous hemorrhagic complications and in 26.6% of cases the presenting sign is a hemoperitoneum, which may also recur [42,43]. Simple embolization (Fig.…”

Section: Other Primary Hemorrhagic Liver Tumorsmentioning

confidence: 96%

Hemostastic embolization in oncology

Revel-Mouroz

Mokrane

Collot

et al. 2015

Diagnostic and Interventional Imaging

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Several mechanisms predispose to bleeding in neoplastic disease. This is all the more serious as it often occurs on a background of medically vulnerable patients and the magnitude of the bleed may lead to hemorrhagic shock or acute respiratory distress as a result of hemoptysis. It often carries a poor prognosis, even if the acute episode has been controlled, as bleeding due to rupture of a tumor often indicates an advanced stage of the disease, and also because tumor rupture carries a risk of metastatic spread including peritoneal carcinomatosis. The risk of recurrent bleeding is also not insignificant. In most cases, endovascular hemostatic embolization is the first line palliative treatment.

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Hepatic angiosarcoma manifested as recurrent hemoperitoneum

Abstract: Angiosarcoma is a rare tumor that account for less than 1% of all sarcomas. Although hepatic angiosarcoma usually presents with unspecific symptoms, it rapidly progresses and has a high mortality. We report a rare case of primary hepatic angiosarcoma manifested as recurrent hemoperitoneum.

Cited by 36 publications

References 22 publications

Herald bleeding from a ruptured primary hepatic angiosarcoma: A case report

Herald bleeding from a ruptured primary hepatic angiosarcoma: A case report

Angiosarcoma of the liver as a cause of fulminant liver failure

Hemostastic embolization in oncology

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