Hepatic Artery Occlusion Following Hepatic Artery Catheterization

Prevention of Hepatic Artery Occlusion During Continuous Infusion of Fluorouracil Using Liposteroid

“…Lucus et al [3] reported a rate of occurrence of 10.1% for arterial infusions of fluorouracil or 5-fluoro-2-deoxyuridine, and Oberfield et al [4] reported a high overall incidence of 39.6%, consisting of a partial occlusion rate of 20.8% and a complete occlusion rate of 18.8%. Because use of 5-fluoro-2-deoxyuridine is not permitted by the health insurance system in Japan, fluorouracil has been used to treat hepatic arterial infusions caused by liver metastasis from colorectal cancer.…”

“…Hepatic arterial infusion chemotherapy often causes the occlusion of the hepatic artery; rates of occurrence of 10-40% have been reported [2][3][4]. No effective method of preventing this complication has been established, and the complication makes it impossible to continue the infusion therapy.…”

A Case of Multiple Thrombo-Emboli with a Non-Functioning Kidney revealed during a Brain Scanning Procedure and with an Intra-Hepatic Artery Occlusion

“…In contrast occlusion is quite com-toms. mon after hepatic artery catheterisation for cytoxic infusion as reported by Lucas, Tumacder and Wilson (1971). They found eighteen cases of complete or partial hepatic artery thrombosis in 119 patients.…”

A new animal model of continuous catheterization for investigating mechanisms of arteritis associated with chemotherapy

“…Arterial infusion chemotherapy causes narrowing and occlusion of the arteries that are infused with anti-cancer drugs (Lucas et al, 1971). We established an animal model with which to elucidate the mechanisms of vascular damage induced by anti-cancer agents administered via continuous catheterization.…”