Hepatic arterial infusion chemotherapy using high-dose 5-fluorouracil and cisplatin with or without interferon-α for the treatment of advanced hepatocellular carcinoma with portal vein tumor thrombosis

Abstract

HAIC using high-dose 5-FU plus cisplatin achieved a good tumor response. Adding IFN-alpha did not show any additional beneficial effects in terms of tumor response rate or survival.

Effect of hepatic arterial infusion chemotherapy of 5-fluorouracil and cisplatin for advanced hepatocellular carcinoma in the Nationwide Survey of Primary Liver Cancer in Japan

“…Hepatic arterial infusion of cisplatin and 5-FU using a subcutaneous infusion port has been widely used in Japan to treat advanced HCC because of its relatively high response rate (27.8–57.1%) (Ando et al , 2002; Eun et al , 2009; Ueshima et al , 2010; Kim do et al , 2011; Kim et al , 2011); however, no randomized control trial has been conducted to demonstrate its effectiveness and survival benefit. Most reports of HAIC were retrospective studies with small numbers of patients.…”

Randomized, Phase II Study Comparing Interferon Combined with Hepatic Arterial Infusion of Fluorouracil plus Cisplatin and Fluorouracil Alone in Patients with Advanced Hepatocellular Carcinoma

“…More specifically, IFN induces p53, which enhances apoptosis by FU, and influences the cell cycle via p27 Kip1 or apoptosis via Bcl-xL [22,23]. From a clinical perspective, Takaki-Hamade et al [24] and Eun et al [25] concluded that combined IFN treatment did not have an incremental effect. Thus, the benefit of adding IFN to HAIC with FU has not been proven clinically.…”

Neutrophil/lymphocyte ratio as a prognostic indicator of hepatic arterial infusion chemotherapy with arterial cisplatin plus continuous 5‐fluorouracil

“…cisplatin, 5-fluorouracil , epirubicin, mitomycin-C and interferon) are administrated individually or in combination for advanced HCC. Especially, administration of 5-FU with cisplatin (FP) has been commonly used for advanced HCC [9][10][11][12][13][14][15][16][17] because of their synergistic effects. 11,18,19 However, there is no consensus regarding the most useful method to administrate FP by HAIC.…”