Hepatic biotransformation and antioxidant enzyme activities in Mediterranean fish from different habitat depths

Ribalta, Carla; Sánchez-Hernández, Juan C.; Solé, Montserrat

doi:10.1016/j.scitotenv.2015.06.001

Cited by 48 publications

(28 citation statements)

References 51 publications

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“…By contrast, CbE (pNPA) activity in fish was inhibited in the 2015 sampling. Recent in vivo and in vitro studies with PPCPs have indicated that CbE activity can be modulated by a broad range of chemicals as it participates in its metabolism and detoxification reactions and can also be inhibited in vitro by lipid regulators as it occurs in humans (Ribalta et al 2015;Solé et al 2014;Solé and Sanchez-Hernandez 2015). Many of these chemicals are found in the watercourse of the Ebre river (Lopez-Serna et al 2012;Osorio et al 2016).…”

Section: Discussionmentioning

confidence: 99%

The use of juvenile Solea solea as sentinel in the marine platform of the Ebre Delta: in vitro interaction of emerging contaminants with the liver detoxification system

Crespo

Solé

2016

Environ Sci Pollut Res

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Juveniles of Solea solea were sampled during the spring season in three consecutive years at a marine site by the mouth of the Ebre river. The aim was to assess if the extractive works from the toxic load upstream the river could be reflected on the health status of the fish living at the immediate sea. The biomarkers selected for the in vivo field study are commonly used as indicators of chemical exposures. They include activities of energy metabolism: lactate dehydrogenase (LDH) and citrate synthase (CS); neurotoxicity: cholinesterases (ChE); xenobiotic metabolism: cytochrome P450 (CYP)-dependent: EROD and BFCOD, carboxylesterase (CbE), glutathione S-transferase (GST) and uridine diphosphate glucuronyltransferase (UDPGT); and oxidative stress parameters such as catalase (CAT), glutathione reductase (GR) and glutathione peroxidase (GPX) as well as levels of lipid peroxidation (LPO). These biomarkers were mostly analysed in liver but also in gills and muscle depending on their particular tissue distribution and role. A complementary in vitro approach was also sought to see the capacity of common emerging contaminants (pharmaceuticals and personal care products; PPCPs) to interact with the liver microsomal detoxification system of the fish (EROD, BFCOD and CbE activities). The results indicated that in fish sampled in 2015 there was an enhancement in detoxification parameters (EROD, BFCOD and gill GR), muscular ChEs and gill CS, but a decrease in CbE activity and a marked oxidative stress situation (increased LPO and decreased CAT activity). Also, 4 out of the 10 PPCPs tested in vitro were able to interact with the CYP3A4 (BFCOD) enzymatic system while the lipid regulators simvastatin and fenofibrate inhibited CbE activity, as it occurs in higher vertebrates. The in vivo results support the use of a multibiomarker approach when assessing the disturbances due to chemical exposures, not only spatially but also over time, once the influence of other variables has been taken into consideration. The in vitro results highlight the importance of the CYP3A4 and CbE pathway in pharmaceutical metabolism, also in fish.

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Section: Discussionmentioning

confidence: 99%

The use of juvenile Solea solea as sentinel in the marine platform of the Ebre Delta: in vitro interaction of emerging contaminants with the liver detoxification system

Crespo

Solé

2016

Environ Sci Pollut Res

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“…The selection of BNPP and eserine was made given they are specific CE and esterase inhibitors, respectively. The choice of PPCPs and plastic additives (Table 2) was based on: i) their already reported capacity to interfere with specific mammalian CEs (references within Table 2) ii) their described CE modulation in marine species (Ribalta et al, 2015;Solé and Sanchez-Hernandez, 2015; and; iii) their environmental occurrence and bioaccumulation potential (log Kow > 3).…”

Section: J O U R N a L P R E -P R O O Fmentioning

confidence: 99%

“…Recent studies on marine bivalves have demonstrated the in vivo ability of CEs to metabolise drugs such as the retroviral Tamiflu  (Dallares et al, 2019) and to respond to the presence of pesticides in the environment (Dallares et al, 2018). The CEs in vitro sensitivity to pesticides, pharmaceutical drugs and plastic additives has also been reported in a large number of aquatic species (Nos et al, 2020;Ribalta et al, 2015;Sole and Sanchez-Hernandez, 2015;Sole and Sanchez-Hernandez, 2018). Gastropods CEs have also been revealed to be sensitive to pesticides but studies are largely based on freshwater species (Bianco et al, 2014;Laguerre et al, 2009;Otero and Kristoff, 2016).…”

Section: Introductionmentioning

confidence: 97%

The use of an in vitro approach to assess marine invertebrate carboxylesterase responses to chemicals of environmental concern

Solé

Freitas

Rivera‐Ingraham

2021

Environmental Toxicology and Pharmacology

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“…quinone reductase and epoxide hydrolase (Chen, 2012). In addition, biotransformation of xenobiotics may increase the production of reactive oxygen species (ROS), which are neutralized by antioxidant enzymes such as catalase, glutathione peroxidase, glutathione reductase and superoxide dismutase (Ribalta et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Light- and clock-control of genes involved in detoxification

Carmona‐Antoñanzas

Santi

Migaud

et al. 2017

Chronobiology International

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25Circadian regulation of hepatic detoxification seems to be amongst the key roles of the 26 biological clock. The liver is the major site for biotransformation, and in mammals, it 27 contains several clock-controlled transcription factors such as PAR basic leucine zipper 28 proteins (bZIP) and basic-helix-loop-helix (bHLH)-PAS family that act as circadian 29 regulators of detoxification genes. This investigation explored the existence of daily and 30 circadian expression of transcription factors involved in detoxification, as well as the 31 temporal profile of a set of their target genes in zebrafish liver. In our study, zebrafish were 32 able to synchronize to a light-dark (LD) cycle and displayed a diurnal pattern of activity. In 33 addition, the expression of clock genes presented daily and circadian rhythmicity in liver. 34Apart from hlfa, the expression of PAR bZIP transcription factors also displayed daily 53showed that time of day should be considered when designing toxicological studies or 54 administering drugs to fish.

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Hepatic biotransformation and antioxidant enzyme activities in Mediterranean fish from different habitat depths

Cited by 48 publications

References 51 publications

The use of juvenile Solea solea as sentinel in the marine platform of the Ebre Delta: in vitro interaction of emerging contaminants with the liver detoxification system

The use of juvenile Solea solea as sentinel in the marine platform of the Ebre Delta: in vitro interaction of emerging contaminants with the liver detoxification system

The use of an in vitro approach to assess marine invertebrate carboxylesterase responses to chemicals of environmental concern

Light- and clock-control of genes involved in detoxification

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